SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 GLN A 306
HIS A 304
PRO A 400
 None
 0.84A 1d8cA-5mz8A:
undetectable		 1d8cA-5mz8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		4 / 8 SER A 108
THR A 199
LEU A 176
GLU A 474
 None
None
SIN  A 501 (-4.8A)
None
 0.92A 1mxgA-5mz8A:
undetectable		 1mxgA-5mz8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 ASP A 468
TYR A 422
LYS A 394
 EDO  A 510 (-3.8A)
None
None
 0.93A 2othA-5mz8A:
undetectable		 2othA-5mz8A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		4 / 6 ASP A 459
HIS A 179
TYR A 463
ASN A 171
 None
None
SIN  A 501 (-4.7A)
SIN  A 501 (-3.4A)
 1.19A 2zs9A-5mz8A:
undetectable		 2zs9A-5mz8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		4 / 5 ILE A 397
HIS A 304
ARG A 307
GLY A 270
 None
None
PEG  A 512 ( 4.8A)
PEG  A 512 (-3.5A)
 1.27A 3b9mA-5mz8A:
undetectable		 3b9mA-5mz8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 12 ALA A 178
LEU A 174
LEU A  93
VAL A  89
ILE A 205
 None
 1.10A 3fl9G-5mz8A:
undetectable		 3fl9G-5mz8A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 MET A 166
CYH A 189
PRO A 183
 None
 1.32A 3h52C-5mz8A:
undetectable		 3h52C-5mz8A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 12 GLY A 370
ASN A 372
GLY A 371
ILE A 291
LEU A 329
 None
 1.04A 3ihtA-5mz8A:
3.8		 3ihtA-5mz8A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 12 TYR A 405
GLY A 365
ALA A 360
ILE A 397
MET A 305
 None
 1.30A 3ld6A-5mz8A:
undetectable		 3ld6A-5mz8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 12 TYR A 405
GLY A 365
ALA A 360
ILE A 397
MET A 305
 None
 1.18A 3ld6B-5mz8A:
undetectable		 3ld6B-5mz8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 11 LEU A  86
ILE A 185
ALA A 178
ALA A 479
ALA A 184
 None
 1.08A 3mdtB-5mz8A:
undetectable		 3mdtB-5mz8A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 11 LEU A  86
PHE A 126
ILE A 185
ALA A 479
ALA A 184
 None
 0.96A 3mdtB-5mz8A:
undetectable		 3mdtB-5mz8A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 12 LEU A 403
LEU A 341
GLY A 371
ILE A 353
ALA A 350
 None
 1.05A 3uwlD-5mz8A:
undetectable		 3uwlD-5mz8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 12 ASN A 292
GLY A 298
GLY A 299
ASN A 171
GLY A 109
 None
None
None
SIN  A 501 (-3.4A)
None
 1.01A 4obwB-5mz8A:
3.5		 4obwB-5mz8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 GLY A 342
PRO A 343
GLN A 300
 None
 0.30A 4oltB-5mz8A:
undetectable		 4oltB-5mz8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		5 / 12 ILE A 123
THR A 122
ALA A 182
LEU A  93
LEU A 206
 None
 1.34A 4pbhA-5mz8A:
undetectable		 4pbhA-5mz8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 GLY A 342
PRO A 343
GLN A 300
 None
 0.23A 4qwpB-5mz8A:
undetectable		 4qwpB-5mz8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		4 / 6 TYR A 296
TYR A 340
GLY A 117
ASP A 124
 SIN  A 501 (-4.7A)
None
None
None
 1.10A 5emlA-5mz8A:
3.2		 5emlA-5mz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 VAL A 181
SER A 168
MET A 266
 None
 0.75A 5ikqA-5mz8A:
undetectable		 5ikqA-5mz8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 THR A 122
ALA A 178
LYS A 180
 None
 0.76A 6fgcA-5mz8A:
undetectable		 6fgcA-5mz8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		3 / 3 THR A 122
ALA A 178
LYS A 180
 None
 0.75A 6fgdA-5mz8A:
2.8		 6fgdA-5mz8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5mz8 ALDEHYDE
DEHYDROGENASE 21
(Physcomitrella
patens) 		4 / 7 ALA A 220
GLY A 219
LEU A 218
GLY A 207
 None
 0.76A 6nm4A-5mz8A:
undetectable		 6nm4A-5mz8A:
16.87