SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		3 / 3 GLN A 559
TYR A 260
ARG A   2
 GOL  A 814 (-3.6A)
None
None
 0.94A 1gtbA-5n4aA:
undetectable		 1gtbA-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 8 SER A 280
THR A 277
LEU A 274
TRP A  22
 None
 1.13A 1mxgA-5n4aA:
undetectable		 1mxgA-5n4aA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 4 SER A 555
SER A 571
LEU A 200
PHE A 221
 None
 1.39A 1r5lA-5n4aA:
undetectable		 1r5lA-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 7 VAL A 244
TYR A 162
CYH A 161
CYH A 253
 None
 1.15A 1t46A-5n4aA:
undetectable		 1t46A-5n4aA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 7 LYS A   4
LEU A   3
GLN A 296
LEU A 250
 None
 1.10A 1v55C-5n4aA:
undetectable
1v55J-5n4aA:
undetectable		 1v55C-5n4aA:
undetectable
1v55J-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A 173
ILE A 130
LEU A 119
SER A 132
 None
 0.95A 2byoA-5n4aA:
undetectable		 2byoA-5n4aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 7 LYS A   4
LEU A   3
GLN A 296
LEU A 250
 None
 1.05A 2dysP-5n4aA:
undetectable
2dysW-5n4aA:
undetectable		 2dysP-5n4aA:
undetectable
2dysW-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 204
SER A 223
GLY A 285
LEU A 274
LEU A 283
 None
 0.85A 2hw2A-5n4aA:
undetectable		 2hw2A-5n4aA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 8 LEU A 347
LEU A 330
ASP A 328
ASP A 321
 None
 0.91A 2j2pA-5n4aA:
undetectable
2j2pB-5n4aA:
undetectable		 2j2pA-5n4aA:
15.89
2j2pB-5n4aA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 10 ILE A 263
LEU A 265
VAL A 293
GLY A 285
GLY A 295
 None
 1.26A 2wd9C-5n4aA:
undetectable		 2wd9C-5n4aA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		3 / 3 TYR A 114
ASP A 193
HIS A 199
 GOL  A 802 ( 4.4A)
None
GOL  A 802 (-3.7A)
 0.97A 3e23A-5n4aA:
undetectable		 3e23A-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		3 / 3 ASN A 484
ASP A 505
GLN A 522
 GOL  A 809 (-3.8A)
None
GOL  A 810 (-2.9A)
 0.73A 3eeyC-5n4aA:
undetectable		 3eeyC-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		3 / 3 ASN A 484
ASP A 505
GLN A 522
 GOL  A 809 (-3.8A)
None
GOL  A 810 (-2.9A)
 0.72A 3eeyD-5n4aA:
undetectable		 3eeyD-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		3 / 3 ASN A 484
ASP A 505
GLN A 522
 GOL  A 809 (-3.8A)
None
GOL  A 810 (-2.9A)
 0.73A 3eeyE-5n4aA:
undetectable		 3eeyE-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 10 VAL A 189
GLY A 187
VAL A 169
GLN A 179
GLY A 165
 None
 1.32A 3km6A-5n4aA:
undetectable		 3km6A-5n4aA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A 396
PHE A 385
ALA A 447
THR A 446
ILE A 429
 None
 1.16A 3ndiA-5n4aA:
undetectable		 3ndiA-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 384
LEU A 379
ILE A 394
PRO A 407
LEU A 377
 None
 0.99A 3nrrB-5n4aA:
undetectable		 3nrrB-5n4aA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 SER A 270
GLY A 204
GLY A 245
GLY A 246
VAL A 188
 GOL  A 805 (-3.7A)
None
None
None
GOL  A 806 ( 4.8A)
 0.85A 4b17A-5n4aA:
undetectable		 4b17A-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 7 ARG A 402
GLY A 401
GLU A 400
GLN A 395
 None
GOL  A 808 (-4.0A)
GOL  A 811 ( 3.5A)
None
 1.02A 4g0vA-5n4aA:
undetectable		 4g0vA-5n4aA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 8 THR A 428
ALA A 430
LEU A 432
THR A 423
 None
 0.77A 4ik7B-5n4aA:
undetectable		 4ik7B-5n4aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 371
LEU A 388
GLY A 393
ALA A 392
SER A 391
 None
None
GOL  A 807 ( 4.7A)
None
None
 1.02A 4otyA-5n4aA:
undetectable		 4otyA-5n4aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 371
LEU A 388
GLY A 393
ALA A 392
SER A 391
 None
None
GOL  A 807 ( 4.7A)
None
None
 1.04A 4otyB-5n4aA:
undetectable		 4otyB-5n4aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 7 THR A 428
ALA A 430
LEU A 432
THR A 423
 None
 0.69A 4pwjB-5n4aA:
undetectable		 4pwjB-5n4aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 371
LEU A 388
GLY A 393
ALA A 392
SER A 391
 None
None
GOL  A 807 ( 4.7A)
None
None
 1.00A 4rrwD-5n4aA:
undetectable		 4rrwD-5n4aA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 371
LEU A 388
GLY A 393
ALA A 392
SER A 391
 None
None
GOL  A 807 ( 4.7A)
None
None
 1.00A 4rrzD-5n4aA:
undetectable		 4rrzD-5n4aA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 7 THR A 428
ALA A 430
LEU A 432
THR A 423
 None
 0.55A 5bojB-5n4aA:
undetectable		 5bojB-5n4aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 PRO A 366
LEU A 347
LEU A 363
VAL A 319
PHE A 333
 None
 1.07A 5im2A-5n4aA:
undetectable		 5im2A-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 VAL A 311
PRO A 366
LEU A 347
LEU A 363
PHE A 333
 None
 1.07A 5im2A-5n4aA:
undetectable		 5im2A-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 5 VAL A 319
THR A 360
ASP A 304
LEU A 342
 None
None
GOL  A 804 (-2.0A)
None
 1.28A 5m0iB-5n4aA:
undetectable		 5m0iB-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 110
HIS A  61
VAL A 189
VAL A 192
ASP A 193
 None
 1.31A 6bxlB-5n4aA:
undetectable		 6bxlB-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80
(Chlamydomonas
reinhardtii) 		4 / 5 ASP A 313
ARG A 316
GLN A 296
LYS A   4
 None
 1.49A 6g31C-5n4aA:
undetectable		 6g31C-5n4aA:
16.85