SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DYR_A_TOPA407_1 (DIHYDROFOLATE REDUCTASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 11	ILE B 160 ALA B 137 ILE B 85 ILE B 156 THR B 134	None	1.07A	1dyrA-5n1qB: undetectable	1dyrA-5n1qB: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	HIS B 199 TYR B 200 LEU B 178 ASP B 169 GLY B 180	None	0.93A	1etrH-5n1qB: undetectable	1etrH-5n1qB: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BLA_A_CP6A302_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 11	ILE B 78 ALA B 82 ASN B 49 ILE B 175 ILE B 53	None	1.28A	2blaA-5n1qB: undetectable	2blaA-5n1qB: 20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CD2_A_FOLA307_0 (DIHYDROFOLATE REDUCTASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	ILE B 160 ALA B 137 ILE B 85 ILE B 156 THR B 134	None	1.00A	2cd2A-5n1qB: undetectable	2cd2A-5n1qB: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	TYR B 334 LEU B 310 ILE B 315 VAL B 316 VAL B 267	None	1.27A	2g72B-5n1qB: undetectable	2g72B-5n1qB: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_B_STIB600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 6	LEU B 93 VAL B 48 ILE B 85 MET B 131	None	1.07A	2hyyB-5n1qB: undetectable	2hyyB-5n1qB: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_B_STIB600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 6	VAL B 79 VAL B 48 ILE B 142 MET B 131	None	1.25A	2hyyB-5n1qB: undetectable	2hyyB-5n1qB: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QXS_A_RALA600_1 (ESTROGEN RECEPTOR)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	ALA B 308 LEU B 310 LEU B 239 ILE B 27 PRO B 392	None	1.07A	2qxsA-5n1qB: undetectable	2qxsA-5n1qB: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QXS_B_RALB600_1 (ESTROGEN RECEPTOR)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	ALA B 308 LEU B 310 LEU B 239 ILE B 27 PRO B 392	None	1.05A	2qxsB-5n1qB: undetectable	2qxsB-5n1qB: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A27_A_SAMA250_1 (UNCHARACTERIZED PROTEIN MJ1557)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	3 / 3	MET C 62 GLU B 409 ASN B 198	None	1.08A	3a27A-5n1qC: undetectable	3a27A-5n1qC: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADS_A_IMNA2_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 6	ILE B 42 ILE B 175 TYR B 170 LEU B 192	None	1.02A	3adsA-5n1qB: undetectable	3adsA-5n1qB: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APV_A_TP0A190_1 (ALPHA-1-ACID GLYCOPROTEIN 2)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	TYR B 127 PHE B 425 PHE B 214 SER B 177 TYR B 419	None	1.50A	3apvA-5n1qB: undetectable	3apvA-5n1qB: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DTU_C_DXCC576_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 8	PRO B 392 ALA B 396 ALA B 399 THR B 330	None	0.83A	3dtuC-5n1qB: undetectable 3dtuD-5n1qB: undetectable	3dtuC-5n1qB: 20.61 3dtuD-5n1qB: 20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZJ_A_ACRA405_1 (ACARBOSE/MALTOSE BINDING PROTEIN GACH)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY B 240 GLU B 219 ALA B 222 ASP B 348 GLY B 377	None	1.16A	3jzjA-5n1qB: undetectable	3jzjA-5n1qB: 24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K5V_A_STIA2_2 (TYROSINE-PROTEIN KINASE ABL1)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 6	VAL B 79 VAL B 48 ILE B 142 MET B 131	None	1.21A	3k5vA-5n1qB: undetectable	3k5vA-5n1qB: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_B_30BB500_1 (GENOME POLYPROTEIN)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	5 / 12	HIS B 364 ASP C 116 VAL B 381 GLY B 370 ALA B 328	None	1.09A	3keeB-5n1qB: undetectable	3keeB-5n1qB: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NU3_B_478B401_2 (PROTEASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 11	GLY B 354 ALA B 356 VAL B 327 PRO B 392 ILE B 331	None	0.90A	3nu3B-5n1qB: undetectable	3nu3B-5n1qB: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXV_D_MTXD2000_2 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	3 / 3	LEU C 31 ARG C 151 ASN C 17	None	0.77A	3qxvD-5n1qC: undetectable	3qxvD-5n1qC: 17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3N_A_DLUA398_1 (PFV INTEGRASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	4 / 8	ASP C 204 GLY C 206 TYR C 190 PRO C 202	None	1.00A	3s3nA-5n1qC: undetectable	3s3nA-5n1qC: 21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_E_9PLE1_1 (CYTOCHROME P450 2A13)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	4 / 8	PHE C 147 ALA C 97 PHE C 90 ALA C 91	None	0.98A	3t3sE-5n1qC: undetectable	3t3sE-5n1qC: 18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKG_C_ROCC901_2 (PROTEASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU B 246 GLY B 435 ALA B 436 ILE B 443 ILE B 27	None	0.97A	3tkgD-5n1qB: undetectable	3tkgD-5n1qB: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_A_ADNA401_2 (ADENOSINE KINASE, PUTATIVE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	4 / 5	LEU B 332 ALA B 328 MET C 109 ASN B 317	None	1.35A	3uq6A-5n1qB: undetectable	3uq6A-5n1qB: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	HIS B 199 TYR B 200 LEU B 178 ASP B 169 GLY B 180	None	1.08A	4hfpB-5n1qB: undetectable	4hfpB-5n1qB: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L39_B_SALB601_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 7	THR B 45 ILE B 422 THR B 203 GLY B 416	None	0.95A	4l39B-5n1qB: undetectable	4l39B-5n1qB: 19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PEV_B_ADNB501_1 (MEMBRANE LIPOPROTEIN FAMILY PROTEIN)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	5 / 12	VAL C 238 SER B 289 PHE B 291 GLY B 343 GLY C 10	None	1.22A	4pevB-5n1qC: undetectable	4pevB-5n1qC: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q5M_A_ROCA1101_1 (PROTEASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY B 346 ILE B 331 VAL B 267 ARG C 245 THR B 355	None	1.04A	4q5mA-5n1qB: undetectable	4q5mA-5n1qB: 19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QN9_B_DXCB610_0 (N-ACYL-PHOSPHATIDYLE THANOLAMINE-HYDROLYZ ING PHOSPHOLIPASE D)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	3 / 3	GLY B 371 PRO B 372 ALA B 328	None	0.56A	4qn9B-5n1qB: undetectable	4qn9B-5n1qB: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	ILE B 315 VAL B 314 PHE B 375 CYH B 398	None	1.34A	4rzvA-5n1qB: undetectable	4rzvA-5n1qB: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQG_A_AG2A505_1 (HOMOSPERMIDINE SYNTHASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 8	ARG B 426 ASP B 423 PHE B 425 VAL B 418	None	1.16A	4xqgA-5n1qB: undetectable	4xqgA-5n1qB: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EB5_A_010A609_0 (HNL ISOENZYME 5)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 11	ALA B 141 ALA B 137 LEU B 138 LEU B 50 VAL B 114	None	1.22A	5eb5A-5n1qB: undetectable	5eb5A-5n1qB: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EUM_B_ACTB603_0 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 4	ALA B 320 ASN B 317 ARG C 113 ILE C 76	None	1.41A	5eumB-5n1qB: 0.6	5eumB-5n1qB: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_A_ADNA501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.20A	5hm8A-5n1qB: undetectable	5hm8A-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_B_ADNB501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.21A	5hm8B-5n1qB: undetectable	5hm8B-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_C_ADNC501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.21A	5hm8C-5n1qB: undetectable	5hm8C-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_D_ADND501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.20A	5hm8D-5n1qB: undetectable	5hm8D-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_E_ADNE501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.21A	5hm8E-5n1qB: undetectable	5hm8E-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_F_ADNF501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.21A	5hm8F-5n1qB: undetectable	5hm8F-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_G_ADNG501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.10A	5hm8G-5n1qB: undetectable	5hm8G-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HM8_H_ADNH501_2 (ADENOSYLHOMOCYSTEINA SE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 5	GLU B 225 THR B 221 GLU B 219 LEU B 178	None	1.21A	5hm8H-5n1qB: undetectable	5hm8H-5n1qB: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVN_C_PFLC407_1 (PROTON-GATED ION CHANNEL)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	5 / 9	TYR B 333 TYR C 102 TYR C 108 THR C 117 ILE C 126	None	1.43A	5mvnC-5n1qB: 1.0	5mvnC-5n1qB: 10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVN_D_PFLD410_1 (PROTON-GATED ION CHANNEL)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	5 / 10	TYR B 333 TYR C 102 TYR C 108 THR C 117 ILE C 126	None	1.43A	5mvnD-5n1qB: undetectable	5mvnD-5n1qB: 10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODC_G_ACTG703_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	4 / 4	GLU C 134 ARG C 46 ARG C 84 GLU C 130	None	1.24A	5odcB-5n1qC: 0.0 5odcC-5n1qC: 0.0 5odcG-5n1qC: 0.0	5odcB-5n1qC: 24.31 5odcC-5n1qC: 19.48 5odcG-5n1qC: 16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5PHH_A_LDPA414_1 (LYSINE-SPECIFIC DEMETHYLASE 4D)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus)	4 / 6	ARG C 19 ALA C 11 LEU C 234 TYR C 221	None	1.12A	5phhA-5n1qC: undetectable	5phhA-5n1qC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1802_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	SER C 119 THR C 117 VAL C 115 ILE B 337	None	1.10A	5vkqA-5n1qC: undetectable 5vkqB-5n1qC: undetectable	5vkqA-5n1qC: 9.64 5vkqB-5n1qC: 9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	SER C 119 THR C 117 VAL C 115 ILE B 337	None	1.08A	5vkqB-5n1qC: undetectable 5vkqC-5n1qC: undetectable	5vkqB-5n1qC: 9.64 5vkqC-5n1qC: 9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	SER C 119 THR C 117 VAL C 115 ILE B 337	None	1.09A	5vkqC-5n1qC: undetectable 5vkqD-5n1qC: undetectable	5vkqC-5n1qC: 9.64 5vkqD-5n1qC: 9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CLX_A_SAMA401_0 (O-METHYLTRANSFERASE)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	5 / 12	ALA B 328 GLY B 373 GLY B 371 VAL B 393 ASP B 400	None	1.15A	6clxA-5n1qB: undetectable	6clxA-5n1qB: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 6	ASP B 278 VAL B 280 GLU B 277 ALA B 258	None	1.24A	6djzB-5n1qB: undetectable	6djzB-5n1qB: 19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWD_A_GLYA715_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	5n1q	METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA (Methanothermococ cus thermolithotroph icus)	4 / 6	ASP B 100 SER B 118 ARG B 120 ARG B 44	None	1.23A	6dwdA-5n1qB: undetectable 6dwdC-5n1qB: undetectable	6dwdA-5n1qB: 21.05 6dwdC-5n1qB: 21.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DYR_A_TOPA407_1","DIHYDROFOLATE REDUCTASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"ILE B 160;ALA B 137;ILE B  85;ILE B 156;THR B 134","None","1.07A","1dyrA-5n1qB:undetectable","1dyrA-5n1qB:17.41"],["1ETR_H_MITH1_1","EPSILON-THROMBIN","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"HIS B 199;TYR B 200;LEU B 178;ASP B 169;GLY B 180","None","0.93A","1etrH-5n1qB:undetectable","1etrH-5n1qB:21.22"],["2BLA_A_CP6A302_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"ILE B  78;ALA B  82;ASN B  49;ILE B 175;ILE B  53","None","1.28A","2blaA-5n1qB:undetectable","2blaA-5n1qB:20.44"],["2CD2_A_FOLA307_0","DIHYDROFOLATE REDUCTASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"ILE B 160;ALA B 137;ILE B  85;ILE B 156;THR B 134","None","1.00A","2cd2A-5n1qB:undetectable","2cd2A-5n1qB:17.41"],["2G72_B_SAMB2002_0","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"TYR B 334;LEU B 310;ILE B 315;VAL B 316;VAL B 267","None","1.27A","2g72B-5n1qB:undetectable","2g72B-5n1qB:22.56"],["2HYY_B_STIB600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"LEU B  93;VAL B  48;ILE B  85;MET B 131","None","1.07A","2hyyB-5n1qB:undetectable","2hyyB-5n1qB:21.16"],["2HYY_B_STIB600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"VAL B  79;VAL B  48;ILE B 142;MET B 131","None","1.25A","2hyyB-5n1qB:undetectable","2hyyB-5n1qB:21.16"],["2QXS_A_RALA600_1","ESTROGEN RECEPTOR","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"ALA B 308;LEU B 310;LEU B 239;ILE B  27;PRO B 392","None","1.07A","2qxsA-5n1qB:undetectable","2qxsA-5n1qB:22.10"],["2QXS_B_RALB600_1","ESTROGEN RECEPTOR","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"ALA B 308;LEU B 310;LEU B 239;ILE B  27;PRO B 392","None","1.05A","2qxsB-5n1qB:undetectable","2qxsB-5n1qB:22.10"],["3A27_A_SAMA250_1","UNCHARACTERIZED PROTEIN MJ1557","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus;Methanothermococcus thermolithotrophicus",3,"MET C  62;GLU B 409;ASN B 198","None","1.08A","3a27A-5n1qC:undetectable","3a27A-5n1qC:21.57"],["3ADS_A_IMNA2_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"ILE B  42;ILE B 175;TYR B 170;LEU B 192","None","1.02A","3adsA-5n1qB:undetectable","3adsA-5n1qB:20.22"],["3APV_A_TP0A190_1","ALPHA-1-ACID GLYCOPROTEIN 2","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"TYR B 127;PHE B 425;PHE B 214;SER B 177;TYR B 419","None","1.50A","3apvA-5n1qB:undetectable","3apvA-5n1qB:16.89"],["3DTU_C_DXCC576_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"PRO B 392;ALA B 396;ALA B 399;THR B 330","None","0.83A","3dtuC-5n1qB:undetectable;3dtuD-5n1qB:undetectable","3dtuC-5n1qB:20.61;3dtuD-5n1qB:20.70"],["3JZJ_A_ACRA405_1","ACARBOSE\/MALTOSE BINDING PROTEIN GACH","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"GLY B 240;GLU B 219;ALA B 222;ASP B 348;GLY B 377","None","1.16A","3jzjA-5n1qB:undetectable","3jzjA-5n1qB:24.66"],["3K5V_A_STIA2_2","TYROSINE-PROTEIN KINASE ABL1","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"VAL B  79;VAL B  48;ILE B 142;MET B 131","None","1.21A","3k5vA-5n1qB:undetectable","3k5vA-5n1qB:21.88"],["3KEE_B_30BB500_1","GENOME POLYPROTEIN","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",5,"HIS B 364;ASP C 116;VAL B 381;GLY B 370;ALA B 328","None","1.09A","3keeB-5n1qB:undetectable","3keeB-5n1qB:18.33"],["3NU3_B_478B401_2","PROTEASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"GLY B 354;ALA B 356;VAL B 327;PRO B 392;ILE B 331","None","0.90A","3nu3B-5n1qB:undetectable","3nu3B-5n1qB:14.43"],["3QXV_D_MTXD2000_2","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",3,"LEU C  31;ARG C 151;ASN C  17","None","0.77A","3qxvD-5n1qC:undetectable","3qxvD-5n1qC:17.25"],["3S3N_A_DLUA398_1","PFV INTEGRASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",4,"ASP C 204;GLY C 206;TYR C 190;PRO C 202","None","1.00A","3s3nA-5n1qC:undetectable","3s3nA-5n1qC:21.69"],["3T3S_E_9PLE1_1","CYTOCHROME P450 2A13","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",4,"PHE C 147;ALA C  97;PHE C  90;ALA C  91","None","0.98A","3t3sE-5n1qC:undetectable","3t3sE-5n1qC:18.99"],["3TKG_C_ROCC901_2","PROTEASE;PROTEASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"LEU B 246;GLY B 435;ALA B 436;ILE B 443;ILE B  27","None","0.97A","3tkgD-5n1qB:undetectable","3tkgD-5n1qB:14.43"],["3UQ6_A_ADNA401_2","ADENOSINE KINASE, PUTATIVE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",4,"LEU B 332;ALA B 328;MET C 109;ASN B 317","None","1.35A","3uq6A-5n1qB:undetectable","3uq6A-5n1qB:22.20"],["4HFP_B_15UB402_1","PROTHROMBIN","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"HIS B 199;TYR B 200;LEU B 178;ASP B 169;GLY B 180","None","1.08A","4hfpB-5n1qB:undetectable","4hfpB-5n1qB:21.28"],["4L39_B_SALB601_1","4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"THR B  45;ILE B 422;THR B 203;GLY B 416","None","0.95A","4l39B-5n1qB:undetectable","4l39B-5n1qB:19.39"],["4PEV_B_ADNB501_1","MEMBRANE LIPOPROTEIN FAMILY PROTEIN","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",5,"VAL C 238;SER B 289;PHE B 291;GLY B 343;GLY C  10","None","1.22A","4pevB-5n1qC:undetectable","4pevB-5n1qC:21.48"],["4Q5M_A_ROCA1101_1","PROTEASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",5,"GLY B 346;ILE B 331;VAL B 267;ARG C 245;THR B 355","None","1.04A","4q5mA-5n1qB:undetectable","4q5mA-5n1qB:19.59"],["4QN9_B_DXCB610_0","N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",3,"GLY B 371;PRO B 372;ALA B 328","None","0.56A","4qn9B-5n1qB:undetectable","4qn9B-5n1qB:23.11"],["4RZV_A_032A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"ILE B 315;VAL B 314;PHE B 375;CYH B 398","None","1.34A","4rzvA-5n1qB:undetectable","4rzvA-5n1qB:19.73"],["4XQG_A_AG2A505_1","HOMOSPERMIDINE SYNTHASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"ARG B 426;ASP B 423;PHE B 425;VAL B 418","None","1.16A","4xqgA-5n1qB:undetectable","4xqgA-5n1qB:22.73"],["5EB5_A_010A609_0","HNL ISOENZYME 5","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"ALA B 141;ALA B 137;LEU B 138;LEU B  50;VAL B 114","None","1.22A","5eb5A-5n1qB:undetectable","5eb5A-5n1qB:23.20"],["5EUM_B_ACTB603_0","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus;Methanothermococcus thermolithotrophicus",4,"ALA B 320;ASN B 317;ARG C 113;ILE C  76","None","1.41A","5eumB-5n1qB:0.6","5eumB-5n1qB:21.83"],["5HM8_A_ADNA501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.20A","5hm8A-5n1qB:undetectable","5hm8A-5n1qB:23.85"],["5HM8_B_ADNB501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.21A","5hm8B-5n1qB:undetectable","5hm8B-5n1qB:23.85"],["5HM8_C_ADNC501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.21A","5hm8C-5n1qB:undetectable","5hm8C-5n1qB:23.85"],["5HM8_D_ADND501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.20A","5hm8D-5n1qB:undetectable","5hm8D-5n1qB:23.85"],["5HM8_E_ADNE501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.21A","5hm8E-5n1qB:undetectable","5hm8E-5n1qB:23.85"],["5HM8_F_ADNF501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.21A","5hm8F-5n1qB:undetectable","5hm8F-5n1qB:23.85"],["5HM8_G_ADNG501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.10A","5hm8G-5n1qB:undetectable","5hm8G-5n1qB:23.85"],["5HM8_H_ADNH501_2","ADENOSYLHOMOCYSTEINASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"GLU B 225;THR B 221;GLU B 219;LEU B 178","None","1.21A","5hm8H-5n1qB:undetectable","5hm8H-5n1qB:23.85"],["5MVN_C_PFLC407_1","PROTON-GATED ION CHANNEL","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",5,"TYR B 333;TYR C 102;TYR C 108;THR C 117;ILE C 126","None","1.43A","5mvnC-5n1qB:1.0","5mvnC-5n1qB:10.34"],["5MVN_D_PFLD410_1","PROTON-GATED ION CHANNEL","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",5,"TYR B 333;TYR C 102;TYR C 108;THR C 117;ILE C 126","None","1.43A","5mvnD-5n1qB:undetectable","5mvnD-5n1qB:10.34"],["5ODC_G_ACTG703_0","HETERODISULFIDE REDUCTASE, SUBUNIT A;HETERODISULFIDE REDUCTASE, SUBUNIT B;HETERODISULFIDE REDUCTASE, SUBUNIT C","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",4,"GLU C 134;ARG C  46;ARG C  84;GLU C 130","None","1.24A","5odcB-5n1qC:0.0;5odcC-5n1qC:0.0;5odcG-5n1qC:0.0","5odcB-5n1qC:24.31;5odcC-5n1qC:19.48;5odcG-5n1qC:16.77"],["5PHH_A_LDPA414_1","LYSINE-SPECIFIC DEMETHYLASE 4D","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus",4,"ARG C  19;ALA C  11;LEU C 234;TYR C 221","None","1.12A","5phhA-5n1qC:undetectable","5phhA-5n1qC:19.63"],["5VKQ_B_PCFB1802_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus;Methanothermococcus thermolithotrophicus",4,"SER C 119;THR C 117;VAL C 115;ILE B 337","None","1.10A","5vkqA-5n1qC:undetectable;5vkqB-5n1qC:undetectable","5vkqA-5n1qC:9.64;5vkqB-5n1qC:9.64"],["5VKQ_C_PCFC1803_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus;Methanothermococcus thermolithotrophicus",4,"SER C 119;THR C 117;VAL C 115;ILE B 337","None","1.08A","5vkqB-5n1qC:undetectable;5vkqC-5n1qC:undetectable","5vkqB-5n1qC:9.64;5vkqC-5n1qC:9.64"],["5VKQ_D_PCFD1803_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA;METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT GAMMA","Methanothermococcus thermolithotrophicus;Methanothermococcus thermolithotrophicus",4,"SER C 119;THR C 117;VAL C 115;ILE B 337","None","1.09A","5vkqC-5n1qC:undetectable;5vkqD-5n1qC:undetectable","5vkqC-5n1qC:9.64;5vkqD-5n1qC:9.64"],["6CLX_A_SAMA401_0","O-METHYLTRANSFERASE","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",5,"ALA B 328;GLY B 373;GLY B 371;VAL B 393;ASP B 400","None","1.15A","6clxA-5n1qB:undetectable","6clxA-5n1qB:22.06"],["6DJZ_B_GMJB301_1","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"ASP B 278;VAL B 280;GLU B 277;ALA B 258","None","1.24A","6djzB-5n1qB:undetectable","6djzB-5n1qB:19.68"],["6DWD_A_GLYA715_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","5n1q","METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS SUBUNIT BETA","Methanothermococcus thermolithotrophicus",4,"ASP B 100;SER B 118;ARG B 120;ARG B  44","None","1.23A","6dwdA-5n1qB:undetectable;6dwdC-5n1qB:undetectable","6dwdA-5n1qB:21.05;6dwdC-5n1qB:21.05"]]