SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 LEU A  53
GLU A  51
ALA A  48
LEU A  45
 None
 1.03A 1eta1-5n4wA:
undetectable		 1eta1-5n4wA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 LEU A  53
GLU A  51
ALA A  48
LEU A  45
 None
 1.01A 1eta2-5n4wA:
undetectable		 1eta2-5n4wA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 6 LEU A  53
GLU A  51
ALA A  48
LEU A  45
 None
 0.96A 1etb1-5n4wA:
undetectable		 1etb1-5n4wA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 5n4w CULLIN-2
(Homo
sapiens) 		5 / 10 GLY A 183
LEU A 144
PHE A 207
PHE A 188
TYR A 203
 None
 1.36A 1eveA-5n4wA:
undetectable		 1eveA-5n4wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 8 SER A 328
THR A 327
GLU A 289
LYS A 349
 None
 0.94A 1mxgA-5n4wA:
undetectable		 1mxgA-5n4wA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5n4w CULLIN-2
(Homo
sapiens) 		5 / 12 LEU A  77
VAL A  83
LEU A 155
PRO A 154
ILE A 158
 None
 1.00A 1zq9B-5n4wA:
undetectable		 1zq9B-5n4wA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 6 ILE A 319
LEU A 315
LEU A 372
ASP A 369
 None
 1.07A 2rlfA-5n4wA:
undetectable
2rlfD-5n4wA:
undetectable		 2rlfA-5n4wA:
5.13
2rlfD-5n4wA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5n4w CULLIN-2
(Homo
sapiens) 		3 / 3 MET A 480
GLU A 454
ASP A 396
 None
 0.74A 3a25A-5n4wA:
undetectable		 3a25A-5n4wA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5n4w CULLIN-2
(Homo
sapiens) 		3 / 3 VAL A 421
LYS A 423
HIS A 320
 None
 0.91A 3elzA-5n4wA:
undetectable		 3elzA-5n4wA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 MET A 539
PHE A 543
PHE A 490
PHE A 507
 None
 1.40A 3ko0F-5n4wA:
0.9
3ko0G-5n4wA:
0.9		 3ko0F-5n4wA:
10.48
3ko0G-5n4wA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 8 ILE A 425
GLN A 432
ALA A 392
LEU A 391
 None
 0.78A 3ozwA-5n4wA:
2.1		 3ozwA-5n4wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5n4w CULLIN-2
(Homo
sapiens) 		5 / 12 GLY A 140
ASN A 109
ALA A  98
ALA A 143
TYR A  94
 None
 1.20A 4pclA-5n4wA:
undetectable		 4pclA-5n4wA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.13A 5hm8A-5n4wA:
undetectable		 5hm8A-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.13A 5hm8B-5n4wA:
undetectable		 5hm8B-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.13A 5hm8C-5n4wA:
undetectable		 5hm8C-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.13A 5hm8D-5n4wA:
undetectable		 5hm8D-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.13A 5hm8E-5n4wA:
undetectable		 5hm8E-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.13A 5hm8F-5n4wA:
undetectable		 5hm8F-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.14A 5hm8G-5n4wA:
undetectable		 5hm8G-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 5 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.13A 5hm8H-5n4wA:
undetectable		 5hm8H-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5n4w CULLIN-2
(Homo
sapiens) 		4 / 6 ASP A 675
GLN A 432
LEU A 473
SER A 471
 None
 1.10A 6ekuA-5n4wA:
undetectable		 6ekuA-5n4wA:
21.90