SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 6 ASP A1305
LEU A1306
VAL A1307
ILE A1310
 None
GOL  A2045 (-3.9A)
EDO  A2022 (-4.1A)
None
 0.75A 1s9qA-5mznA:
undetectable		 1s9qA-5mznA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1169
LEU A1625
SER A1626
LEU A1163
 None
None
EDO  A2011 ( 4.5A)
None
 1.09A 1ya3A-5mznA:
undetectable		 1ya3A-5mznA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 SER A1567
VAL A1587
LEU A1407
 None
 0.72A 1yajG-5mznA:
undetectable		 1yajG-5mznA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A1702
ALA A1856
ILE A1726
GLU A1721
ILE A1722
 EDO  A2029 (-3.2A)
None
EDO  A2009 ( 3.9A)
EDO  A2029 (-2.7A)
None
 1.38A 2dm6A-5mznA:
3.3
2dm6B-5mznA:
3.2		 2dm6A-5mznA:
17.88
2dm6B-5mznA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1606
GLY A1608
PHE A1584
 None
 0.69A 2m2pB-5mznA:
undetectable		 2m2pB-5mznA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A1746
MET A1759
MET A1756
LEU A1620
VAL A1816
 None
 0.88A 2n27A-5mznA:
undetectable		 2n27A-5mznA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1818
THR A1819
PHE A1669
ASP A1842
 None
 1.14A 2wm3A-5mznA:
2.7		 2wm3A-5mznA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 8 GLN A1207
LEU A1250
LYS A1251
ASN A1252
 None
 1.00A 2xn3A-5mznA:
undetectable
2xn3B-5mznA:
undetectable		 2xn3A-5mznA:
19.79
2xn3B-5mznA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1427
LEU A1368
GLY A1369
ILE A1343
PHE A1374
 None
EDO  A2014 (-4.2A)
None
None
GOL  A2046 ( 4.2A)
 1.02A 3bjwF-5mznA:
undetectable		 3bjwF-5mznA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1701
PHE A1875
SER A1704
 None
None
EDO  A2029 (-2.2A)
 0.68A 3i5uB-5mznA:
undetectable		 3i5uB-5mznA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1841
ASP A1849
ASP A1842
 None
GOL  A2049 ( 4.6A)
None
 0.62A 3jayA-5mznA:
undetectable		 3jayA-5mznA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1841
ASP A1849
ASP A1842
 None
GOL  A2049 ( 4.6A)
None
 0.72A 3jb2A-5mznA:
3.3		 3jb2A-5mznA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1841
ASP A1849
ASP A1842
 None
GOL  A2049 ( 4.6A)
None
 0.79A 3jb3A-5mznA:
undetectable		 3jb3A-5mznA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 8 ARG A1464
HIS A1557
VAL A1561
GLN A1438
 None
PEG  A2061 ( 4.8A)
PEG  A2062 ( 4.9A)
None
 1.18A 3uy4A-5mznA:
undetectable		 3uy4A-5mznA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A1183
ILE A1211
VAL A1260
VAL A1197
 None
 0.80A 4jltA-5mznA:
undetectable		 4jltA-5mznA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1811
LEU A1818
GLY A1615
ASP A1616
THR A1819
 EDO  A2010 ( 2.9A)
None
None
None
None
 1.28A 4mubA-5mznA:
undetectable		 4mubA-5mznA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1602
SER A1570
GLY A1571
ALA A1573
THR A1297
 None
EDO  A2003 ( 4.1A)
EDO  A2003 (-3.3A)
None
None
 1.30A 4xt8A-5mznA:
undetectable		 4xt8A-5mznA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 12 SER A1570
GLY A1571
ALA A1573
GLU A1292
THR A1297
 EDO  A2003 ( 4.1A)
EDO  A2003 (-3.3A)
None
None
None
 1.29A 4xt8A-5mznA:
undetectable		 4xt8A-5mznA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1584
GLY A1581
TYR A1606
ALA A1578
 None
 1.03A 4yshB-5mznA:
undetectable		 4yshB-5mznA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A1352
GLY A1607
LEU A1598
LEU A1638
THR A1297
 None
 1.09A 4zmeA-5mznA:
undetectable		 4zmeA-5mznA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 12 GLN A1619
GLY A1357
ARG A1656
MET A1657
ILE A1825
 PEG  A2057 ( 2.9A)
None
PEG  A2057 ( 3.5A)
None
None
 1.27A 5fesA-5mznA:
undetectable		 5fesA-5mznA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 THR A1819
PRO A1359
ASP A1616
 None
PEG  A2057 ( 3.5A)
None
 0.85A 5l8dB-5mznA:
undetectable		 5l8dB-5mznA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		3 / 3 THR A1819
PRO A1359
ASP A1616
 None
PEG  A2057 ( 3.5A)
None
 0.85A 5mwuB-5mznA:
undetectable		 5mwuB-5mznA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 8 SER A1600
ILE A1601
LEU A1638
MET A1642
 None
 0.82A 5u4sB-5mznA:
2.1		 5u4sB-5mznA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 9 GLY A1426
LEU A1423
ILE A1371
GLY A1372
LEU A1375
 EDO  A2019 ( 3.4A)
EDO  A2019 (-4.4A)
None
None
None
 0.92A 5vkqC-5mznA:
undetectable
5vkqD-5mznA:
undetectable		 5vkqC-5mznA:
18.13
5vkqD-5mznA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A1654
ASP A1616
ASN A1336
TYR A1670
 None
None
ADP  A2001 (-4.0A)
None
 1.35A 6iftA-5mznA:
2.0		 6iftA-5mznA:
17.71