SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 5 GLU A 159
GLY A 157
THR A 162
PHE A 186
 None
 1.16A 1icrA-5n6cA:
undetectable
1icrB-5n6cA:
undetectable		 1icrA-5n6cA:
17.05
1icrB-5n6cA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 THR A 162
PHE A 186
GLU A 159
GLY A 157
 None
 1.16A 1kqbA-5n6cA:
undetectable
1kqbB-5n6cA:
undetectable		 1kqbA-5n6cA:
undetectable
1kqbB-5n6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ALA A 223
PHE A 222
ALA A 248
LEU A 245
 None
 0.94A 2bxmA-5n6cA:
undetectable		 2bxmA-5n6cA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A  51
GLY A  50
LEU A  10
PHE A 303
LEU A  15
 None
 0.85A 3gwvA-5n6cA:
undetectable		 3gwvA-5n6cA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ASP A  84
ARG A  90
ALA A  61
 None
 0.78A 3mbgC-5n6cA:
undetectable		 3mbgC-5n6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 217
ILE A 196
ILE A 239
ALA A 235
VAL A 188
 None
None
None
NAD  A 402 (-3.6A)
None
 1.23A 3vw1D-5n6cA:
undetectable		 3vw1D-5n6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ASP A  81
ARG A 236
GLY A 238
HIS A 283
 None
TLA  A 401 ( 2.7A)
None
TLA  A 401 ( 3.8A)
 0.98A 4oltA-5n6cA:
undetectable		 4oltA-5n6cA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ASP A  81
ARG A 236
GLY A 238
HIS A 283
 None
TLA  A 401 ( 2.7A)
None
TLA  A 401 ( 3.8A)
 1.00A 4oltB-5n6cA:
undetectable		 4oltB-5n6cA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 217
ASN A 218
GLY A 215
LEU A 151
GLN A 224
 None
 1.39A 4p6xA-5n6cA:
undetectable		 4p6xA-5n6cA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 217
ASN A 218
GLY A 215
LEU A 151
GLN A 224
 None
 1.41A 4p6xE-5n6cA:
undetectable		 4p6xE-5n6cA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 217
ASN A 218
GLY A 215
LEU A 151
GLN A 224
 None
 1.43A 4p6xI-5n6cA:
undetectable		 4p6xI-5n6cA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A  98
SER A  55
ALA A 286
SER A 287
 None
TLA  A 401 (-2.9A)
TLA  A 401 ( 3.2A)
None
 1.09A 5l5fY-5n6cA:
undetectable
5l5fZ-5n6cA:
undetectable		 5l5fY-5n6cA:
15.46
5l5fZ-5n6cA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A 152
ILE A 150
LEU A 210
VAL A 240
ILE A 239
 NAD  A 402 (-3.4A)
None
None
None
None
 1.13A 6dgxB-5n6cA:
undetectable		 6dgxB-5n6cA:
21.11