SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		6 / 12 GLY A  65
PHE A  67
SER A  72
ALA A 118
ALA A 140
TYR A 148
 SAM  A 306 (-3.2A)
SAM  A 306 (-4.2A)
None
SAM  A 306 (-3.5A)
SAM  A 306 (-3.6A)
None
 0.83A 2avdA-5n5dA:
28.4		 2avdA-5n5dA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		7 / 12 GLY A  65
PHE A  67
TYR A  70
SER A  71
ALA A 118
ALA A 140
TYR A 148
 SAM  A 306 (-3.2A)
SAM  A 306 (-4.2A)
None
SAM  A 306 (-2.2A)
SAM  A 306 (-3.5A)
SAM  A 306 (-3.6A)
None
 0.62A 2avdA-5n5dA:
28.4		 2avdA-5n5dA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		7 / 12 GLY A  65
PHE A  67
TYR A  70
ALA A 118
ASP A 139
ALA A 140
TYR A 148
 SAM  A 306 (-3.2A)
SAM  A 306 (-4.2A)
None
SAM  A 306 (-3.5A)
SAM  A 306 (-2.3A)
SAM  A 306 (-3.6A)
None
 0.56A 2avdB-5n5dA:
28.0		 2avdB-5n5dA:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		3 / 3 GLY A  65
GLU A  89
ASP A 139
 SAM  A 306 (-3.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.12A 2b25B-5n5dA:
15.6		 2b25B-5n5dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 ILE A 145
THR A 216
LEU A 193
VAL A 220
PHE A 149
 None
 1.16A 2qo5A-5n5dA:
undetectable		 2qo5A-5n5dA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		3 / 3 SER A  71
GLU A  89
ASP A 139
 SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.25A 2zthA-5n5dA:
17.7		 2zthA-5n5dA:
29.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 6 GLY A  65
SER A  71
ILE A  88
GLU A  89
ASP A 139
 SAM  A 306 (-3.2A)
SAM  A 306 (-2.2A)
SAM  A 306 ( 4.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.26A 3a7eA-5n5dA:
22.8		 3a7eA-5n5dA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 GLN A  45
PHE A  13
THR A 209
GLY A  46
LEU A  51
 BU3  A 301 (-3.6A)
None
None
None
None
 1.36A 3aodC-5n5dA:
undetectable		 3aodC-5n5dA:
13.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		3 / 3 SER A  71
GLU A  89
ASP A 139
 SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.19A 3bwmA-5n5dA:
22.8		 3bwmA-5n5dA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		3 / 3 SER A  71
GLU A  89
ASP A 139
 SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.20A 3bwyA-5n5dA:
22.8		 3bwyA-5n5dA:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 5 PRO A 143
ILE A 145
PRO A 146
TYR A 148
 SO4  A 308 (-4.4A)
None
None
None
 1.39A 3d9lA-5n5dA:
undetectable
3d9lY-5n5dA:
undetectable		 3d9lA-5n5dA:
18.14
3d9lY-5n5dA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 11 GLU A  63
GLY A  65
ILE A  88
GLU A  89
ALA A 118
 SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
SAM  A 306 ( 4.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-3.5A)
 0.55A 3dxyA-5n5dA:
12.6		 3dxyA-5n5dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 11 GLY A  65
ILE A  88
GLU A  89
ALA A 118
ASP A 139
 SAM  A 306 (-3.2A)
SAM  A 306 ( 4.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-3.5A)
SAM  A 306 (-2.3A)
 0.57A 3nmuB-5n5dA:
undetectable
3nmuJ-5n5dA:
14.2		 3nmuB-5n5dA:
20.57
3nmuJ-5n5dA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 10 GLU A  63
GLY A  65
SER A  71
GLU A  89
ASP A 139
 SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.27A 3s68A-5n5dA:
19.0		 3s68A-5n5dA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 5 ILE A 145
VAL A 163
LEU A  49
ASP A 139
 None
BU3  A 301 ( 4.6A)
BU3  A 301 ( 3.7A)
SAM  A 306 (-2.3A)
 1.01A 3wzdA-5n5dA:
undetectable		 3wzdA-5n5dA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 5 SER A  71
GLU A  89
ASP A 139
ASN A 141
 SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
SAM  A 306 ( 2.9A)
 0.21A 4pclA-5n5dA:
29.6		 4pclA-5n5dA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		6 / 12 GLU A  63
GLY A  65
ALA A 118
ALA A 140
ASN A 141
TYR A 148
 SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
SAM  A 306 (-3.5A)
SAM  A 306 (-3.6A)
SAM  A 306 ( 2.9A)
None
 0.24A 4pclB-5n5dA:
29.4		 4pclB-5n5dA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 LEU A  49
GLU A  63
GLY A  65
ALA A 118
TYR A 148
 BU3  A 301 ( 3.7A)
SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
SAM  A 306 (-3.5A)
None
 1.33A 4pclB-5n5dA:
29.4		 4pclB-5n5dA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 4 ASN A 166
LEU A  49
PHE A  67
TYR A  70
 None
BU3  A 301 ( 3.7A)
SAM  A 306 (-4.2A)
None
 1.40A 4u14A-5n5dA:
undetectable		 4u14A-5n5dA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 VAL A  41
GLU A  63
GLY A  65
TYR A  70
ILE A  88
 SAM  A 306 (-3.4A)
SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
None
SAM  A 306 ( 4.2A)
 0.39A 4xucA-5n5dA:
22.8		 4xucA-5n5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 VAL A  41
GLU A  63
GLY A  65
TYR A  70
ILE A  88
 SAM  A 306 (-3.4A)
SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
None
SAM  A 306 ( 4.2A)
 0.41A 4xudA-5n5dA:
22.6		 4xudA-5n5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		3 / 3 SER A  71
GLU A  89
ASP A 139
 SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.18A 4xudA-5n5dA:
22.6		 4xudA-5n5dA:
29.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 5 GLY A  65
TYR A  70
SER A  71
GLU A  89
ASP A 139
 SAM  A 306 (-3.2A)
None
SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.49A 4xueA-5n5dA:
22.9		 4xueA-5n5dA:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		6 / 12 GLY A  65
TYR A  70
ALA A 118
ALA A 140
ASN A 141
TYR A 148
 SAM  A 306 (-3.2A)
None
SAM  A 306 (-3.5A)
SAM  A 306 (-3.6A)
SAM  A 306 ( 2.9A)
None
 0.36A 4ymgA-5n5dA:
24.8		 4ymgA-5n5dA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		6 / 12 GLY A  65
SER A  72
ALA A 118
ALA A 140
ASN A 141
TYR A 148
 SAM  A 306 (-3.2A)
None
SAM  A 306 (-3.5A)
SAM  A 306 (-3.6A)
SAM  A 306 ( 2.9A)
None
 0.88A 4ymgB-5n5dA:
25.0		 4ymgB-5n5dA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		8 / 12 GLY A  65
TYR A  70
SER A  71
ALA A 118
ASP A 139
ALA A 140
ASN A 141
TYR A 148
 SAM  A 306 (-3.2A)
None
SAM  A 306 (-2.2A)
SAM  A 306 (-3.5A)
SAM  A 306 (-2.3A)
SAM  A 306 (-3.6A)
SAM  A 306 ( 2.9A)
None
 0.37A 4ymgB-5n5dA:
25.0		 4ymgB-5n5dA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 VAL A 164
ALA A 152
LEU A  75
SER A  71
LEU A 119
 None
None
None
SAM  A 306 (-2.2A)
None
 1.07A 5hv1A-5n5dA:
undetectable		 5hv1A-5n5dA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 ILE A 145
PHE A 189
ALA A 140
ASP A 139
VAL A 136
 None
None
SAM  A 306 (-3.6A)
SAM  A 306 (-2.3A)
None
 0.90A 5jkvA-5n5dA:
undetectable		 5jkvA-5n5dA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 6 THR A  66
GLY A  65
GLU A  63
ILE A 145
 None
SAM  A 306 (-3.2A)
SAM  A 306 ( 3.6A)
None
 0.96A 5kmfA-5n5dA:
undetectable
5kmfC-5n5dA:
undetectable		 5kmfA-5n5dA:
20.21
5kmfC-5n5dA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		7 / 12 GLU A  63
GLY A  65
TYR A  70
ALA A 118
ASP A 139
ALA A 140
TYR A 148
 SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
None
SAM  A 306 (-3.5A)
SAM  A 306 (-2.3A)
SAM  A 306 (-3.6A)
None
 0.52A 5kvaA-5n5dA:
23.6		 5kvaA-5n5dA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		7 / 12 GLU A  63
GLY A  65
TYR A  70
ALA A 118
ASP A 139
ALA A 140
TYR A 148
 SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
None
SAM  A 306 (-3.5A)
SAM  A 306 (-2.3A)
SAM  A 306 (-3.6A)
None
 0.58A 5kvaB-5n5dA:
23.5		 5kvaB-5n5dA:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 4 TYR A  70
SER A  71
GLU A  89
ASP A 139
 None
SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.48A 5lsaA-5n5dA:
22.8		 5lsaA-5n5dA:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		12 / 12 ALA A  40
VAL A  41
GLU A  63
GLY A  65
TYR A  70
TRP A  90
GLU A  91
ARG A 117
ALA A 118
PHE A 137
ALA A 140
TYR A 148
 SAM  A 306 (-3.3A)
SAM  A 306 (-3.4A)
SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
None
None
None
None
SAM  A 306 (-3.5A)
BU3  A 301 (-4.1A)
SAM  A 306 (-3.6A)
None
 0.46A 5n5dA-5n5dA:
43.4		 5n5dA-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 7 LEU A  39
PHE A  67
SER A  71
ILE A  64
 SAM  A 306 (-3.5A)
SAM  A 306 (-4.2A)
SAM  A 306 (-2.2A)
None
 0.82A 5n5dA-5n5dA:
43.4		 5n5dA-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		7 / 7 LEU A  39
PHE A  67
SER A  71
ILE A  88
GLU A  89
ASP A 139
ASN A 141
 SAM  A 306 (-3.5A)
SAM  A 306 (-4.2A)
SAM  A 306 (-2.2A)
SAM  A 306 ( 4.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
SAM  A 306 ( 2.9A)
 0.00A 5n5dA-5n5dA:
43.4		 5n5dA-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 7 PHE A  67
SER A  72
ILE A  88
GLU A  89
ASN A 141
 SAM  A 306 (-4.2A)
None
SAM  A 306 ( 4.2A)
SAM  A 306 (-2.4A)
SAM  A 306 ( 2.9A)
 1.16A 5n5dA-5n5dA:
43.4		 5n5dA-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		11 / 12 LEU A  39
ALA A  40
VAL A  41
GLU A  63
TYR A  70
ILE A  88
GLU A  91
ALA A 118
PHE A 137
ALA A 140
TYR A 148
 SAM  A 306 (-3.5A)
SAM  A 306 (-3.3A)
SAM  A 306 (-3.4A)
SAM  A 306 ( 3.6A)
None
SAM  A 306 ( 4.2A)
None
SAM  A 306 (-3.5A)
BU3  A 301 (-4.1A)
SAM  A 306 (-3.6A)
None
 0.19A 5n5dB-5n5dA:
40.6		 5n5dB-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		10 / 12 VAL A  41
GLU A  63
TYR A  70
ILE A  88
TRP A  90
GLU A  91
ALA A 118
PHE A 137
ALA A 140
TYR A 148
 SAM  A 306 (-3.4A)
SAM  A 306 ( 3.6A)
None
SAM  A 306 ( 4.2A)
None
None
SAM  A 306 (-3.5A)
BU3  A 301 (-4.1A)
SAM  A 306 (-3.6A)
None
 0.98A 5n5dB-5n5dA:
40.6		 5n5dB-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		7 / 7 GLY A  65
PHE A  67
SER A  71
GLU A  89
ARG A 117
ASP A 139
ASN A 141
 SAM  A 306 (-3.2A)
SAM  A 306 (-4.2A)
SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
None
SAM  A 306 (-2.3A)
SAM  A 306 ( 2.9A)
 0.38A 5n5dB-5n5dA:
40.6		 5n5dB-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		6 / 7 GLY A  65
PHE A  67
SER A  72
GLU A  89
ARG A 117
ASN A 141
 SAM  A 306 (-3.2A)
SAM  A 306 (-4.2A)
None
SAM  A 306 (-2.4A)
None
SAM  A 306 ( 2.9A)
 1.12A 5n5dB-5n5dA:
40.6		 5n5dB-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 VAL A  41
GLY A  65
ALA A 118
ALA A 140
TYR A 148
 SAM  A 306 (-3.4A)
SAM  A 306 (-3.2A)
SAM  A 306 (-3.5A)
SAM  A 306 (-3.6A)
None
 0.39A 5x7fA-5n5dA:
26.7		 5x7fA-5n5dA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 6 GLY A  69
TYR A  70
LEU A  85
VAL A 107
 None
 0.99A 5x80A-5n5dA:
undetectable
5x80B-5n5dA:
undetectable		 5x80A-5n5dA:
25.23
5x80B-5n5dA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		5 / 12 GLU A  63
GLY A  65
TYR A  70
ALA A 118
ALA A 140
 SAM  A 306 ( 3.6A)
SAM  A 306 (-3.2A)
None
SAM  A 306 (-3.5A)
SAM  A 306 (-3.6A)
 0.47A 5zw4A-5n5dA:
25.0		 5zw4A-5n5dA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 8 ASP A 175
ASP A 177
HIS A 178
PRO A 179
 BU3  A 302 (-2.8A)
BU3  A 302 (-4.2A)
GOL  A 304 ( 3.6A)
BU3  A 302 ( 4.1A)
 1.06A 6ag0C-5n5dA:
undetectable		 6ag0C-5n5dA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5n5d METHYLTRANSFERASE
(Streptomyces
regensis) 		4 / 7 ASP A 165
ASP A 139
LYS A 210
TYR A  70
 BU3  A 301 (-2.7A)
SAM  A 306 (-2.3A)
None
None
 1.41A 6g31G-5n5dA:
undetectable		 6g31G-5n5dA:
14.41