SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 10 GLY A 189
VAL A   5
ALA A 201
ALA A 206
ILE A 175
 None
 1.11A 1likA-5n2pA:
undetectable		 1likA-5n2pA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		4 / 5 TRP A  62
PRO A  63
LEU A  59
GLY A  58
 None
 1.42A 1ya4C-5n2pA:
undetectable		 1ya4C-5n2pA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 10 LEU A  64
ASP A  67
ASP A  71
GLN A  16
ASP A  20
 None
 1.36A 2q58A-5n2pA:
undetectable		 2q58A-5n2pA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A  35
ARG A  69
LEU A   4
VAL A 231
VAL A  74
 None
 1.27A 2qd4B-5n2pA:
undetectable		 2qd4B-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		6 / 10 GLY A 205
ALA A 204
ASP A 200
VAL A 171
ILE A 187
ILE A 175
 None
 1.43A 3ekpD-5n2pA:
undetectable		 3ekpD-5n2pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		6 / 11 GLY A 205
ALA A 204
ASP A 200
VAL A 171
ILE A 187
ILE A 175
 None
 1.49A 3ektC-5n2pA:
undetectable		 3ektC-5n2pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 11 GLY A 205
ALA A 206
ASP A 207
LEU A 181
VAL A 159
 None
None
None
None
CL  A 303 ( 4.4A)
 0.88A 3em4U-5n2pA:
undetectable		 3em4U-5n2pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 12 ASN A 131
VAL A 132
TYR A 156
PHE A 154
LEU A 155
 None
 1.50A 3megA-5n2pA:
1.5		 3megA-5n2pA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A 238
TYR A 241
ALA A 201
GLY A 205
GLY A 208
 None
 0.96A 3ou6A-5n2pA:
undetectable		 3ou6A-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A 238
TYR A 241
ALA A 201
GLY A 205
GLY A 208
 None
 0.94A 3ou6B-5n2pA:
undetectable		 3ou6B-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A 238
TYR A 241
ALA A 201
GLY A 205
GLY A 208
 None
 0.98A 3ou7A-5n2pA:
undetectable		 3ou7A-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A 238
TYR A 241
ALA A 201
GLY A 205
GLY A 208
 None
 0.96A 3ou7D-5n2pA:
undetectable		 3ou7D-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		4 / 7 SER A 193
ASP A 197
GLY A 189
SER A 194
 None
 0.87A 4ac9C-5n2pA:
3.8		 4ac9C-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		4 / 5 THR A   9
GLY A  11
VAL A  15
PRO A  13
 None
 1.16A 4grkA-5n2pA:
undetectable		 4grkA-5n2pA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		6 / 10 GLY A 205
ALA A 204
ASP A 200
VAL A 171
ILE A 187
ILE A 175
 None
 1.44A 4ll3B-5n2pA:
undetectable		 4ll3B-5n2pA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		6 / 10 GLY A 205
ALA A 204
ASP A 200
VAL A 171
ILE A 187
ILE A 175
 None
 1.48A 4ll3A-5n2pA:
undetectable		 4ll3A-5n2pA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 10 GLY A 189
VAL A 188
THR A 135
VAL A 159
LEU A 155
 None
None
None
CL  A 303 ( 4.4A)
None
 1.18A 4yb6A-5n2pA:
undetectable
4yb6E-5n2pA:
undetectable		 4yb6A-5n2pA:
undetectable
4yb6E-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 10 GLY A 189
VAL A 188
THR A 135
VAL A 159
LEU A 155
 None
None
None
CL  A 303 ( 4.4A)
None
 1.19A 4yb6B-5n2pA:
undetectable
4yb6C-5n2pA:
undetectable		 4yb6B-5n2pA:
undetectable
4yb6C-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 10 LEU A 155
GLY A 189
VAL A 188
THR A 135
VAL A 159
 None
None
None
None
CL  A 303 ( 4.4A)
 1.24A 4yb6D-5n2pA:
undetectable
4yb6E-5n2pA:
undetectable		 4yb6D-5n2pA:
undetectable
4yb6E-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		5 / 10 LEU A 155
GLY A 189
VAL A 188
THR A 135
VAL A 159
 None
None
None
None
CL  A 303 ( 4.4A)
 1.17A 4yb6B-5n2pA:
undetectable
4yb6F-5n2pA:
undetectable		 4yb6B-5n2pA:
undetectable
4yb6F-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		4 / 8 GLY A 122
ILE A 123
LYS A 125
ASP A 152
 None
 0.94A 6ag0C-5n2pA:
6.4		 6ag0C-5n2pA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		4 / 7 LEU A  64
ASP A  67
ASP A  71
GLN A  16
 None
 1.22A 6g31D-5n2pA:
undetectable		 6g31D-5n2pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Sulfolobus
solfataricus) 		4 / 6 LEU A  64
ASP A  67
ASP A  71
GLN A  16
 None
 1.24A 6g31J-5n2pA:
undetectable		 6g31J-5n2pA:
21.51