SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		3 / 3 VAL A 813
TRP A 821
TRP A1009
 None
 1.43A 1c4dA-5mzaA:
undetectable
1c4dB-5mzaA:
undetectable		 1c4dA-5mzaA:
6.76
1c4dB-5mzaA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		4 / 6 TRP A1062
THR A1004
LEU A1000
TYR A1165
 None
 1.23A 1gtiC-5mzaA:
undetectable		 1gtiC-5mzaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		4 / 5 ASP A1096
LEU A1072
ALA A 830
LEU A 918
 None
 1.08A 1nh8A-5mzaA:
undetectable		 1nh8A-5mzaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		3 / 3 ASP A 937
PHE A 870
ASN A 930
 None
 0.73A 1sg9B-5mzaA:
undetectable		 1sg9B-5mzaA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 12 ALA A 878
ALA A 877
LEU A 876
ALA A 974
ILE A 935
 None
 1.01A 2aclA-5mzaA:
2.4
2aclE-5mzaA:
undetectable		 2aclA-5mzaA:
18.55
2aclE-5mzaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 11 ALA A 878
ALA A 877
LEU A 876
ALA A 974
ILE A 935
 None
 0.96A 2aclE-5mzaA:
undetectable		 2aclE-5mzaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 12 ILE A 913
LEU A 932
ASN A 930
VAL A 874
GLU A 848
 None
 1.20A 2vn0A-5mzaA:
undetectable		 2vn0A-5mzaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gB-5mzaA:
undetectable		 3j6gB-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gD-5mzaA:
undetectable		 3j6gD-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gF-5mzaA:
undetectable		 3j6gF-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gH-5mzaA:
undetectable		 3j6gH-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gJ-5mzaA:
undetectable		 3j6gJ-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gL-5mzaA:
undetectable		 3j6gL-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gN-5mzaA:
undetectable		 3j6gN-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gP-5mzaA:
undetectable		 3j6gP-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 10 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gR-5mzaA:
undetectable		 3j6gR-5mzaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 12 LEU A 850
PHE A 936
LEU A 932
GLY A 872
LEU A 871
 None
 0.96A 3tbgB-5mzaA:
undetectable		 3tbgB-5mzaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		3 / 3 TYR A1104
GLY A1084
PRO A1085
 None
 0.63A 4qwpA-5mzaA:
undetectable		 4qwpA-5mzaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		4 / 6 TYR A 880
ASN A 846
LEU A 875
PHE A 783
 3PO  A1301 (-3.8A)
None
None
None
 1.16A 4twdI-5mzaA:
undetectable
4twdJ-5mzaA:
undetectable		 4twdI-5mzaA:
18.67
4twdJ-5mzaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		4 / 6 ASN A 811
THR A 819
PRO A 820
VAL A 813
 None
 0.99A 4yoaA-5mzaA:
undetectable		 4yoaA-5mzaA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		4 / 7 TYR A 951
PHE A 936
ILE A 939
LEU A 756
 None
 1.03A 5esmA-5mzaA:
undetectable		 5esmA-5mzaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		5 / 12 ALA A 878
ALA A 877
LEU A 876
ALA A 974
ILE A 935
 None
 0.92A 6a60D-5mzaA:
undetectable		 6a60D-5mzaA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		4 / 6 TYR A1051
TYR A1010
GLU A1013
GLN A1014
 None
 1.28A 6d8pA-5mzaA:
1.6		 6d8pA-5mzaA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		4 / 6 LEU A 932
ASP A 922
GLN A 822
GLU A 925
 None
 1.26A 6djzC-5mzaA:
undetectable		 6djzC-5mzaA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)
(Plasmodium
falciparum) 		3 / 3 TRP A 972
ILE A 902
GLU A 896
 None
 0.67A 6hcxA-5mzaA:
undetectable		 6hcxA-5mzaA:
11.86