SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n29'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 10 VAL A 493
PHE A 388
VAL A 344
VAL A 418
VAL A 546
 None
None
None
8JB  A 419 ( 3.0A)
None
 1.27A 1fe2A-5n29A:
undetectable		 1fe2A-5n29A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 12 PHE A 566
PRO A 390
VAL A 344
LEU A 345
ILE A 361
 None
 1.31A 2xrlA-5n29A:
undetectable		 2xrlA-5n29A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 5 VAL A 474
VAL A 494
THR A 562
THR A 522
 None
 1.16A 3bjwG-5n29A:
undetectable		 3bjwG-5n29A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 5 VAL A 474
VAL A 494
THR A 562
THR A 522
 None
 1.19A 3bjwC-5n29A:
undetectable		 3bjwC-5n29A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 10 GLY A 400
CYH A 384
PHE A 348
GLY A 331
PHE A 329
 None
None
None
CL  A 602 (-3.6A)
None
 1.24A 3ko0R-5n29A:
undetectable
3ko0T-5n29A:
undetectable		 3ko0R-5n29A:
17.16
3ko0T-5n29A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 SER A 519
VAL A 477
PHE A 508
GLU A 478
 None
 1.37A 3n5tA-5n29A:
undetectable
3n5tB-5n29A:
undetectable		 3n5tA-5n29A:
21.40
3n5tB-5n29A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		3 / 3 VAL A 424
VAL A 330
SER A 366
 None
None
CL  A 602 (-3.3A)
 0.72A 3n8xB-5n29A:
undetectable		 3n8xB-5n29A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 12 TYR A 487
SER A 565
PHE A 548
VAL A 418
ALA A 534
 None
None
None
8JB  A 419 ( 3.0A)
None
 1.46A 3nhxA-5n29A:
undetectable		 3nhxA-5n29A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 12 ILE A 361
PHE A 329
TYR A 363
LEU A 359
ALA A 560
 None
 1.18A 3ozuA-5n29A:
undetectable		 3ozuA-5n29A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 PHE A 508
GLU A 478
SER A 519
VAL A 477
 None
 1.41A 4k5jA-5n29A:
undetectable
4k5jB-5n29A:
undetectable		 4k5jA-5n29A:
21.63
4k5jB-5n29A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 11 GLY A 391
GLY A 392
LEU A 420
HIS A 499
HIS A 549
 8JB  A 419 ( 3.4A)
8JB  A 419 ( 4.1A)
8JB  A 419 ( 4.6A)
None
8JB  A 419 ( 4.0A)
 0.64A 4l8fB-5n29A:
18.1		 4l8fB-5n29A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 11 GLY A 391
GLY A 392
LEU A 420
HIS A 499
HIS A 549
 8JB  A 419 ( 3.4A)
8JB  A 419 ( 4.1A)
8JB  A 419 ( 4.6A)
None
8JB  A 419 ( 4.0A)
 0.64A 4l8fD-5n29A:
18.2		 4l8fD-5n29A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		3 / 3 GLU A 370
ILE A 427
ALA A 404
 None
 0.66A 4wnwB-5n29A:
undetectable		 4wnwB-5n29A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 PHE A 508
GLU A 478
SER A 519
VAL A 477
 None
 1.38A 5adlA-5n29A:
undetectable
5adlB-5n29A:
undetectable		 5adlA-5n29A:
21.63
5adlB-5n29A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 8 ILE A 492
VAL A 493
GLN A 583
CYH A 581
 None
 1.19A 5dqyA-5n29A:
0.6		 5dqyA-5n29A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 PHE A 508
GLU A 478
SER A 519
VAL A 477
 None
 1.39A 5fj3A-5n29A:
undetectable
5fj3B-5n29A:
undetectable		 5fj3A-5n29A:
21.63
5fj3B-5n29A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		3 / 3 LYS A 379
ASP A 375
ILE A 387
 None
 0.82A 5kc4E-5n29A:
undetectable		 5kc4E-5n29A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 PHE A 508
GLU A 478
SER A 519
VAL A 477
 None
 1.42A 5vv7A-5n29A:
undetectable
5vv7B-5n29A:
undetectable		 5vv7A-5n29A:
21.63
5vv7B-5n29A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 PHE A 508
GLU A 478
SER A 519
VAL A 477
 None
 1.38A 5vvnA-5n29A:
undetectable
5vvnB-5n29A:
undetectable		 5vvnA-5n29A:
21.63
5vvnB-5n29A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 12 ALA A 425
VAL A 389
PHE A 543
LEU A 540
ARG A 431
 None
 1.17A 5w7pA-5n29A:
undetectable		 5w7pA-5n29A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		5 / 10 PHE A 329
ILE A 361
GLY A 386
MET A 567
ALA A 568
 None
 1.44A 5x66D-5n29A:
undetectable		 5x66D-5n29A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 SER A 519
VAL A 477
PHE A 508
GLU A 478
 None
 1.43A 6av6A-5n29A:
undetectable
6av6B-5n29A:
undetectable		 6av6A-5n29A:
15.45
6av6B-5n29A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 PHE A 508
GLU A 478
SER A 519
VAL A 477
 None
 1.43A 6av6C-5n29A:
undetectable
6av6D-5n29A:
undetectable		 6av6C-5n29A:
15.45
6av6D-5n29A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n29 CTP SYNTHASE
(Trypanosoma
brucei) 		4 / 7 SER A 519
VAL A 477
PHE A 508
GLU A 478
 None
 1.46A 6av7A-5n29A:
undetectable
6av7B-5n29A:
undetectable		 6av7A-5n29A:
15.45
6av7B-5n29A:
15.45