SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A  68
LEU A  34
ARG A  11
ILE A  57
LEU A  47
 None
 1.16A 1g50B-5mzhA:
undetectable		 1g50B-5mzhA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		5 / 11 LEU A  68
LEU A  34
ARG A  11
ILE A  57
LEU A  47
 None
 1.15A 1g50C-5mzhA:
undetectable		 1g50C-5mzhA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 7 VAL A 266
SER A 267
ASP A 310
LYS A 352
 None
 0.97A 1hwiC-5mzhA:
undetectable		 1hwiC-5mzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 7 VAL A 266
SER A 267
ASP A 310
LYS A 352
 None
 0.97A 1hwiD-5mzhA:
undetectable		 1hwiD-5mzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 7 THR A 334
LEU A 289
VAL A 279
ASP A 314
 None
 1.03A 1t87A-5mzhA:
undetectable		 1t87A-5mzhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		5 / 9 ILE A 415
ILE A 405
THR A 111
ALA A  92
LEU A  90
 None
 1.13A 2m9qA-5mzhA:
undetectable		 2m9qA-5mzhA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		3 / 3 GLU A  44
GLN A  49
ARG A  52
 SO4  A 501 (-4.5A)
None
None
 0.95A 2w3bB-5mzhA:
undetectable		 2w3bB-5mzhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 4 GLY A 228
VAL A 237
GLY A 275
THR A 276
 None
 0.83A 3ib2A-5mzhA:
undetectable		 3ib2A-5mzhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 8 GLY A 112
PHE A  87
PHE A 109
PHE A 102
 None
 0.96A 3ko0D-5mzhA:
undetectable
3ko0E-5mzhA:
undetectable		 3ko0D-5mzhA:
12.61
3ko0E-5mzhA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 8 PHE A 109
PHE A 102
GLY A 112
PHE A  87
 None
 1.02A 3ko0B-5mzhA:
undetectable
3ko0J-5mzhA:
undetectable		 3ko0B-5mzhA:
12.61
3ko0J-5mzhA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 7 PHE A 109
PHE A 102
GLY A 112
PHE A  87
 None
 1.01A 3ko0K-5mzhA:
undetectable
3ko0S-5mzhA:
undetectable		 3ko0K-5mzhA:
12.61
3ko0S-5mzhA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 7 PHE A 109
PHE A 102
GLY A 112
PHE A  87
 None
 0.97A 3ko0R-5mzhA:
undetectable
3ko0T-5mzhA:
undetectable		 3ko0R-5mzhA:
12.61
3ko0T-5mzhA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 5 SER A 367
ASP A 306
ASP A 284
ILE A 283
 None
 1.37A 3uj7B-5mzhA:
undetectable		 3uj7B-5mzhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		3 / 3 SER A 322
TYR A 332
ASP A 326
 None
 0.82A 4rp8C-5mzhA:
undetectable		 4rp8C-5mzhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A  17
LEU A  19
LYS A  30
ILE A  32
ILE A  50
 None
 1.02A 4y0rA-5mzhA:
undetectable		 4y0rA-5mzhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 5 THR A 202
GLY A 197
GLU A 181
ASP A 200
 None
 1.26A 5c0oH-5mzhA:
undetectable		 5c0oH-5mzhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 6 GLY A 401
GLU A 400
PHE A 397
ILE A 405
 None
 0.94A 5kmfA-5mzhA:
undetectable
5kmfC-5mzhA:
undetectable		 5kmfA-5mzhA:
19.25
5kmfC-5mzhA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Chlamydomonas
reinhardtii) 		4 / 6 GLY A 401
GLU A 400
PHE A 397
ILE A 415
 None
 0.90A 5kmfA-5mzhA:
undetectable
5kmfC-5mzhA:
undetectable		 5kmfA-5mzhA:
19.25
5kmfC-5mzhA:
19.25