SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.19A 1zzrA-5n2kG:
undetectable
1zzrB-5n2kG:
undetectable		 1zzrA-5n2kG:
12.07
1zzrB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU G  84
VAL G 110
ARG G  62
VAL G  18
 None
 1.19A 1zzrA-5n2kG:
undetectable
1zzrB-5n2kG:
undetectable		 1zzrA-5n2kG:
12.07
1zzrB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.18A 1zzuA-5n2kG:
undetectable
1zzuB-5n2kG:
undetectable		 1zzuA-5n2kG:
12.07
1zzuB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU G  84
VAL G 110
ARG G  62
VAL G  18
 None
 1.19A 1zzuA-5n2kG:
undetectable
1zzuB-5n2kG:
undetectable		 1zzuA-5n2kG:
12.07
1zzuB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		5 / 12 TYR G  87
LEU G  48
VAL G  18
ALA G  81
VAL G 108
 None
 1.42A 2g70B-5n2kG:
undetectable		 2g70B-5n2kG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		5 / 12 TYR G  87
LEU G  48
VAL G  18
ALA G  81
VAL G 108
 None
 1.39A 2g72A-5n2kG:
undetectable		 2g72A-5n2kG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ASP G  86
LYS G 107
PRO G   7
GLY G 103
LEU G   4
 None
 1.31A 2nv4A-5n2kG:
undetectable		 2nv4A-5n2kG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.22A 3dqrA-5n2kG:
undetectable
3dqrB-5n2kG:
undetectable		 3dqrA-5n2kG:
12.07
3dqrB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 4 PRO G 169
THR G 168
GLY G  42
THR G  43
 None
 1.05A 3ib1A-5n2kG:
undetectable		 3ib1A-5n2kG:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.14A 3jx2A-5n2kG:
undetectable
3jx2B-5n2kG:
undetectable		 3jx2A-5n2kG:
12.07
3jx2B-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.19A 3jx3A-5n2kG:
undetectable
3jx3B-5n2kG:
undetectable		 3jx3A-5n2kG:
12.07
3jx3B-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.17A 3jx5A-5n2kG:
undetectable
3jx5B-5n2kG:
undetectable		 3jx5A-5n2kG:
12.07
3jx5B-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.12A 3jx6A-5n2kG:
undetectable
3jx6B-5n2kG:
undetectable		 3jx6A-5n2kG:
11.81
3jx6B-5n2kG:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.12A 3nljA-5n2kG:
undetectable
3nljB-5n2kG:
undetectable		 3nljA-5n2kG:
11.81
3nljB-5n2kG:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.15A 3nlpA-5n2kG:
undetectable
3nlpB-5n2kG:
undetectable		 3nlpA-5n2kG:
12.07
3nlpB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.13A 3nlqA-5n2kG:
undetectable
3nlqB-5n2kG:
undetectable		 3nlqA-5n2kG:
12.07
3nlqB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.16A 3nlrA-5n2kG:
undetectable
3nlrB-5n2kG:
undetectable		 3nlrA-5n2kG:
12.07
3nlrB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.20A 4cx3A-5n2kG:
undetectable
4cx3B-5n2kG:
undetectable		 4cx3A-5n2kG:
12.07
4cx3B-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU G  84
VAL G 110
ARG G  62
VAL G  18
 None
 1.18A 4cx3A-5n2kG:
undetectable
4cx3B-5n2kG:
undetectable		 4cx3A-5n2kG:
12.07
4cx3B-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.20A 4cx4A-5n2kG:
undetectable
4cx4B-5n2kG:
undetectable		 4cx4A-5n2kG:
12.07
4cx4B-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5n2k BRIAKINUMAB FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.21A 5g0pA-5n2kG:
undetectable
5g0pB-5n2kG:
undetectable		 5g0pA-5n2kG:
12.07
5g0pB-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.83A 5jsdA-5n2kB:
2.8		 5jsdA-5n2kB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.83A 5jsdB-5n2kB:
undetectable		 5jsdB-5n2kB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.82A 5jsdC-5n2kB:
undetectable		 5jsdC-5n2kB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.84A 5jseA-5n2kB:
2.4		 5jseA-5n2kB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.84A 5jseB-5n2kB:
undetectable		 5jseB-5n2kB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR B  28
SER B  31
TYR B  32
 None
 0.84A 5jseC-5n2kB:
2.9		 5jseC-5n2kB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 HIS B 102
HIS B  35
LEU B  45
VAL B  37
 None
 1.06A 6bc9A-5n2kB:
undetectable		 6bc9A-5n2kB:
15.48