SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		4 / 6 ASP O 397
LEU O 400
VAL O 401
ILE O 404
 None
 0.34A 1s9qA-5n5zO:
undetectable		 1s9qA-5n5zO:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		4 / 7 PHE O 505
MET O 509
VAL O 510
SER O 512
 None
 0.83A 1wrlA-5n5zO:
undetectable
1wrlB-5n5zO:
undetectable		 1wrlA-5n5zO:
8.77
1wrlB-5n5zO:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		5 / 12 ALA O 476
LEU O 446
ARG O 452
PHE O 505
LEU O 502
 None
 1.25A 1xdkB-5n5zO:
undetectable		 1xdkB-5n5zO:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		4 / 6 PHE O 528
ARG O 530
ASN O 523
ASN O 549
 None
 1.22A 2nyrA-5n5zO:
undetectable		 2nyrA-5n5zO:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WNC_A_TKTA300_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		5 / 10 TYR O 423
TYR O 591
TYR O 376
GLN O 589
ILE O 418
 None
 1.28A 2wncA-5n5zO:
undetectable
2wncE-5n5zO:
undetectable		 2wncA-5n5zO:
15.85
2wncE-5n5zO:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		4 / 6 TYR O 423
TYR O 591
TYR O 376
ILE O 418
 None
 1.27A 2xz5A-5n5zO:
undetectable
2xz5B-5n5zO:
undetectable		 2xz5A-5n5zO:
16.06
2xz5B-5n5zO:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		4 / 8 ILE O 418
TYR O 423
TYR O 591
TYR O 376
 None
 1.25A 2xz5A-5n5zO:
undetectable
2xz5C-5n5zO:
undetectable		 2xz5A-5n5zO:
16.06
2xz5C-5n5zO:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		4 / 7 ILE O 418
TYR O 423
TYR O 591
TYR O 376
 None
 1.26A 2xz5D-5n5zO:
undetectable
2xz5E-5n5zO:
undetectable		 2xz5D-5n5zO:
16.06
2xz5E-5n5zO:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		5 / 10 ILE O 240
ILE O 237
ILE O 384
SER O 340
LEU O 233
 None
 1.10A 3o1xA-5n5zO:
undetectable		 3o1xA-5n5zO:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		5 / 10 ILE O 240
ILE O 237
ILE O 384
SER O 340
LEU O 233
 None
 1.06A 3qgzA-5n5zO:
undetectable		 3qgzA-5n5zO:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		3 / 3 PHE O  55
SER O  58
GLN O  70
 None
 0.81A 3smtA-5n5zO:
undetectable		 3smtA-5n5zO:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		3 / 3 GLN O 390
PHE O 386
TYR O 427
 None
 0.97A 3ucjB-5n5zO:
undetectable		 3ucjB-5n5zO:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		3 / 3 GLN O 390
PHE O 386
TYR O 427
 None
 0.97A 3ucjA-5n5zO:
undetectable		 3ucjA-5n5zO:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		5 / 12 LEU O 100
LEU O  97
LEU O  93
ILE O  74
ILE O 119
 None
 0.98A 4a7aB-5n5zO:
undetectable		 4a7aB-5n5zO:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		3 / 3 TYR O 482
ARG O 430
SER O 426
 None
 0.78A 4khpI-5n5zO:
undetectable
4khpJ-5n5zO:
undetectable		 4khpI-5n5zO:
11.56
4khpJ-5n5zO:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		3 / 3 SER O 407
ALA O 409
VAL O 410
 None
 0.61A 4x1iA-5n5zO:
undetectable		 4x1iA-5n5zO:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		3 / 3 LYS O  65
ASP O  62
ARG O 106
 None
 1.02A 5jwaA-5n5zO:
undetectable
5jwaH-5n5zO:
undetectable		 5jwaA-5n5zO:
21.52
5jwaH-5n5zO:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3
(Saccharomyces
cerevisiae) 		4 / 7 PHE O 491
ALA O 429
GLY O 425
TYR O 427
 None
 1.04A 5uxdA-5n5zO:
undetectable		 5uxdA-5n5zO:
17.14