SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.91A 1fbyA-5mzyA:
undetectable		 1fbyA-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.89A 1fbyB-5mzyA:
undetectable		 1fbyB-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.92A 1fm6A-5mzyA:
undetectable		 1fm6A-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 1.00A 1fm6U-5mzyA:
undetectable		 1fm6U-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 1k74A-5mzyA:
undetectable		 1k74A-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 1.00A 1xiuA-5mzyA:
undetectable		 1xiuA-5mzyA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 1.01A 2aclA-5mzyA:
undetectable
2aclE-5mzyA:
undetectable		 2aclA-5mzyA:
24.01
2aclE-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 10 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.94A 3falC-5mzyA:
undetectable		 3falC-5mzyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 11 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.95A 3fc6A-5mzyA:
undetectable		 3fc6A-5mzyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 3fc6C-5mzyA:
undetectable		 3fc6C-5mzyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		3 / 3 ILE A  16
VAL A 161
ARG A 192
 None
 0.77A 3p73A-5mzyA:
undetectable		 3p73A-5mzyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		4 / 6 LEU A  50
LEU A  22
LEU A 164
PRO A  33
 None
 0.84A 3q1eA-5mzyA:
undetectable
3q1eC-5mzyA:
undetectable		 3q1eA-5mzyA:
16.23
3q1eC-5mzyA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		4 / 6 LEU A 164
PRO A  33
LEU A  50
LEU A  22
 None
 0.82A 3q1eA-5mzyA:
undetectable
3q1eC-5mzyA:
undetectable		 3q1eA-5mzyA:
16.23
3q1eC-5mzyA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 GLY A 173
ALA A 169
ALA A 195
VAL A 197
ASP A 215
 None
 1.45A 4df3B-5mzyA:
undetectable		 4df3B-5mzyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		3 / 3 LEU A 163
ILE A 194
ARG A 192
 None
 0.71A 4mk4B-5mzyA:
undetectable		 4mk4B-5mzyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 VAL A 186
ALA A 116
PRO A 180
ALA A 189
GLY A 188
 None
 1.33A 5tzoC-5mzyA:
undetectable		 5tzoC-5mzyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.92A 5z12B-5mzyA:
undetectable		 5z12B-5mzyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.97A 5z12C-5mzyA:
undetectable		 5z12C-5mzyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 6a5yD-5mzyA:
undetectable		 6a5yD-5mzyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		5 / 12 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.91A 6a5zL-5mzyA:
undetectable		 6a5zL-5mzyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		4 / 5 GLU A 137
HIS A 104
LEU A 113
VAL A 109
 None
 1.16A 6bc9A-5mzyA:
undetectable		 6bc9A-5mzyA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		4 / 5 LEU A  53
THR A 182
THR A  24
GLY A  26
 None
 1.18A 6gtqA-5mzyA:
undetectable		 6gtqA-5mzyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A
(Myxococcus
xanthus) 		4 / 5 LEU A   9
ILE A  51
MET A  34
GLY A 223
 None
 0.91A 6hd6A-5mzyA:
undetectable		 6hd6A-5mzyA:
13.52