SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 ALA A 166
VAL A 213
TRP A 229
 None
 0.80A 1av2A-5n28A:
undetectable
1av2B-5n28A:
undetectable		 1av2A-5n28A:
2.32
1av2B-5n28A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 TRP A 229
ALA A 166
VAL A 213
 None
 0.77A 1av2C-5n28A:
undetectable
1av2D-5n28A:
undetectable		 1av2C-5n28A:
2.32
1av2D-5n28A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 8 SER C 121
SER C 163
HIS C 162
ARG A 403
 None
 1.17A 1eqbA-5n28C:
undetectable
1eqbB-5n28C:
undetectable		 1eqbA-5n28C:
21.45
1eqbB-5n28C:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 8 SER C 121
SER C 163
HIS C 162
ARG A 403
 None
 1.17A 1eqbA-5n28C:
undetectable
1eqbB-5n28C:
undetectable		 1eqbA-5n28C:
21.45
1eqbB-5n28C:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 8 SER C 121
SER C 163
HIS C 162
ARG A 403
 None
 1.17A 1eqbC-5n28C:
undetectable
1eqbD-5n28C:
undetectable		 1eqbC-5n28C:
21.45
1eqbD-5n28C:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 8 SER C 121
SER C 163
HIS C 162
ARG A 403
 None
 1.17A 1eqbC-5n28C:
undetectable
1eqbD-5n28C:
undetectable		 1eqbC-5n28C:
21.45
1eqbD-5n28C:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 THR A 380
LEU C 235
LEU C 234
ILE C 241
LEU A 431
 None
 1.14A 1errB-5n28A:
undetectable		 1errB-5n28A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 HIS B 199
TYR B 200
LEU B 178
ASP B 169
GLY B 180
 None
 0.88A 1etrH-5n28B:
undetectable		 1etrH-5n28B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		3 / 3 PHE C 147
TYR C 179
PRO C 149
 None
 1.06A 1mcnA-5n28C:
undetectable
1mcnB-5n28C:
undetectable
1mcnP-5n28C:
undetectable		 1mcnA-5n28C:
20.74
1mcnB-5n28C:
20.74
1mcnP-5n28C:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		3 / 3 PHE C 147
TYR C 190
PRO C 149
 None
 0.92A 1mcnA-5n28C:
undetectable
1mcnB-5n28C:
undetectable
1mcnP-5n28C:
undetectable		 1mcnA-5n28C:
20.74
1mcnB-5n28C:
20.74
1mcnP-5n28C:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 THR A 296
LEU A 289
PHE A 100
VAL A 292
ALA A 311
 None
 1.05A 1q23H-5n28A:
undetectable
1q23I-5n28A:
undetectable		 1q23H-5n28A:
16.64
1q23I-5n28A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		3 / 3 TYR A 490
ARG C 245
GLN A 453
 TRX  A 429 ( 4.8A)
None
None
 0.98A 1tw4A-5n28A:
undetectable		 1tw4A-5n28A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 5 GLU A 389
THR A 380
LEU A 384
LEU A 381
 None
 1.15A 1u18B-5n28A:
undetectable		 1u18B-5n28A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 ALA A 166
VAL A 213
TRP A 229
 None
 0.80A 1w5uA-5n28A:
undetectable
1w5uB-5n28A:
undetectable		 1w5uA-5n28A:
2.32
1w5uB-5n28A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 TRP A 229
ALA A 166
VAL A 213
 None
 0.69A 1w5uA-5n28A:
undetectable
1w5uB-5n28A:
undetectable		 1w5uA-5n28A:
2.32
1w5uB-5n28A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 5 PHE A 100
LEU A 289
PHE A 531
SER A 339
 None
 1.10A 1wrkB-5n28A:
undetectable		 1wrkB-5n28A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 7 PHE A 100
LEU A 289
PHE A 531
SER A 339
 None
 1.10A 1wrlA-5n28A:
undetectable
1wrlB-5n28A:
undetectable		 1wrlA-5n28A:
10.64
1wrlB-5n28A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.89A 2avvD-5n28B:
undetectable		 2avvD-5n28B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 SER A 414
ASP A 347
CYH A 386
 None
 1.00A 2br4E-5n28A:
undetectable		 2br4E-5n28A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 11 ARG A 537
ALA A 535
ALA A  37
GLU A  41
LEU A  89
 None
 0.97A 2bxeB-5n28A:
2.8		 2bxeB-5n28A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 7 PHE B 151
ARG B  72
ASP B 149
ASP B 152
 None
 1.22A 2e5dA-5n28B:
undetectable
2e5dB-5n28B:
undetectable		 2e5dA-5n28B:
20.12
2e5dB-5n28B:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 7 ASP B 152
PHE B 151
ARG B  72
ASP B 149
 None
 1.21A 2e5dA-5n28B:
undetectable
2e5dB-5n28B:
undetectable		 2e5dA-5n28B:
20.12
2e5dB-5n28B:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		5 / 12 TYR B 295
LEU B 345
PHE C   7
VAL B 293
TYR C   3
 None
 1.33A 2g70A-5n28B:
undetectable		 2g70A-5n28B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		5 / 12 TYR B 295
LEU B 345
PHE C   7
VAL B 293
TYR C   3
 None
 1.37A 2g70B-5n28B:
undetectable		 2g70B-5n28B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		5 / 12 TYR B 295
LEU B 345
PHE C   7
VAL B 293
TYR C   3
 None
 1.33A 2g72A-5n28B:
undetectable		 2g72A-5n28B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 TYR B 335
LEU B 311
ILE B 316
VAL B 317
VAL B 268
 None
 1.30A 2g72B-5n28B:
undetectable		 2g72B-5n28B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 ALA A 166
VAL A 213
TRP A 229
 None
 0.69A 2izqA-5n28A:
undetectable
2izqB-5n28A:
undetectable		 2izqA-5n28A:
2.32
2izqB-5n28A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 TRP A 229
ALA A 166
VAL A 213
 None
 0.88A 2izqC-5n28A:
undetectable
2izqD-5n28A:
undetectable		 2izqC-5n28A:
2.32
2izqD-5n28A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 7 ASP A 172
THR A 207
ILE A 179
ASN A 133
 None
 1.03A 2jc9A-5n28A:
2.1		 2jc9A-5n28A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.93A 2nmyB-5n28B:
undetectable		 2nmyB-5n28B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		4 / 4 PRO C 202
ASP C  38
ASP C  36
ASP C 204
 None
 1.40A 2nyuA-5n28C:
undetectable		 2nyuA-5n28C:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 7 MET A 326
ILE B 381
ARG B 384
GLY A 474
 AGM  A 274 (-3.9A)
AGM  A 274 (-3.7A)
None
None
 1.20A 2pnjB-5n28A:
undetectable		 2pnjB-5n28A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.94A 2pymB-5n28B:
undetectable		 2pymB-5n28B:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.91A 2pynB-5n28B:
undetectable		 2pynB-5n28B:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.91A 2q63B-5n28B:
undetectable		 2q63B-5n28B:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.91A 2qakB-5n28B:
undetectable		 2qakB-5n28B:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 ALA B 309
LEU B 311
LEU B 239
ILE B  27
PRO B 393
 None
 1.09A 2qxsA-5n28B:
undetectable		 2qxsA-5n28B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 ALA B 309
LEU B 311
LEU B 239
ILE B  27
PRO B 393
 None
 1.07A 2qxsB-5n28B:
undetectable		 2qxsB-5n28B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 8 ARG B 352
LYS B 387
SER A 461
ASP A 465
 None
 1.19A 2rk8A-5n28B:
undetectable		 2rk8A-5n28B:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 7 ARG B 352
LYS B 387
SER A 461
ASP A 465
 None
 1.17A 2rk8B-5n28B:
undetectable		 2rk8B-5n28B:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 8 SER C 121
SER C 163
HIS C 162
ARG A 403
 None
 1.24A 2vmyA-5n28C:
undetectable
2vmyB-5n28C:
undetectable		 2vmyA-5n28C:
22.22
2vmyB-5n28C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 10 ILE A 239
TYR A 135
LEU A 119
VAL A 118
LEU A 123
 None
 1.27A 2w98A-5n28A:
undetectable		 2w98A-5n28A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 8 ILE A 239
TYR A 135
LEU A 119
VAL A 118
LEU A 123
 None
 1.29A 2w98B-5n28A:
undetectable		 2w98B-5n28A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 4 GLU A  41
ARG A  38
ASN A  93
ASP A  88
 None
 1.23A 2zq9A-5n28A:
1.3		 2zq9A-5n28A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 6 GLN A 233
GLY A 146
CYH A 164
TRP A 229
 F43  A 604 (-4.0A)
None
None
None
 1.25A 3ai8B-5n28A:
undetectable		 3ai8B-5n28A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 9 ILE C  76
GLY C  78
SER C 137
GLU C 130
LEU C 133
 None
 1.11A 3ai9X-5n28C:
undetectable		 3ai9X-5n28C:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		4 / 8 ARG C 129
GLY C  78
LEU C  59
PRO C  75
 None
 1.13A 3bgdB-5n28C:
undetectable		 3bgdB-5n28C:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.90A 3cyxA-5n28B:
undetectable		 3cyxA-5n28B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.94A 3d1xB-5n28B:
undetectable		 3d1xB-5n28B:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 9 LEU B 238
ILE B 434
GLY B 436
PRO B  23
ILE B  27
 None
 1.09A 3ekqB-5n28B:
undetectable		 3ekqB-5n28B:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 ASN A 140
HIS A 141
VAL A 148
 None
None
F43  A 604 (-3.5A)
 0.85A 3elzB-5n28A:
undetectable		 3elzB-5n28A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 9 VAL A 213
ILE A 234
VAL A 110
VAL A 263
GLN A 265
 None
None
None
MHS  A 260 ( 4.7A)
None
 1.44A 3fi0F-5n28A:
undetectable		 3fi0F-5n28A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		3 / 3 MET B 218
MET B 209
PHE B 426
 None
 1.32A 3gn8A-5n28B:
undetectable		 3gn8A-5n28B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 TYR A 317
GLY A 287
ALA A 491
ILE A 284
PRO A 509
 None
 1.11A 3jayA-5n28A:
undetectable		 3jayA-5n28A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 GLY B 240
GLU B 219
ALA B 222
ASP B 349
GLY B 378
 None
 1.16A 3jzjA-5n28B:
undetectable		 3jzjA-5n28B:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 HIS B 365
ASP C 116
VAL B 382
GLY B 371
ALA B 329
 None
 1.11A 3keeB-5n28B:
undetectable		 3keeB-5n28B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 10 PHE C 147
GLY C 153
PHE C  90
ILE C  34
PHE C 140
 None
 1.43A 3ko0L-5n28C:
undetectable
3ko0N-5n28C:
undetectable		 3ko0L-5n28C:
14.94
3ko0N-5n28C:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 TRP A 229
ALA A 166
VAL A 213
 None
 0.94A 3l8lA-5n28A:
undetectable
3l8lB-5n28A:
undetectable		 3l8lA-5n28A:
2.32
3l8lB-5n28A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 TRP A 229
ALA A 166
VAL A 213
 None
 0.81A 3l8lC-5n28A:
undetectable
3l8lD-5n28A:
undetectable		 3l8lC-5n28A:
2.32
3l8lD-5n28A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.95A 3ndtC-5n28B:
undetectable		 3ndtC-5n28B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.93A 3nduD-5n28B:
undetectable		 3nduD-5n28B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 11 GLY B 355
ALA B 357
VAL B 328
PRO B 393
ILE B 332
 None
 0.90A 3nu3B-5n28B:
undetectable		 3nu3B-5n28B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.89A 3oxxA-5n28B:
undetectable		 3oxxA-5n28B:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.97A 3oxxC-5n28B:
undetectable		 3oxxC-5n28B:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 9 TYR B 334
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.44A 3p4wA-5n28B:
undetectable		 3p4wA-5n28B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 1.00A 3pwrA-5n28B:
undetectable		 3pwrA-5n28B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.95A 3pwrB-5n28B:
undetectable		 3pwrB-5n28B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 TYR A 430
GLY A 425
SER A 468
TYR A 477
CYH A 454
 TRX  A 429 ( 3.6A)
None
None
None
None
 1.50A 3rq4A-5n28A:
2.9		 3rq4A-5n28A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 11 LEU A  89
VAL A  84
SER A 312
THR A  80
PHE A 522
 None
 1.35A 3tbgA-5n28A:
2.4		 3tbgA-5n28A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 GLN A 433
PHE A 445
GLY A 400
ALA A 404
GLY A 485
 TRX  A 429 ( 4.3A)
GL3  A 447 (-4.1A)
MGN  A 402 ( 4.4A)
None
TRX  A 429 ( 4.5A)
 1.14A 3tegA-5n28A:
4.0		 3tegA-5n28A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.94A 3tkgD-5n28B:
undetectable		 3tkgD-5n28B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 GLY A 428
GLY A 425
ILE A 493
ALA A 376
LEU A 435
 TRX  A 429 ( 2.4A)
None
None
None
None
 1.15A 3uj7B-5n28A:
undetectable		 3uj7B-5n28A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 LEU B 333
ALA B 329
MET C 109
ASN B 318
 None
 1.30A 3uq6A-5n28B:
undetectable		 3uq6A-5n28B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 4 LEU B 179
GLY B 180
MET B 131
PHE B 420
 None
 1.26A 3vaqB-5n28B:
undetectable		 3vaqB-5n28B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 6 PRO A 281
GLY A 282
ASN A 476
LEU A 270
 None
None
AGM  A 274 ( 3.6A)
AGM  A 274 ( 3.8A)
 0.84A 3zqtA-5n28A:
undetectable		 3zqtA-5n28A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 10 GLY B  63
ALA B 173
GLY B 172
HIS B 157
VAL B 167
 None
 1.17A 4c5nB-5n28B:
undetectable		 4c5nB-5n28B:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 10 GLY B  64
ALA B 173
GLY B 172
HIS B 157
VAL B 167
 None
 1.28A 4c5nB-5n28B:
undetectable		 4c5nB-5n28B:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 ALA B 159
ILE B 175
LEU B 138
ASN B 174
 None
 1.21A 4g19A-5n28B:
undetectable		 4g19A-5n28B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 3 GLU A 530
ASP A 523
ASP A 103
 None
 0.79A 4gc9A-5n28A:
undetectable		 4gc9A-5n28A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 HIS B 199
TYR B 200
LEU B 178
ASP B 169
GLY B 180
 None
 0.95A 4hfpB-5n28B:
undetectable		 4hfpB-5n28B:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.95A 4jecB-5n28B:
undetectable		 4jecB-5n28B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 7 THR B  45
ILE B 423
THR B 203
GLY B 417
 None
 0.96A 4l39B-5n28B:
undetectable		 4l39B-5n28B:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 9 VAL B 348
ILE B  27
ALA B 248
VAL B 312
ALA B 308
 None
 1.26A 4oqrA-5n28B:
undetectable		 4oqrA-5n28B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 ILE B 316
VAL B 315
PHE B 376
CYH B 399
 None
 1.36A 4rzvA-5n28B:
undetectable		 4rzvA-5n28B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		5 / 12 GLY B 355
TYR A 448
SER B 330
ALA B 390
ASN B 336
 None
 1.25A 4ymgA-5n28B:
undetectable		 4ymgA-5n28B:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		5 / 12 GLY B 355
TYR A 448
SER B 330
ALA B 390
ASN B 336
 None
 1.19A 4ymgB-5n28B:
undetectable		 4ymgB-5n28B:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		3 / 4 ARG A 105
GLY A 224
GLU A 280
 K  A 605 ( 4.0A)
None
None
 0.62A 4z2dB-5n28A:
undetectable
4z2dC-5n28A:
undetectable		 4z2dB-5n28A:
21.38
4z2dC-5n28A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 7 ARG B 384
ARG A 463
ASP B 228
TYR B 190
 None
 1.24A 5a06A-5n28B:
undetectable		 5a06A-5n28B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 7 ARG B 384
ARG A 463
ASP B 228
TYR B 190
 None
 1.26A 5a06B-5n28B:
undetectable		 5a06B-5n28B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 7 ARG B 384
ARG A 463
ASP B 228
TYR B 190
 None
 1.23A 5a06C-5n28B:
undetectable		 5a06C-5n28B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 7 ARG B 384
ARG A 463
ASP B 228
TYR B 190
 None
 1.23A 5a06D-5n28B:
undetectable		 5a06D-5n28B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 7 ARG B 384
ARG A 463
ASP B 228
TYR B 190
 None
 1.25A 5a06E-5n28B:
undetectable		 5a06E-5n28B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 5 PHE A 531
ASP A 523
PHE A 524
PHE A 522
 None
 1.10A 5a1rA-5n28A:
undetectable		 5a1rA-5n28A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 TYR B 368
GLY A 331
TYR A 335
GLY A 485
 TP7  A 603 (-4.2A)
None
None
TRX  A 429 ( 4.5A)
 1.02A 5ayfA-5n28B:
undetectable		 5ayfA-5n28B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 11 ALA B 141
ALA B 137
LEU B 138
LEU B  50
VAL B 114
 None
 1.24A 5eb5A-5n28B:
undetectable		 5eb5A-5n28B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 ILE A 413
GLY A 352
SER A 349
PHE A 348
LEU A 435
 None
 1.03A 5ergB-5n28A:
undetectable		 5ergB-5n28A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 4 ALA B 321
ASN B 318
ARG C 113
ILE C  76
 None
 1.44A 5eumB-5n28B:
0.6		 5eumB-5n28B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.20A 5hm8A-5n28B:
undetectable		 5hm8A-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.20A 5hm8B-5n28B:
undetectable		 5hm8B-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.20A 5hm8C-5n28B:
undetectable		 5hm8C-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.20A 5hm8D-5n28B:
undetectable		 5hm8D-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.20A 5hm8E-5n28B:
undetectable		 5hm8E-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.20A 5hm8F-5n28B:
undetectable		 5hm8F-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.09A 5hm8G-5n28B:
undetectable		 5hm8G-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		4 / 5 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.20A 5hm8H-5n28B:
undetectable		 5hm8H-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 PRO A 367
VAL A 371
ILE A 375
ALA A 376
GLY A 364
 None
 0.82A 5j2tC-5n28A:
undetectable		 5j2tC-5n28A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 ALA A 115
LEU A 119
ALA A 231
GLY A 235
SER A 237
 None
 1.11A 5jglA-5n28A:
2.1		 5jglA-5n28A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 ALA A 115
LEU A 119
ALA A 231
GLY A 235
SER A 237
 None
 1.09A 5jglB-5n28A:
undetectable		 5jglB-5n28A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 ILE B 175
ILE B 160
VAL B  48
ASN B  55
GLU B  54
 None
 1.10A 5lg3E-5n28B:
undetectable		 5lg3E-5n28B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 ILE B 175
ILE B 160
VAL B  48
ASN B  55
GLU B  54
 None
 1.21A 5lg3J-5n28B:
undetectable		 5lg3J-5n28B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_C_PFLC407_1
(PROTON-GATED ION
CHANNEL)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 9 TYR B 334
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.36A 5mvnC-5n28B:
1.1		 5mvnC-5n28B:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 10 TYR B 334
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.35A 5mvnD-5n28B:
undetectable		 5mvnD-5n28B:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 10 TYR B 334
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.42A 5mzrA-5n28B:
undetectable		 5mzrA-5n28B:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		5 / 10 ALA B 324
ILE B 208
ILE B 316
VAL C  73
ALA B 322
 None
 1.16A 5nukA-5n28B:
undetectable		 5nukA-5n28B:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A
HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C)		 5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus) 		4 / 4 GLU C 134
ARG C  46
ARG C  84
GLU C 130
 None
 1.25A 5odcB-5n28C:
0.0
5odcC-5n28C:
0.0
5odcG-5n28C:
0.0		 5odcB-5n28C:
20.73
5odcC-5n28C:
19.70
5odcG-5n28C:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(Methanotorris
formicicus;
Methanotorris
formicicus) 		4 / 5 HIS C 242
VAL A 372
LEU A 460
THR C 246
 None
 1.33A 5ohhA-5n28C:
undetectable		 5ohhA-5n28C:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 6 LEU A   9
PHE A   8
ASP A 343
HIS A 397
 None
None
None
MGN  A 402 ( 4.7A)
 1.08A 5om3A-5n28A:
undetectable
5om3B-5n28A:
undetectable		 5om3A-5n28A:
9.24
5om3B-5n28A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		3 / 3 TYR B 306
ALA B 248
TYR B 243
 None
 0.86A 5uunB-5n28B:
undetectable		 5uunB-5n28B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 11 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
 None
 1.13A 5x6yA-5n28B:
undetectable		 5x6yA-5n28B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 10 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
 None
 1.21A 5x6yB-5n28B:
undetectable		 5x6yB-5n28B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 11 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
 None
 1.17A 5x6yC-5n28B:
undetectable		 5x6yC-5n28B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 6 GLY A 428
SER A 414
THR A 419
VAL A 372
 TRX  A 429 ( 2.4A)
None
None
None
 1.22A 5ysiA-5n28A:
undetectable		 5ysiA-5n28A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 ALA B 329
GLY B 374
GLY B 372
VAL B 394
ASP B 401
 None
 1.17A 6clxA-5n28B:
undetectable		 6clxA-5n28B:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		5 / 12 LEU B 246
GLY B 436
ALA B 437
ILE B 444
ILE B  27
 None
 0.89A 6difB-5n28B:
undetectable		 6difB-5n28B:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(Methanotorris
formicicus) 		3 / 3 ALA B 305
PHE B 389
GLN B 220
 None
 0.85A 6eceA-5n28B:
undetectable		 6eceA-5n28B:
21.81