SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		4 / 8 GLY A  76
ILE A  47
SER A  21
GLU A  45
 None
 0.91A 1mrjA-5n2iA:
undetectable		 1mrjA-5n2iA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		4 / 8 ILE A  22
SER A  21
ASP A  82
LEU A 186
 None
 0.86A 2cdqA-5n2iA:
undetectable		 2cdqA-5n2iA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 11 ALA A  77
LEU A 141
LEU A  97
LEU A  25
LEU A 104
 None
 1.10A 2ceoA-5n2iA:
undetectable		 2ceoA-5n2iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 10 ALA A  77
LEU A 141
LEU A  97
LEU A  25
LEU A 104
 None
 1.16A 2riwA-5n2iA:
undetectable
2riwB-5n2iA:
undetectable		 2riwA-5n2iA:
21.61
2riwB-5n2iA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 10 ALA A  77
LEU A 141
LEU A  97
LEU A  25
LEU A 104
 None
 1.08A 2xn6A-5n2iA:
undetectable
2xn6B-5n2iA:
undetectable		 2xn6A-5n2iA:
22.22
2xn6B-5n2iA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 10 ALA A  77
LEU A 141
LEU A  97
LEU A  25
LEU A 104
 None
 1.07A 2xn7A-5n2iA:
undetectable
2xn7B-5n2iA:
undetectable		 2xn7A-5n2iA:
22.22
2xn7B-5n2iA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		4 / 6 VAL A 183
GLY A  32
ARG A  37
LEU A  63
 None
 1.07A 3bjwE-5n2iA:
undetectable		 3bjwE-5n2iA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 11 GLY A  49
GLY A  27
GLY A  32
ALA A  56
LEU A  48
 None
 1.07A 4l8fB-5n2iA:
2.8		 4l8fB-5n2iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 11 GLY A  49
GLY A  27
GLY A  32
ALA A  56
LEU A  48
 None
 1.08A 4l8fD-5n2iA:
3.0		 4l8fD-5n2iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 9 ALA A  78
ASP A  73
GLY A  49
LEU A  25
LEU A 104
 None
 1.17A 5dqfA-5n2iA:
undetectable		 5dqfA-5n2iA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		4 / 8 SER A 132
ALA A 133
LEU A 201
LEU A 173
 None
 1.09A 5dzkF-5n2iA:
undetectable
5dzkT-5n2iA:
undetectable		 5dzkF-5n2iA:
21.65
5dzkT-5n2iA:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		4 / 5 ASP A  91
PRO A 127
GLU A 129
ARG A  94
 None
 1.49A 5uxcA-5n2iA:
undetectable		 5uxcA-5n2iA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 12 VAL A 147
ILE A 190
VAL A 193
VAL A 183
HIS A 151
 None
 1.22A 6ap6A-5n2iA:
undetectable		 6ap6A-5n2iA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE
(Thermobifida
fusca) 		5 / 12 VAL A 147
ILE A 190
VAL A 193
VAL A 183
HIS A 151
 None
 1.22A 6ap6B-5n2iA:
undetectable		 6ap6B-5n2iA:
24.40