SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 PHE A 722
PHE A 703
ILE A 573
TYR A 569
ALA A 758
 None
 1.39A 1fm4A-5n6uA:
undetectable		 1fm4A-5n6uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 9 ASP A  85
ASN A 365
ILE A 335
ILE A 362
THR A  86
 None
 1.21A 1j3jB-5n6uA:
undetectable		 1j3jB-5n6uA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 ILE A 551
ILE A 550
TYR A 567
GLN A 512
ALA A 543
 None
 1.08A 1ki7A-5n6uA:
undetectable		 1ki7A-5n6uA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 PHE A 591
TYR A 264
PRO A 317
 None
 0.98A 1mcnA-5n6uA:
4.7
1mcnB-5n6uA:
3.5
1mcnP-5n6uA:
undetectable		 1mcnA-5n6uA:
12.40
1mcnB-5n6uA:
12.40
1mcnP-5n6uA:
0.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 LEU A 729
THR A 581
LEU A 759
PHE A 495
HIS A 557
 None
 0.87A 1mx1C-5n6uA:
undetectable		 1mx1C-5n6uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 7 VAL A 153
VAL A 400
CYH A 421
ARG A 438
 None
 1.25A 1t46A-5n6uA:
undetectable		 1t46A-5n6uA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 PHE A 311
ARG A 587
ASN A 353
 None
 0.63A 1xzxX-5n6uA:
undetectable		 1xzxX-5n6uA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 LYS A 590
ASP A 717
ASP A 772
 None
 0.74A 2br4A-5n6uA:
undetectable		 2br4A-5n6uA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 7 ARG A 410
ASN A 365
ASP A 366
GLY A  83
 None
 0.78A 2f6dA-5n6uA:
undetectable		 2f6dA-5n6uA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 6 LEU A 276
LEU A 284
ILE A 211
ARG A 188
 None
 0.96A 2rlfC-5n6uA:
undetectable
2rlfD-5n6uA:
undetectable		 2rlfC-5n6uA:
5.29
2rlfD-5n6uA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 5 PHE A 722
PHE A 723
LEU A 694
PHE A 692
 None
 0.99A 2y69P-5n6uA:
undetectable
2y69W-5n6uA:
undetectable		 2y69P-5n6uA:
14.23
2y69W-5n6uA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 5 TYR A 623
GLU A 771
ARG A 346
ASP A 772
 None
 1.49A 2yqzA-5n6uA:
undetectable		 2yqzA-5n6uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 5 TYR A 623
GLU A 771
ARG A 346
ASP A 772
 None
 1.46A 2yqzB-5n6uA:
undetectable		 2yqzB-5n6uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 PRO A 514
GLU A 566
TYR A 567
 None
 0.73A 2zmbA-5n6uA:
undetectable		 2zmbA-5n6uA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 MET A 103
GLU A 364
ASN A 602
 None
 1.08A 3a27A-5n6uA:
undetectable		 3a27A-5n6uA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 5 PHE A 722
PHE A 723
LEU A 694
PHE A 692
 None
 1.06A 3abmP-5n6uA:
undetectable
3abmW-5n6uA:
undetectable		 3abmP-5n6uA:
14.23
3abmW-5n6uA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 ILE A 225
ILE A 249
VAL A 194
PHE A 291
PHE A 223
 None
 1.08A 3b2rA-5n6uA:
undetectable		 3b2rA-5n6uA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 TYR A 390
ILE A 362
GLY A 361
GLY A 360
ALA A 386
 None
 0.77A 3jayA-5n6uA:
undetectable		 3jayA-5n6uA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 TYR A 390
ILE A 362
GLY A 361
GLY A 360
ALA A 386
 None
 0.83A 3jb2A-5n6uA:
undetectable		 3jb2A-5n6uA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 7 TYR A 553
PHE A 495
VAL A 488
GLY A 497
 None
 1.13A 3kmoB-5n6uA:
undetectable		 3kmoB-5n6uA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 5 ARG A 727
LEU A 577
ARG A 552
ILE A 550
 None
 1.28A 3ln1D-5n6uA:
undetectable		 3ln1D-5n6uA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 10 MET A 378
ASN A 353
PHE A 319
PRO A 261
TYR A 264
 None
 1.45A 3r58A-5n6uA:
8.5		 3r58A-5n6uA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 MET A 378
ASN A 353
PHE A 319
PRO A 261
TYR A 264
 None
 1.40A 3r94A-5n6uA:
8.1		 3r94A-5n6uA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 PHE A 331
CYH A  28
HIS A  30
 None
 1.25A 3u9fF-5n6uA:
undetectable		 3u9fF-5n6uA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 PHE A 331
CYH A  28
HIS A  30
 None
 1.23A 3u9fG-5n6uA:
undetectable		 3u9fG-5n6uA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 PHE A 331
CYH A  28
HIS A  30
 None
 1.24A 3u9fS-5n6uA:
undetectable		 3u9fS-5n6uA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 TYR A 363
MET A 354
LEU A 419
 None
 0.93A 3vw1D-5n6uA:
undetectable		 3vw1D-5n6uA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 ASN A 476
TRP A 428
ASP A 501
 None
 1.27A 4a7tA-5n6uA:
5.6
4a7tF-5n6uA:
5.9		 4a7tA-5n6uA:
10.67
4a7tF-5n6uA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 PHE A 703
LEU A 570
ILE A 573
TYR A 569
ALA A 758
 None
 1.30A 4a83A-5n6uA:
undetectable		 4a83A-5n6uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 PHE A 722
LEU A 570
ILE A 573
TYR A 569
ALA A 758
 None
 1.38A 4a83A-5n6uA:
undetectable		 4a83A-5n6uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 7 ASN A 733
LEU A 731
GLY A 804
TYR A 805
 None
 0.97A 4cp3A-5n6uA:
undetectable
4cp3B-5n6uA:
undetectable		 4cp3A-5n6uA:
8.73
4cp3B-5n6uA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 10 ASP A   7
SER A 178
GLU A  80
GLU A  82
GLU A 108
 None
 1.25A 4dfbB-5n6uA:
1.0		 4dfbB-5n6uA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		6 / 12 PHE A 383
GLY A 422
SER A 467
ASN A 426
ILE A 446
VAL A 450
 None
 1.43A 4dx5B-5n6uA:
undetectable		 4dx5B-5n6uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 ARG A 197
TYR A 270
ASN A 413
 None
 0.97A 4ffwB-5n6uA:
undetectable		 4ffwB-5n6uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 GLY A 582
ILE A 506
ASN A 485
GLY A 595
ASN A 502
 None
 1.09A 4obwC-5n6uA:
undetectable		 4obwC-5n6uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 GLY A 582
ILE A 506
ASN A 485
GLY A 595
ASN A 502
 None
 1.12A 4obwD-5n6uA:
undetectable		 4obwD-5n6uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 10 ASP A 220
LEU A 240
LEU A 247
ILE A 249
LEU A 209
 None
 1.06A 4odoC-5n6uA:
undetectable		 4odoC-5n6uA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 11 ASP A 220
LEU A 240
LEU A 247
ILE A 249
LEU A 209
 None
 1.05A 4odrA-5n6uA:
undetectable
4odrB-5n6uA:
undetectable		 4odrA-5n6uA:
7.44
4odrB-5n6uA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 6 ASP A 651
ARG A 587
GLY A 322
VAL A 626
 None
 1.08A 4oltA-5n6uA:
undetectable		 4oltA-5n6uA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 6 ASP A 651
ARG A 587
GLY A 322
VAL A 626
 None
 1.09A 4oltB-5n6uA:
undetectable		 4oltB-5n6uA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 11 PHE A 441
TYR A 464
GLU A 307
GLU A 479
GLY A 471
 None
 1.35A 4qb9F-5n6uA:
undetectable		 4qb9F-5n6uA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 5 LYS A 580
GLU A 584
ILE A 637
VAL A 706
 None
 1.44A 4tvtA-5n6uA:
undetectable		 4tvtA-5n6uA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 6 ASN A 806
GLU A 720
TYR A 778
PHE A 703
 None
 1.36A 4twdG-5n6uA:
undetectable
4twdH-5n6uA:
undetectable		 4twdG-5n6uA:
17.21
4twdH-5n6uA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		6 / 12 PHE A 383
GLY A 422
SER A 467
ASN A 426
ILE A 446
VAL A 450
 None
 1.42A 4u8vB-5n6uA:
undetectable		 4u8vB-5n6uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		6 / 12 PHE A 383
GLY A 422
SER A 467
ASN A 426
ILE A 446
VAL A 450
 None
 1.41A 4u8yB-5n6uA:
undetectable		 4u8yB-5n6uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		6 / 12 PHE A 383
GLY A 422
SER A 467
ASN A 426
ILE A 446
VAL A 450
 None
 1.43A 4u95B-5n6uA:
undetectable		 4u95B-5n6uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 ALA A  14
ASP A  17
TRP A  53
LEU A 126
LEU A  33
 None
 1.29A 4xi3A-5n6uA:
undetectable		 4xi3A-5n6uA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 LEU A 247
ILE A 249
LEU A 251
ILE A 207
VAL A 221
 None
 1.03A 4y0rA-5n6uA:
undetectable		 4y0rA-5n6uA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 LEU A 708
TYR A 705
PHE A 647
GLU A 584
LEU A 689
 None
 1.40A 5czyA-5n6uA:
undetectable		 5czyA-5n6uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 9 GLN A 381
PHE A 383
GLY A 422
SER A 467
ASN A 426
 None
 1.42A 5entC-5n6uA:
undetectable		 5entC-5n6uA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 9 PHE A 383
GLY A 422
SER A 467
ASN A 426
ILE A 446
 None
 1.30A 5entC-5n6uA:
undetectable		 5entC-5n6uA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 8 LEU A 343
LEU A 619
THR A 519
TYR A 616
TRP A 605
 None
 1.38A 5hbsA-5n6uA:
undetectable		 5hbsA-5n6uA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 ASP A  85
ILE A  84
GLU A  80
ARG A 410
GLY A  83
 None
 1.15A 5il1A-5n6uA:
undetectable		 5il1A-5n6uA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 TYR A 783
TYR A 705
GLN A 707
 None
 1.10A 5jsdA-5n6uA:
undetectable
5jsdB-5n6uA:
undetectable		 5jsdA-5n6uA:
24.47
5jsdB-5n6uA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 TYR A 783
TYR A 705
GLN A 707
 None
 1.09A 5jsdB-5n6uA:
undetectable
5jsdC-5n6uA:
undetectable		 5jsdB-5n6uA:
24.47
5jsdC-5n6uA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 5 ALA A 629
VAL A 626
LYS A 321
ILE A 598
 None
 1.03A 5of1A-5n6uA:
3.8		 5of1A-5n6uA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		5 / 12 ALA A  23
GLY A  27
GLY A 174
ILE A  84
LEU A  79
 None
 1.12A 5ul4A-5n6uA:
2.5		 5ul4A-5n6uA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		3 / 3 SER A 448
HIS A 427
TYR A 470
 None
 0.96A 5y2tA-5n6uA:
undetectable		 5y2tA-5n6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5n6u BETA-MANNOSIDASE
(Dictyoglomus
thermophilum) 		4 / 7 ILE A 377
LEU A 344
ILE A 598
ALA A 328
 None
 0.84A 6b5vA-5n6uA:
undetectable
6b5vC-5n6uA:
undetectable		 6b5vA-5n6uA:
6.93
6b5vC-5n6uA:
6.93