SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 7 VAL A  82
LYS A  84
GLU A 103
PRO A 102
 None
 1.07A 3hs4A-5n0lA:
undetectable		 3hs4A-5n0lA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 8 ASN A  91
THR A 113
LEU A 129
SER A  39
 None
 1.13A 3kp2A-5n0lA:
undetectable
3kp2B-5n0lA:
undetectable		 3kp2A-5n0lA:
undetectable
3kp2B-5n0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 7 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.00A 4a97E-5n0lA:
undetectable		 4a97E-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 8 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.01A 4a97C-5n0lA:
undetectable		 4a97C-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 8 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.02A 4a97D-5n0lA:
undetectable		 4a97D-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 8 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.02A 4a97G-5n0lA:
undetectable		 4a97G-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 7 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.04A 4a97H-5n0lA:
undetectable		 4a97H-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		4 / 8 PHE A  74
TYR A  78
VAL A  82
ILE A  85
 ILE  A 201 ( 4.7A)
None
None
None
 1.04A 4a97I-5n0lA:
undetectable		 4a97I-5n0lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		3 / 3 ARG A 107
TYR A  78
GLU A 104
 ILE  A 201 (-4.0A)
None
ILE  A 201 (-2.8A)
 0.71A 4zzbE-5n0lA:
undetectable		 4zzbE-5n0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		3 / 3 GLY A 106
LEU A 108
HIS A 105
 None
 0.67A 5u63A-5n0lA:
undetectable		 5u63A-5n0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Clostridioides
difficile) 		3 / 3 GLY A 106
LEU A 108
HIS A 105
 None
 0.63A 5u63B-5n0lA:
undetectable		 5u63B-5n0lA:
undetectable