SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 10 ALA A 523
PHE A 522
ALA A 556
LEU A 582
ILE A 527
 None
 1.29A 1claA-5n4cA:
undetectable		 1claA-5n4cA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 7 VAL A 463
VAL A 380
TYR A 496
ARG A 479
 None
 1.16A 1t46A-5n4cA:
undetectable		 1t46A-5n4cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 4 LYS A 702
LEU A 696
LEU A 164
SER A 142
 None
 1.46A 1tt6A-5n4cA:
undetectable		 1tt6A-5n4cA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 10 GLY A 569
GLY A 596
ILE A 521
LEU A 560
ALA A 566
 None
 1.12A 1x7pA-5n4cA:
2.0
1x7pB-5n4cA:
undetectable		 1x7pA-5n4cA:
18.42
1x7pB-5n4cA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 4 LEU A  57
SER A  60
TYR A  61
LEU A 688
 None
 1.13A 1xz1A-5n4cA:
undetectable		 1xz1A-5n4cA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 4 LEU A  57
SER A  60
TYR A  61
LEU A 688
 None
 1.12A 1xz3A-5n4cA:
undetectable		 1xz3A-5n4cA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 11 ALA A 598
ILE A 655
GLY A 580
PRO A 640
VAL A 588
ILE A 587
 None
 1.39A 2aquB-5n4cA:
undetectable		 2aquB-5n4cA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 12 GLY A 529
GLY A 497
ALA A 500
THR A 501
GLU A 535
 None
 1.05A 2gluA-5n4cA:
undetectable		 2gluA-5n4cA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 5 SER A 211
LEU A  90
GLY A 154
ARG A 410
 None
 1.21A 2j2pA-5n4cA:
undetectable
2j2pB-5n4cA:
undetectable		 2j2pA-5n4cA:
17.05
2j2pB-5n4cA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 12 ILE A 587
GLY A 593
ALA A 597
ALA A 598
VAL A 599
 None
 0.98A 2oc8A-5n4cA:
undetectable		 2oc8A-5n4cA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 12 ALA A 598
ILE A 655
GLY A 580
PRO A 640
VAL A 588
ILE A 587
 None
 1.40A 2r5pB-5n4cA:
undetectable		 2r5pB-5n4cA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 12 ALA A 598
ILE A 655
GLY A 580
PRO A 640
VAL A 588
ILE A 587
 None
 1.40A 2r5pD-5n4cA:
undetectable		 2r5pD-5n4cA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 12 PHE A 132
THR A 170
VAL A 161
GLY A 144
GLN A 106
 None
 1.27A 2ve3B-5n4cA:
undetectable		 2ve3B-5n4cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 11 ALA A 598
ILE A 655
GLY A 580
PRO A 640
VAL A 588
ILE A 587
 None
 1.36A 3em4U-5n4cA:
undetectable		 3em4U-5n4cA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 11 GLY A 529
GLY A 497
PHE A 553
ALA A 500
THR A 501
GLU A 535
 None
 1.23A 3g88A-5n4cA:
undetectable		 3g88A-5n4cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 11 GLY A 529
GLY A 497
PHE A 553
ALA A 500
THR A 501
GLU A 535
 None
 1.24A 3g88B-5n4cA:
undetectable		 3g88B-5n4cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 12 GLY A 529
GLY A 497
PHE A 553
ALA A 500
THR A 501
GLU A 535
 None
 1.21A 3g89A-5n4cA:
undetectable		 3g89A-5n4cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 11 GLY A 529
GLY A 497
PHE A 553
ALA A 500
GLU A 535
 None
 1.07A 3g89B-5n4cA:
undetectable		 3g89B-5n4cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 11 GLY A 529
GLY A 497
PHE A 553
ALA A 500
THR A 501
 None
 1.01A 3g89B-5n4cA:
undetectable		 3g89B-5n4cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 12 GLY A 529
GLY A 497
PHE A 553
ALA A 500
THR A 501
GLU A 535
 None
 1.17A 3g8bA-5n4cA:
undetectable		 3g8bA-5n4cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 12 GLY A 529
GLY A 497
PHE A 553
ALA A 500
THR A 501
GLU A 535
 None
 1.24A 3g8bB-5n4cA:
undetectable		 3g8bB-5n4cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 7 TYR A 314
GLU A 309
LYS A 336
ASN A 331
 None
 1.22A 3k8mA-5n4cA:
undetectable		 3k8mA-5n4cA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		6 / 9 ALA A 598
ILE A 655
GLY A 580
PRO A 640
VAL A 588
ILE A 587
 None
 1.39A 3nuoA-5n4cA:
undetectable		 3nuoA-5n4cA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 6 LEU A  57
SER A  60
TYR A  61
LEU A 688
 None
 1.13A 3rd0A-5n4cA:
undetectable		 3rd0A-5n4cA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 11 ALA A 711
GLY A 716
ILE A 718
ILE A 511
ILE A 510
 None
 0.91A 3s45B-5n4cA:
undetectable		 3s45B-5n4cA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 7 ILE A 587
LYS A 546
PHE A 553
GLY A 495
 None
 1.14A 3sj0X-5n4cA:
undetectable		 3sj0X-5n4cA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 12 GLU A 532
GLY A 497
GLY A 495
ALA A 503
GLY A 530
 None
 1.12A 3tegA-5n4cA:
undetectable		 3tegA-5n4cA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 8 GLY A 495
ALA A 576
TYR A 494
GLU A 601
 None
 0.85A 3u9hA-5n4cA:
undetectable		 3u9hA-5n4cA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 8 GLY A 495
ALA A 576
TYR A 494
GLU A 601
 None
 0.87A 3u9hB-5n4cA:
undetectable		 3u9hB-5n4cA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		3 / 3 GLU A 291
TYR A 272
SER A 322
 None
 0.97A 4at0A-5n4cA:
undetectable		 4at0A-5n4cA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 8 GLY A 495
ALA A 576
TYR A 494
GLU A 601
 None
 0.85A 4bjcA-5n4cA:
undetectable		 4bjcA-5n4cA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 9 GLY A 602
GLY A 603
MET A 584
PHE A 670
ILE A 689
 None
 1.33A 4fgjA-5n4cA:
1.7
4fgjB-5n4cA:
1.7		 4fgjA-5n4cA:
15.33
4fgjB-5n4cA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 11 PHE A 670
ILE A 689
GLY A 602
GLY A 603
MET A 584
 None
 1.34A 4fglA-5n4cA:
2.3
4fglB-5n4cA:
2.2		 4fglA-5n4cA:
15.33
4fglB-5n4cA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 8 GLY A 497
THR A 549
MET A 584
GLY A 585
 None
 0.82A 4fo4B-5n4cA:
undetectable		 4fo4B-5n4cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 7 LYS A 198
TYR A 172
TYR A 159
PHE A 150
 None
 1.26A 4yv5B-5n4cA:
undetectable		 4yv5B-5n4cA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 7 ALA A 557
GLY A 575
THR A 656
GLU A 601
 None
 0.96A 5bs8A-5n4cA:
undetectable
5bs8B-5n4cA:
2.8
5bs8C-5n4cA:
undetectable		 5bs8A-5n4cA:
21.75
5bs8B-5n4cA:
16.76
5bs8C-5n4cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 6 ALA A 557
GLY A 575
THR A 656
GLU A 601
 None
 0.94A 5btgA-5n4cA:
undetectable
5btgB-5n4cA:
2.2
5btgC-5n4cA:
undetectable		 5btgA-5n4cA:
21.75
5btgB-5n4cA:
16.76
5btgC-5n4cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 12 GLY A 498
ILE A 527
GLY A 495
GLY A 603
PHE A 550
 None
 1.03A 5d4uA-5n4cA:
undetectable		 5d4uA-5n4cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 12 GLY A 498
ILE A 527
GLY A 495
GLY A 603
PHE A 550
 None
 1.01A 5d4uB-5n4cA:
undetectable		 5d4uB-5n4cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 4 VAL A 307
ALA A 312
ILE A 326
THR A 328
 None
 1.18A 5e4dB-5n4cA:
undetectable		 5e4dB-5n4cA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		3 / 3 TYR A 310
TYR A 262
GLN A 277
 None
 1.17A 5jsdA-5n4cA:
1.1
5jsdB-5n4cA:
0.4		 5jsdA-5n4cA:
23.31
5jsdB-5n4cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		3 / 3 TYR A 310
TYR A 262
GLN A 277
 None
 1.16A 5jsdB-5n4cA:
0.4
5jsdC-5n4cA:
0.8		 5jsdB-5n4cA:
23.31
5jsdC-5n4cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 9 ALA A 598
ILE A 655
GLY A 580
PRO A 640
ILE A 587
 None
 1.12A 5kr0A-5n4cA:
undetectable		 5kr0A-5n4cA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		5 / 10 GLY A 602
GLY A 603
MET A 584
PHE A 670
ILE A 689
 None
 1.43A 5lbtA-5n4cA:
undetectable
5lbtB-5n4cA:
2.3		 5lbtA-5n4cA:
15.34
5lbtB-5n4cA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 5 TYR A 623
VAL A 604
ASP A 606
ALA A 605
 None
 1.10A 5otrA-5n4cA:
undetectable		 5otrA-5n4cA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 6 TRP A  97
PHE A 120
ARG A 431
TRP A  95
 None
 1.42A 5uocA-5n4cA:
0.0
5uocB-5n4cA:
0.0		 5uocA-5n4cA:
21.05
5uocB-5n4cA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 5n4c PROLYL
OLIGOPEPTIDASE
(Galerina
marginata) 		4 / 4 MET A 700
GLY A 699
HIS A 698
GLY A 697
 None
 0.86A 6fgdA-5n4cA:
3.7		 6fgdA-5n4cA:
19.64