SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5n72 WIPA
(Legionella
pneumophila) 		3 / 3 SER A 137
THR A  93
GLN A  89
 None
 0.81A 2fk8A-5n72A:
undetectable		 2fk8A-5n72A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5n72 WIPA
(Legionella
pneumophila) 		4 / 7 TYR A 384
VAL A 389
ILE A 298
ASP A 311
 None
 0.99A 2x45B-5n72A:
undetectable		 2x45B-5n72A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5n72 WIPA
(Legionella
pneumophila) 		4 / 7 TYR A 384
VAL A 389
ILE A 298
ASP A 311
 None
 0.97A 2x45C-5n72A:
undetectable		 2x45C-5n72A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5n72 WIPA
(Legionella
pneumophila) 		4 / 7 TYR A 384
VAL A 389
ILE A 298
ASP A 311
 None
 1.03A 3bu1A-5n72A:
undetectable		 3bu1A-5n72A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5n72 WIPA
(Legionella
pneumophila) 		4 / 7 ILE A 208
GLY A 214
VAL A 265
LEU A 328
 None
ACT  A 504 ( 4.9A)
None
None
 0.86A 3elzA-5n72A:
undetectable		 3elzA-5n72A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 10 ILE A 208
GLY A 214
TYR A 221
VAL A 265
LEU A 328
 None
ACT  A 504 ( 4.9A)
None
None
None
 1.01A 3elzB-5n72A:
undetectable		 3elzB-5n72A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 10 ILE A 218
SER A 243
SER A 187
LEU A 210
SER A 211
 None
ACT  A 504 (-2.6A)
ACT  A 504 (-4.0A)
None
None
 1.41A 3ik6B-5n72A:
undetectable
3ik6E-5n72A:
undetectable		 3ik6B-5n72A:
20.05
3ik6E-5n72A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 12 LEU A  42
PHE A  41
ILE A 175
LEU A 199
ASP A 189
 None
 1.22A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0C-5n72A:
undetectable
3ko0D-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0C-5n72A:
14.02
3ko0D-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 12 LEU A 199
PHE A 198
ILE A  48
LEU A  42
ASP A 189
 None
 1.25A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0C-5n72A:
undetectable
3ko0D-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0C-5n72A:
14.02
3ko0D-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 11 ASP A 189
LEU A  42
LEU A 199
PHE A 198
ILE A  48
 None
 1.28A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0I-5n72A:
undetectable
3ko0J-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0I-5n72A:
14.02
3ko0J-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 11 ASP A 189
LEU A 199
LEU A  42
PHE A  41
ILE A 175
 None
 1.24A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0I-5n72A:
undetectable
3ko0J-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0I-5n72A:
14.02
3ko0J-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 12 ASP A 189
LEU A 199
LEU A  42
PHE A  41
ILE A 175
 None
 1.21A 3ko0M-5n72A:
undetectable
3ko0N-5n72A:
undetectable
3ko0O-5n72A:
undetectable
3ko0P-5n72A:
undetectable		 3ko0M-5n72A:
14.02
3ko0N-5n72A:
14.02
3ko0O-5n72A:
14.02
3ko0P-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 12 MET A 336
LEU A 362
LEU A 340
ILE A 275
VAL A 307
 None
 1.22A 4f4dB-5n72A:
undetectable		 4f4dB-5n72A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5n72 WIPA
(Legionella
pneumophila) 		4 / 5 TYR A 364
ILE A 363
ASN A 351
ILE A 346
 None
 1.05A 4jtpA-5n72A:
undetectable		 4jtpA-5n72A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 9 LEU A 178
GLY A 394
ILE A 276
LEU A 287
VAL A 392
 None
 1.05A 4x3mB-5n72A:
undetectable		 4x3mB-5n72A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 11 PHE A 217
VAL A 265
LYS A 270
GLU A 266
LEU A 261
 ACT  A 504 (-4.5A)
None
None
None
None
 0.97A 4zmeA-5n72A:
undetectable		 4zmeA-5n72A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5n72 WIPA
(Legionella
pneumophila) 		5 / 10 PHE A 217
VAL A 265
LYS A 270
GLU A 266
LEU A 261
 ACT  A 504 (-4.5A)
None
None
None
None
 0.98A 4zmeB-5n72A:
undetectable		 4zmeB-5n72A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5n72 WIPA
(Legionella
pneumophila) 		3 / 3 VAL A 366
SER A 211
TRP A 367
 None
None
ACT  A 501 ( 4.6A)
 0.93A 5jwaA-5n72A:
undetectable		 5jwaA-5n72A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5n72 WIPA
(Legionella
pneumophila) 		4 / 5 TYR A  61
GLN A  62
GLY A  33
ILE A  39
 None
 1.28A 6debB-5n72A:
undetectable		 6debB-5n72A:
13.85