SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		4 / 4 SER M  35
VAL M  64
PHE M  26
VAL M  87
 None
 1.40A 1o86A-5n1tM:
undetectable		 1o86A-5n1tM:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		5 / 12 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.77A 1ya3C-5n1tM:
undetectable		 1ya3C-5n1tM:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		5 / 12 ARG A 290
GLY A 320
GLY A  41
GLY A  40
ILE A  39
 None
FAD  A 501 (-3.2A)
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.1A)
FAD  A 501 ( 4.8A)
 0.82A 2avvA-5n1tA:
undetectable		 2avvA-5n1tA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 7 LEU A 231
PHE A 232
GLY A 235
THR A 238
 None
 0.90A 2bdmA-5n1tA:
undetectable		 2bdmA-5n1tA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		5 / 12 MET A 328
ALA A 325
VAL A 341
GLY A 326
ILE A 387
 None
 1.19A 2dcfA-5n1tA:
undetectable		 2dcfA-5n1tA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		5 / 12 VAL A 276
ASN A 278
ILE A 280
GLN A 165
ALA A 159
 None
 1.19A 3ddyA-5n1tA:
undetectable		 3ddyA-5n1tA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		5 / 12 ILE A 319
GLY A 320
ALA A 331
PRO A 136
ALA A 325
 None
FAD  A 501 (-3.2A)
FAD  A 501 (-3.5A)
FAD  A 501 (-4.5A)
None
 1.02A 3jb1A-5n1tA:
3.8		 3jb1A-5n1tA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		4 / 7 ILE M  49
LEU M  58
ALA M 119
ALA M 101
 None
 0.90A 3r9tB-5n1tM:
undetectable		 3r9tB-5n1tM:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		3 / 3 ARG A 141
TRP A 300
GLY A 299
 None
 0.97A 4e7cA-5n1tA:
1.7		 4e7cA-5n1tA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		5 / 12 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.62A 4fn9A-5n1tM:
undetectable		 4fn9A-5n1tM:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		5 / 12 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.58A 4fn9B-5n1tM:
undetectable		 4fn9B-5n1tM:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 6 ARG A 200
GLY A 196
GLU A 199
GLN A 283
 FAD  A 501 ( 4.8A)
FAD  A 501 ( 4.7A)
None
None
 1.20A 4g0vB-5n1tA:
undetectable		 4g0vB-5n1tA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		5 / 12 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.71A 4ltwA-5n1tM:
undetectable		 4ltwA-5n1tM:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 7 ILE A  64
LEU A 121
ASP A 123
ASP A 122
 None
 1.11A 4mmcA-5n1tA:
undetectable		 4mmcA-5n1tA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 5 ILE A 127
VAL A  37
ILE A  39
VAL A 119
 None
None
FAD  A 501 ( 4.8A)
None
 0.67A 4xdtA-5n1tA:
undetectable		 4xdtA-5n1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5n1t CYTOCHROME C
FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 6 SER B  29
GLY A 414
ASP A 417
GLY B  24
 None
 0.79A 5cdpA-5n1tB:
undetectable
5cdpB-5n1tB:
undetectable		 5cdpA-5n1tB:
9.94
5cdpB-5n1tB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		5 / 12 VAL A 258
TYR A 148
ALA A 185
VAL A 255
MET A 176
 None
 1.19A 5hv1A-5n1tA:
undetectable		 5hv1A-5n1tA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 8 ILE A 288
ARG A 290
GLY A 293
THR A 295
 FAD  A 501 (-3.3A)
None
None
None
 0.84A 5hwaA-5n1tA:
undetectable		 5hwaA-5n1tA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 8 HIS A 210
HIS A 206
LEU A 239
GLY A 369
 None
 0.96A 5m8rC-5n1tA:
undetectable		 5m8rC-5n1tA:
11.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N1T_W_CUW201_0
(COPC)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		3 / 3 HIS M   1
ASP M 110
HIS M 112
 None
 0.40A 5n1tW-5n1tM:
23.7		 5n1tW-5n1tM:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		3 / 3 LYS M   1
HIS M   3
HIS M   1
 None
 1.19A 5oexA-5n1tM:
undetectable		 5oexA-5n1tM:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		3 / 3 LYS M   1
HIS M   3
HIS M   1
 None
 1.12A 5oexB-5n1tM:
undetectable		 5oexB-5n1tM:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		3 / 3 LYS M   1
HIS M   3
HIS M   1
 None
 1.12A 5oexC-5n1tM:
undetectable		 5oexC-5n1tM:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5n1t COPC
(Thioalkalivibrio
paradoxus) 		3 / 3 LYS M   1
HIS M   3
HIS M   1
 None
 1.17A 5oexD-5n1tM:
undetectable		 5oexD-5n1tM:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 7 VAL A 265
ILE A 219
SER A 269
THR A 267
 None
 0.99A 5vkqA-5n1tA:
undetectable
5vkqD-5n1tA:
undetectable		 5vkqA-5n1tA:
13.68
5vkqD-5n1tA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 7 SER A 269
THR A 267
VAL A 265
ILE A 219
 None
 1.02A 5vkqA-5n1tA:
undetectable
5vkqB-5n1tA:
undetectable		 5vkqA-5n1tA:
13.68
5vkqB-5n1tA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 8 SER A 269
THR A 267
VAL A 265
ILE A 219
 None
 0.98A 5vkqB-5n1tA:
undetectable
5vkqC-5n1tA:
undetectable		 5vkqB-5n1tA:
13.68
5vkqC-5n1tA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 7 SER A 269
THR A 267
VAL A 265
ILE A 219
 None
 1.00A 5vkqC-5n1tA:
undetectable
5vkqD-5n1tA:
undetectable		 5vkqC-5n1tA:
13.68
5vkqD-5n1tA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		5 / 11 ILE A 219
PRO A 186
PRO A 197
SER A 202
LEU A 203
 None
 1.44A 6dlzA-5n1tA:
3.1
6dlzD-5n1tA:
3.0		 6dlzA-5n1tA:
21.43
6dlzD-5n1tA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		5 / 11 ILE A 219
PRO A 186
PRO A 197
SER A 202
LEU A 203
 None
 1.44A 6dm1A-5n1tA:
3.2
6dm1D-5n1tA:
3.0		 6dm1A-5n1tA:
21.43
6dm1D-5n1tA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
(Thioalkalivibrio
paradoxus) 		4 / 6 ASP A 354
GLN A 306
ASN A 304
LEU A 382
 None
 1.25A 6ekuA-5n1tA:
undetectable		 6ekuA-5n1tA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
CYTOCHROME C
(Thioalkalivibrio
paradoxus;
Thioalkalivibrio
paradoxus) 		4 / 8 SER B  50
MET B  53
SER A 337
VAL A 379
 HEC  B 901 (-4.3A)
HEC  B 901 (-2.2A)
None
None
 0.96A 6giqL-5n1tB:
undetectable
6giqP-5n1tB:
undetectable
6giqT-5n1tB:
undetectable		 6giqL-5n1tB:
12.76
6giqP-5n1tB:
18.93
6giqT-5n1tB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE
CYTOCHROME C
(Thioalkalivibrio
paradoxus;
Thioalkalivibrio
paradoxus) 		5 / 11 ALA B   8
HIS B  71
GLY B   4
PHE A  55
ALA A 344
 None
 1.32A 6ieyA-5n1tB:
undetectable
6ieyB-5n1tB:
undetectable		 6ieyA-5n1tB:
undetectable
6ieyB-5n1tB:
undetectable