SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5n8n TYPE VI SECRETION
PROTEIN, FAMILY
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 107
MET A 104
PHE A  70
LEU A  46
 None
 1.25A 1ea1A-5n8nA:
undetectable		 1ea1A-5n8nA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA B 346
ILE B 337
PRO B 352
GLU B 342
 None
 1.10A 1oniA-5n8nB:
undetectable
1oniB-5n8nB:
undetectable		 1oniA-5n8nB:
undetectable
1oniB-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA B 346
ILE B 337
PRO B 352
GLU B 342
 None
 1.07A 1oniB-5n8nB:
undetectable
1oniC-5n8nB:
undetectable		 1oniB-5n8nB:
undetectable
1oniC-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE B 337
PRO B 352
GLU B 342
ALA B 346
 None
 1.11A 1oniD-5n8nB:
undetectable
1oniE-5n8nB:
undetectable		 1oniD-5n8nB:
undetectable
1oniE-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE B 337
PRO B 352
GLU B 342
ALA B 346
 None
 1.06A 1oniG-5n8nB:
undetectable
1oniI-5n8nB:
undetectable		 1oniG-5n8nB:
undetectable
1oniI-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU B 391
SER B 195
CYH B 162
LEU B 231
LEU B 179
 None
 1.12A 1s19A-5n8nB:
undetectable		 1s19A-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LYS B 123
LEU B 242
PHE B 350
LEU B 179
LEU B 231
 None
 0.98A 2bxqA-5n8nB:
undetectable		 2bxqA-5n8nB:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 THR B 217
PHE B 220
THR B 221
ARG B 229
 None
 1.00A 2kotA-5n8nB:
undetectable		 2kotA-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 PHE B 220
ILE B 219
LEU B 353
ILE B 337
THR B 243
 None
 1.34A 3em0B-5n8nB:
undetectable		 3em0B-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 PRO B 192
ILE B 194
SER B 369
SER B 237
GLY B 241
 None
 1.27A 3ijxB-5n8nB:
undetectable
3ijxD-5n8nB:
undetectable		 3ijxB-5n8nB:
14.40
3ijxD-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
TYPE VI SECRETION
PROTEIN, FAMILY
(Pseudomonas
aeruginosa) 		4 / 7 LEU B 101
TYR B 284
MET A  43
ARG B 304
 None
 1.24A 3ik3A-5n8nB:
undetectable		 3ik3A-5n8nB:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 ILE B 194
SER B 369
SER B 237
GLY B 241
SER B 186
 None
 1.16A 3ik6B-5n8nB:
undetectable
3ik6E-5n8nB:
undetectable		 3ik6B-5n8nB:
14.40
3ik6E-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 SER B 186
ILE B 194
SER B 369
SER B 237
GLY B 241
 None
 1.16A 3ik6B-5n8nB:
undetectable
3ik6E-5n8nB:
undetectable		 3ik6B-5n8nB:
14.40
3ik6E-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 PRO B 192
ILE B 194
SER B 369
SER B 237
GLY B 241
 None
 1.21A 3iluB-5n8nB:
undetectable
3iluE-5n8nB:
undetectable		 3iluB-5n8nB:
14.40
3iluE-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 SER B 186
ILE B 194
SER B 369
SER B 237
GLY B 241
 None
 1.21A 3iluB-5n8nB:
undetectable
3iluE-5n8nB:
undetectable		 3iluB-5n8nB:
14.40
3iluE-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ILE B 194
SER B 369
SER B 237
GLY B 241
PRO B 192
 None
 1.23A 3iluB-5n8nB:
undetectable
3iluE-5n8nB:
undetectable		 3iluB-5n8nB:
14.40
3iluE-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ILE B 194
SER B 369
SER B 237
GLY B 241
SER B 186
 None
 1.21A 3iluB-5n8nB:
undetectable
3iluE-5n8nB:
undetectable		 3iluB-5n8nB:
14.40
3iluE-5n8nB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 LEU B 315
ALA B 363
PHE B 361
ASN B 289
 None
 1.50A 3vaqA-5n8nB:
1.6		 3vaqA-5n8nB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 LEU B 315
ALA B 363
PHE B 361
ASN B 289
 None
 1.48A 3vasA-5n8nB:
1.6		 3vasA-5n8nB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 VAL B 455
VAL B 457
TYR B 432
TRP B 424
LEU B 404
 None
 1.47A 4jq4A-5n8nB:
0.9		 4jq4A-5n8nB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU B 119
MET B 182
LEU B 163
ILE B 116
 None
 1.04A 4okxA-5n8nB:
undetectable		 4okxA-5n8nB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 ARG B 341
MET B 204
GLU B 209
LEU B 210
 None
 1.15A 4v2oA-5n8nB:
undetectable
4v2oC-5n8nB:
undetectable		 4v2oA-5n8nB:
undetectable
4v2oC-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 TRP B 138
GLU B 181
ASP B 236
 None
 0.99A 5gqbA-5n8nB:
undetectable		 5gqbA-5n8nB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 CYH B 300
PHE B 294
ILE B 116
GLY B 161
 None
 1.39A 5hesB-5n8nB:
undetectable		 5hesB-5n8nB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 PRO B 192
ILE B 194
SER B 369
SER B 237
GLY B 241
 None
 1.46A 5weoA-5n8nB:
undetectable
5weoD-5n8nB:
5.0		 5weoA-5n8nB:
5.86
5weoD-5n8nB:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
TYPE VI SECRETION
PROTEIN, FAMILY
(Pseudomonas
aeruginosa) 		5 / 9 ILE B  67
ARG A 126
ALA A 130
LEU A 129
ALA A 125
 None
 1.08A 5zgbB-5n8nB:
undetectable		 5zgbB-5n8nB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN
TYPE VI SECRETION
PROTEIN, FAMILY
(Pseudomonas
aeruginosa) 		5 / 9 ILE B  67
ARG A 126
ALA A 130
LEU A 129
ALA A 125
 None
 1.03A 5zghB-5n8nB:
undetectable		 5zghB-5n8nB:
20.65