SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)
5n4g HEAVY CHAIN
(Homo
sapiens)
4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
None
1.11A 1lqtB-5n4gH:
undetectable
1lqtB-5n4gH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)
5n4g HEAVY CHAIN
(Homo
sapiens)
4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
None
1.14A 1lquB-5n4gH:
undetectable
1lquB-5n4gH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)
5n4g HEAVY CHAIN
(Homo
sapiens)
4 / 6 LEU H 126
ALA H 139
SER H 129
SER H 130
None
1.02A 1tz8C-5n4gH:
4.1
1tz8D-5n4gH:
undetectable
1tz8C-5n4gH:
21.24
1tz8D-5n4gH:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 VAL H 165
VAL H 184
SER H 182
ASN H 199
ASN H 157
None
1.45A 2y03A-5n4gH:
undetectable
2y03A-5n4gH:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5n4g HEAVY CHAIN
(Homo
sapiens)
4 / 7 ARG H  98
VAL H   2
TYR H  27
GLN H   1
EDO  H 302 (-3.5A)
None
None
None
0.91A 3hgxA-5n4gH:
undetectable
3hgxA-5n4gH:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
5n4g HEAVY CHAIN
(Homo
sapiens)
4 / 8 ILE H  51
ALA H  53
THR H  74
ALA H  24
None
0.95A 3hrdA-5n4gH:
undetectable
3hrdB-5n4gH:
undetectable
3hrdA-5n4gH:
20.00
3hrdB-5n4gH:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5n4g HEAVY CHAIN
(Homo
sapiens)
4 / 8 ARG H  98
VAL H   2
TYR H  27
GLN H   1
EDO  H 302 (-3.5A)
None
None
None
0.93A 3remA-5n4gH:
undetectable
3remA-5n4gH:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5n4g HEAVY CHAIN
(Homo
sapiens)
4 / 8 ARG H  98
VAL H   2
TYR H  27
GLN H   1
EDO  H 302 (-3.5A)
None
None
None
0.96A 3remB-5n4gH:
undetectable
3remB-5n4gH:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.82A 4qvnH-5n4gH:
undetectable
4qvnI-5n4gH:
undetectable
4qvnH-5n4gH:
23.64
4qvnI-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 10 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.82A 4qvnV-5n4gH:
undetectable
4qvnW-5n4gH:
undetectable
4qvnV-5n4gH:
23.64
4qvnW-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.79A 4qvpH-5n4gH:
undetectable
4qvpI-5n4gH:
undetectable
4qvpH-5n4gH:
23.64
4qvpI-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.80A 4qvpV-5n4gH:
undetectable
4qvpW-5n4gH:
undetectable
4qvpV-5n4gH:
23.64
4qvpW-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.81A 4qvqH-5n4gH:
undetectable
4qvqI-5n4gH:
undetectable
4qvqH-5n4gH:
23.64
4qvqI-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.80A 4qvqV-5n4gH:
undetectable
4qvqW-5n4gH:
undetectable
4qvqV-5n4gH:
23.64
4qvqW-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.85A 4qvvH-5n4gH:
undetectable
4qvvH-5n4gH:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.85A 4qvvV-5n4gH:
undetectable
4qvvV-5n4gH:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.85A 4qvyH-5n4gH:
undetectable
4qvyH-5n4gH:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.85A 4qvyV-5n4gH:
undetectable
4qvyW-5n4gH:
undetectable
4qvyV-5n4gH:
23.64
4qvyW-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.84A 4qw0H-5n4gH:
undetectable
4qw0I-5n4gH:
undetectable
4qw0H-5n4gH:
23.64
4qw0I-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.84A 4qw0V-5n4gH:
undetectable
4qw0W-5n4gH:
undetectable
4qw0V-5n4gH:
23.64
4qw0W-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.84A 4qw1H-5n4gH:
undetectable
4qw1I-5n4gH:
undetectable
4qw1H-5n4gH:
23.64
4qw1I-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.84A 4qw1V-5n4gH:
undetectable
4qw1W-5n4gH:
undetectable
4qw1V-5n4gH:
23.64
4qw1W-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.85A 4qwuH-5n4gH:
undetectable
4qwuI-5n4gH:
undetectable
4qwuH-5n4gH:
23.64
4qwuI-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.85A 4qwuV-5n4gH:
undetectable
4qwuW-5n4gH:
undetectable
4qwuV-5n4gH:
23.64
4qwuW-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)
5n4g HEAVY CHAIN
(Homo
sapiens)
3 / 3 LYS H 101
ARG H  98
HIS H  32
None
EDO  H 302 (-3.5A)
EDO  H 302 (-3.9A)
1.27A 4zbrA-5n4gH:
undetectable
4zbrA-5n4gH:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.85A 5bxnH-5n4gH:
undetectable
5bxnI-5n4gH:
undetectable
5bxnH-5n4gH:
23.64
5bxnI-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.83A 5cz7V-5n4gH:
undetectable
5cz7W-5n4gH:
undetectable
5cz7V-5n4gH:
23.64
5cz7W-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.83A 5d0xV-5n4gH:
undetectable
5d0xV-5n4gH:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.79A 5l5fH-5n4gH:
undetectable
5l5fI-5n4gH:
undetectable
5l5fH-5n4gH:
23.64
5l5fI-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.79A 5l5fV-5n4gH:
undetectable
5l5fW-5n4gH:
undetectable
5l5fV-5n4gH:
23.64
5l5fW-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.84A 5l66H-5n4gH:
undetectable
5l66I-5n4gH:
undetectable
5l66H-5n4gH:
23.64
5l66I-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5n4g HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER H 190
GLY H 136
THR H 137
ALA H 138
THR H 133
None
0.84A 5l66V-5n4gH:
undetectable
5l66W-5n4gH:
undetectable
5l66V-5n4gH:
23.64
5l66W-5n4gH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5n4g HEAVY CHAIN
(Homo
sapiens)
6 / 12 VAL H 186
THR H 137
LEU H 161
VAL H 165
GLY H 164
VAL H 213
None
1.49A 6a94B-5n4gH:
undetectable
6a94B-5n4gH:
19.00