SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 11 THR E 114
THR E 117
ILE E 124
GLY E  53
THR E  77
 CLF  E 501 (-4.2A)
None
None
CLF  E 501 (-3.5A)
None
 1.01A 1gtnT-5n6yE:
undetectable
1gtnU-5n6yE:
undetectable		 1gtnT-5n6yE:
10.26
1gtnU-5n6yE:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 ALA E 447
GLY E 446
GLY E 443
ALA E 312
ASP E 287
 None
 0.94A 2c49A-5n6yE:
4.3		 2c49A-5n6yE:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 PRO E 302
LEU E 249
ALA E 248
THR E 251
ILE E 293
 None
 1.28A 2jjpA-5n6yE:
undetectable		 2jjpA-5n6yE:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		6 / 12 GLY E 259
GLY E  35
GLY E 161
GLU E 164
VAL E  60
THR E  57
 None
 1.36A 2wa2B-5n6yE:
undetectable		 2wa2B-5n6yE:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 6 MET E 216
PRO E 190
GLY E 191
TRP E 192
 None
 1.25A 2y7pA-5n6yE:
undetectable		 2y7pA-5n6yE:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 THR E 114
ILE E 112
ILE E 111
GLY E  52
ALA E  84
 CLF  E 501 (-4.2A)
None
None
None
None
 0.91A 2yvlA-5n6yE:
4.9		 2yvlA-5n6yE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 THR E 114
ILE E 112
GLY E  52
LEU E  49
ALA E  84
 CLF  E 501 (-4.2A)
None
None
None
None
 1.15A 2yvlB-5n6yE:
5.0		 2yvlB-5n6yE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 THR E 114
ILE E 112
ILE E 111
GLY E  52
ALA E  84
 CLF  E 501 (-4.2A)
None
None
None
None
 0.89A 2yvlB-5n6yE:
5.0		 2yvlB-5n6yE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 THR E 114
ILE E 112
ILE E 111
GLY E  52
ALA E  84
 CLF  E 501 (-4.2A)
None
None
None
None
 0.92A 2yvlC-5n6yE:
4.7		 2yvlC-5n6yE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 8 GLY E 259
ALA E 255
THR E 279
ILE E 442
 None
 0.70A 3jusA-5n6yE:
undetectable		 3jusA-5n6yE:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 8 GLY E 259
ALA E 255
THR E 279
ILE E 442
 None
 0.70A 3jusA-5n6yE:
undetectable		 3jusA-5n6yE:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 9 GLY E 196
PRO E 195
GLY E 446
PHE E 428
PHE E  68
 None
 1.49A 3ko0H-5n6yE:
undetectable
3ko0I-5n6yE:
undetectable		 3ko0H-5n6yE:
12.18
3ko0I-5n6yE:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 11 GLN E 181
ASP E 244
ASN E 247
ALA E 176
ILE E 173
 None
 1.40A 3n23A-5n6yE:
undetectable		 3n23A-5n6yE:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		3 / 3 ALA E  75
VAL E  74
GLN E  37
 None
 0.72A 3of4B-5n6yE:
undetectable		 3of4B-5n6yE:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 7 ILE E  43
VAL E 108
ARG E 107
TYR E 145
 None
 1.01A 3p6hA-5n6yE:
undetectable		 3p6hA-5n6yE:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 7 ILE E 331
LYS E 439
PHE E 344
GLY E 451
 None
 1.08A 3sj0X-5n6yE:
undetectable		 3sj0X-5n6yE:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 LEU E  49
VAL E 239
ILE E  43
CYH E  46
LEU E 106
 None
 0.83A 3uvvB-5n6yE:
undetectable		 3uvvB-5n6yE:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		3 / 3 ASN E 132
GLU E 136
ARG E 133
 None
 1.07A 3wxoA-5n6yE:
undetectable		 3wxoA-5n6yE:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 8 VAL E 306
TYR E 204
TYR E 444
ILE E 301
 None
 1.29A 4bqtC-5n6yE:
undetectable
4bqtD-5n6yE:
undetectable		 4bqtC-5n6yE:
18.49
4bqtD-5n6yE:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 8 ASP E 359
GLY E 358
VAL E 159
VAL E 338
 None
 0.86A 4c5nC-5n6yE:
undetectable		 4c5nC-5n6yE:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 GLY E 259
GLY E  35
GLY E 161
GLU E 164
VAL E  60
 None
 0.93A 4ctjC-5n6yE:
2.9		 4ctjC-5n6yE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 8 GLY E 340
GLY E 282
VAL E 348
GLU E 347
 None
 0.76A 4fgzB-5n6yE:
undetectable		 4fgzB-5n6yE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		6 / 12 ASN E 260
ILE E 293
THR E 279
PRO E 280
VAL E 210
THR E 297
 None
 1.20A 4q5mA-5n6yE:
undetectable		 4q5mA-5n6yE:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 7 PHE E 205
LEU E 201
THR E 297
VAL E 188
 None
 1.01A 4wnvD-5n6yE:
undetectable		 4wnvD-5n6yE:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 10 TYR E 281
GLY E 451
SER E 441
GLY E 443
VAL E 348
 None
 1.09A 5i6xA-5n6yE:
undetectable		 5i6xA-5n6yE:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 7 LEU E 355
VAL E 353
ILE E 454
VAL E 329
 None
 1.18A 5jh7C-5n6yE:
undetectable		 5jh7C-5n6yE:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 GLY E 259
GLY E  35
GLY E 161
GLU E 164
VAL E  60
 None
 0.98A 5njvD-5n6yE:
undetectable		 5njvD-5n6yE:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		3 / 3 HIS E 334
GLU E 258
TRP E 192
 None
 1.20A 5odiD-5n6yE:
3.2		 5odiD-5n6yE:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		3 / 3 HIS E 334
GLU E 258
TRP E 192
 None
 1.22A 5odqD-5n6yE:
undetectable		 5odqD-5n6yE:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		3 / 3 HIS E 334
GLU E 258
TRP E 192
 None
 1.17A 5odrD-5n6yE:
3.3		 5odrD-5n6yE:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		5 / 12 TYR E  38
MET E 216
GLY E 191
VAL E 188
VAL E 193
 None
 1.23A 5ubbA-5n6yE:
undetectable		 5ubbA-5n6yE:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN
(Azotobacter
vinelandii) 		4 / 7 VAL E 108
ILE E 173
ILE E 242
ASP E 241
 None
 0.68A 5ywmX-5n6yE:
undetectable		 5ywmX-5n6yE:
12.11