SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 ILE A 318
ALA A 320
PHE A 212
ILE A 224
ARG A 294
 None
8Q2  A 501 (-3.2A)
None
None
None
 1.20A 1dlsA-5n81A:
undetectable		 1dlsA-5n81A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.12A 1fkbA-5n81A:
undetectable		 1fkbA-5n81A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 THR A 188
TYR A 187
ILE A 117
ILE A 126
ALA A 228
 8Q2  A 501 ( 4.8A)
None
None
None
None
 1.30A 1jtxA-5n81A:
undetectable		 1jtxA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 ASN A 100
ALA A 183
ILE A  39
LEU A 226
PHE A 240
 None
 1.29A 1udtA-5n81A:
undetectable		 1udtA-5n81A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 MET A 230
LEU A 226
TYR A 266
THR A 256
ILE A 257
 None
 1.01A 1xoqA-5n81A:
undetectable		 1xoqA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.17A 2dg3A-5n81A:
undetectable		 2dg3A-5n81A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.11A 2dg4A-5n81A:
undetectable		 2dg4A-5n81A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.12A 2dg9A-5n81A:
undetectable		 2dg9A-5n81A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		6 / 12 GLY A 371
ALA A 413
ASP A 411
THR A 330
PRO A 349
ILE A 421
 None
None
8Q2  A 501 (-2.7A)
None
None
None
 1.43A 2nmyA-5n81A:
undetectable		 2nmyA-5n81A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 GLU A  99
SER A 248
ALA A 247
LEU A 272
ILE A 251
 None
 1.29A 2xkwB-5n81A:
undetectable		 2xkwB-5n81A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 MET A 230
LEU A 226
TYR A 266
THR A 256
ILE A 257
 None
 0.96A 3g4lC-5n81A:
undetectable		 3g4lC-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 ILE A 346
ILE A 357
GLU A 372
THR A 409
ILE A 375
 None
 0.95A 3kw4A-5n81A:
undetectable		 3kw4A-5n81A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 10 LEU A 226
VAL A 101
ILE A 104
TYR A 114
PHE A 240
 None
 1.17A 3kz7A-5n81A:
undetectable		 3kz7A-5n81A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 10 LEU A 249
VAL A 101
ILE A 104
TYR A 114
PHE A 240
 None
 1.25A 3kz7A-5n81A:
undetectable		 3kz7A-5n81A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 5 TYR A 317
PRO A 287
THR A 291
THR A 276
 None
None
None
8Q2  A 501 ( 4.9A)
 1.43A 3q07A-5n81A:
undetectable		 3q07A-5n81A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 5 TYR A 317
PRO A 287
THR A 291
THR A 276
 None
None
None
8Q2  A 501 ( 4.9A)
 1.41A 3q07B-5n81A:
undetectable		 3q07B-5n81A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 6 TRP A 311
LEU A 307
SER A 303
THR A 298
 None
 1.44A 3ropA-5n81A:
2.8		 3ropA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 7 PHE A 232
ASP A 233
GLY A 300
THR A 324
 8Q2  A 501 (-4.6A)
8Q2  A 501 (-2.7A)
8Q2  A 501 (-3.2A)
8Q2  A 501 (-3.7A)
 0.26A 3vnsA-5n81A:
50.2		 3vnsA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 LEU A 105
VAL A 107
GLY A 111
ALA A 110
LEU A 173
 None
 1.16A 4coxC-5n81A:
undetectable		 4coxC-5n81A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 LEU A 226
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.05A 4odrA-5n81A:
undetectable
4odrB-5n81A:
undetectable		 4odrA-5n81A:
23.00
4odrB-5n81A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 9 ALA A 381
ILE A  89
VAL A 115
GLY A 197
THR A 188
 None
None
None
None
8Q2  A 501 ( 4.8A)
 1.00A 4r20B-5n81A:
undetectable		 4r20B-5n81A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 GLU A  81
LEU A  79
LEU A  75
LEU A 160
LEU A 139
 None
 1.22A 4wg0I-5n81A:
undetectable
4wg0J-5n81A:
undetectable
4wg0K-5n81A:
undetectable		 4wg0I-5n81A:
undetectable
4wg0J-5n81A:
undetectable
4wg0K-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 7 PHE A 232
ASP A 233
GLY A 300
THR A 324
 8Q2  A 501 (-4.6A)
8Q2  A 501 (-2.7A)
8Q2  A 501 (-3.2A)
8Q2  A 501 (-3.7A)
 0.27A 4zxiA-5n81A:
49.6		 4zxiA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.16A 5hw8D-5n81A:
undetectable		 5hw8D-5n81A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 11 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.12A 5hw8E-5n81A:
undetectable		 5hw8E-5n81A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.04A 5hw8B-5n81A:
undetectable
5hw8F-5n81A:
undetectable
5hw8G-5n81A:
undetectable		 5hw8B-5n81A:
14.29
5hw8F-5n81A:
14.29
5hw8G-5n81A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		3 / 3 VAL A 378
SER A 210
MET A 241
 None
 0.90A 5ikqA-5n81A:
undetectable		 5ikqA-5n81A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 7 PHE A 232
ASP A 233
GLY A 300
GLY A 322
 8Q2  A 501 (-4.6A)
8Q2  A 501 (-2.7A)
8Q2  A 501 (-3.2A)
8Q2  A 501 (-4.1A)
 0.52A 5n9xA-5n81A:
49.3		 5n9xA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 VAL A 218
LEU A 327
LEU A 208
SER A 245
GLY A 225
 None
8Q2  A 501 (-4.9A)
None
None
None
 1.04A 6b0iB-5n81A:
undetectable		 6b0iB-5n81A:
17.07