SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 11 GLU A 890
ARG A1276
LEU A 875
ALA A 195
GLY A 197
 None
 1.12A 1cmaA-5n8oA:
undetectable
1cmaB-5n8oA:
undetectable		 1cmaA-5n8oA:
4.84
1cmaB-5n8oA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 10 GLU A 890
ARG A1276
LEU A 875
ALA A 195
GLY A 197
 None
 1.10A 1cmcA-5n8oA:
undetectable
1cmcB-5n8oA:
undetectable		 1cmcA-5n8oA:
4.84
1cmcB-5n8oA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 4 THR A 166
LEU A 139
VAL A 162
LEU A  82
 None
 0.76A 1fbmB-5n8oA:
undetectable		 1fbmB-5n8oA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 10 ASN A 799
ARG A 448
SER A 437
GLY A 438
ASP A 536
 None
 1.23A 1ho5B-5n8oA:
undetectable		 1ho5B-5n8oA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 ARG A1082
LEU A1047
VAL A1075
GLY A1076
 None
 0.86A 1hrkA-5n8oA:
2.4		 1hrkA-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 ARG A1248
LEU A1254
PRO A1385
VAL A1367
 None
 1.04A 1hrkA-5n8oA:
2.4		 1hrkA-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 ARG A1082
LEU A1047
VAL A1075
GLY A1076
 None
 0.84A 1hrkB-5n8oA:
2.6		 1hrkB-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 GLU A1323
ARG A1322
ALA A 864
ARG A 358
GLU A 355
 None
 1.47A 1ki7B-5n8oA:
undetectable		 1ki7B-5n8oA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 ALA A 195
GLY A 197
GLU A 890
ARG A1276
LEU A 875
 None
 1.08A 1mj2A-5n8oA:
undetectable
1mj2B-5n8oA:
undetectable		 1mj2A-5n8oA:
4.55
1mj2B-5n8oA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 ALA A 195
GLY A 197
GLU A 890
ARG A1276
LEU A 875
 None
 1.09A 1mj2C-5n8oA:
undetectable
1mj2D-5n8oA:
undetectable		 1mj2C-5n8oA:
4.55
1mj2D-5n8oA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 ALA A 195
GLY A 197
GLU A 890
ARG A1276
LEU A 875
 None
 1.10A 1mjoC-5n8oA:
undetectable
1mjoD-5n8oA:
undetectable		 1mjoC-5n8oA:
4.55
1mjoD-5n8oA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 SER A 602
GLY A 603
ARG A 576
 None
 0.55A 1t9wA-5n8oA:
2.7		 1t9wA-5n8oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 10 GLU A1417
LEU A1436
SER A1437
ARG A1438
ALA A1402
 None
 1.42A 1wygA-5n8oA:
2.8		 1wygA-5n8oA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 5 LEU A 814
PRO A 567
ALA A 568
ILE A 570
 None
 0.97A 2aofB-5n8oA:
undetectable		 2aofB-5n8oA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 LYS A 512
ASP A 733
ASP A 469
 None
 1.01A 2br4D-5n8oA:
undetectable		 2br4D-5n8oA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 ARG A1248
LEU A1254
PRO A1385
VAL A1367
 None
 1.04A 2hrcA-5n8oA:
undetectable		 2hrcA-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 ILE A1337
GLN A1258
LEU A1254
ASP A1343
 None
 1.02A 2qqcB-5n8oA:
undetectable
2qqcC-5n8oA:
undetectable		 2qqcB-5n8oA:
4.67
2qqcC-5n8oA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 LEU A1254
ASP A1343
ILE A1337
GLN A1258
 None
 1.03A 2qqcI-5n8oA:
undetectable
2qqcL-5n8oA:
undetectable		 2qqcI-5n8oA:
2.35
2qqcL-5n8oA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 TYR A  16
PRO A 154
PHE A 234
TRP A 277
 None
 1.29A 3bjwD-5n8oA:
undetectable		 3bjwD-5n8oA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 ASN A1241
HIS A1245
VAL A1339
 None
 0.84A 3elzB-5n8oA:
undetectable		 3elzB-5n8oA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 9 GLY A1098
ASP A1070
VAL A 990
VAL A 989
GLN A1115
 None
 1.42A 3fi0K-5n8oA:
undetectable		 3fi0K-5n8oA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 9 GLY A1098
ASP A1070
VAL A 990
VAL A 989
GLN A1115
 None
 1.44A 3fi0M-5n8oA:
undetectable		 3fi0M-5n8oA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 6 LEU A 547
GLN A 509
LEU A 513
GLU A 511
 None
 1.00A 3h5gB-5n8oA:
undetectable
3h5gC-5n8oA:
undetectable		 3h5gB-5n8oA:
1.59
3h5gC-5n8oA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 ARG A1276
PRO A  87
SER A  89
GLY A 222
 None
 0.99A 3hcrB-5n8oA:
undetectable		 3hcrB-5n8oA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 4 PRO A1472
TYR A 926
GLY A 927
THR A 928
 None
 1.17A 3ib0A-5n8oA:
undetectable		 3ib0A-5n8oA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 9 ALA A1288
LEU A1309
GLU A1327
ILE A1300
LEU A1277
 None
 1.28A 3jw3B-5n8oA:
undetectable		 3jw3B-5n8oA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 5 SER A 936
ARG A1270
GLY A1272
GLU A1273
 None
 1.35A 3k9fA-5n8oA:
2.4
3k9fB-5n8oA:
2.4
3k9fC-5n8oA:
undetectable		 3k9fA-5n8oA:
14.21
3k9fB-5n8oA:
14.21
3k9fC-5n8oA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 GLU A 657
VAL A 670
ALA A 767
ARG A 668
 None
 1.02A 3kp6B-5n8oA:
2.2		 3kp6B-5n8oA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 ASP A 508
SER A 472
ARG A 807
 None
 0.86A 3loqA-5n8oA:
undetectable		 3loqA-5n8oA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 6 GLN A 152
HIS A 157
HIS A 159
HIS A 146
 None
 1.23A 3nvcA-5n8oA:
undetectable		 3nvcA-5n8oA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 ALA A 800
GLY A 804
GLY A 538
SER A 537
ALA A 796
 None
 1.00A 3ou7B-5n8oA:
2.8		 3ou7B-5n8oA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 9 ILE A 361
ILE A 365
VAL A 339
THR A 381
ILE A 324
 None
 0.86A 3p4wB-5n8oA:
undetectable		 3p4wB-5n8oA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 10 ILE A 361
ILE A 365
VAL A 339
THR A 381
ILE A 324
 None
 0.88A 3p4wE-5n8oA:
undetectable		 3p4wE-5n8oA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 GLN A 866
GLU A1327
ARG A1275
GLU A1323
 None
 1.19A 3ql6A-5n8oA:
undetectable		 3ql6A-5n8oA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOU_A_ACTA228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 4 ALA A1390
ARG A 576
TYR A1356
ARG A1354
 None
 1.32A 3touA-5n8oA:
0.0		 3touA-5n8oA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOU_B_ACTB228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 4 ALA A1390
ARG A 576
TYR A1356
ARG A1354
 None
 1.17A 3touB-5n8oA:
0.0		 3touB-5n8oA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 GLN A 155
HIS A 157
HIS A 159
HIS A 146
 None
 1.04A 3w6hA-5n8oA:
undetectable		 3w6hA-5n8oA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 LEU A  60
ASP A  65
GLU A  57
HIS A  76
 None
 1.11A 4aq7A-5n8oA:
undetectable		 4aq7A-5n8oA:
19.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 TRP A1453
THR A1454
LEU A1155
LEU A1152
ILE A1457
 None
 1.07A 4c9oA-5n8oA:
undetectable		 4c9oA-5n8oA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 ALA A1415
ALA A1432
ALA A1402
THR A1231
 None
 0.95A 4du2A-5n8oA:
undetectable		 4du2A-5n8oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 7 ALA A1415
ALA A1432
ALA A1402
THR A1231
 None
 0.91A 4du2B-5n8oA:
undetectable		 4du2B-5n8oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 TYR A 558
GLN A 428
TRP A 560
 None
 1.16A 4kn2C-5n8oA:
undetectable		 4kn2C-5n8oA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 ARG A 198
GLU A 202
PHE A 901
 None
 0.92A 4kszA-5n8oA:
undetectable		 4kszA-5n8oA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 SER A 665
ASP A 667
GLN A 687
 None
 0.93A 4oltA-5n8oA:
undetectable
4oltB-5n8oA:
0.4		 4oltA-5n8oA:
11.03
4oltB-5n8oA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 PRO A  61
LEU A  60
GLN A 167
 None
 0.57A 4pevB-5n8oA:
undetectable		 4pevB-5n8oA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 10 ALA A 895
ALA A 891
ALA A 867
GLY A 900
THR A 899
 None
 1.02A 4qvyK-5n8oA:
undetectable
4qvyL-5n8oA:
undetectable		 4qvyK-5n8oA:
9.20
4qvyL-5n8oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 10 ALA A 895
ALA A 891
ALA A 867
GLY A 900
THR A 899
 None
 1.01A 4qvyY-5n8oA:
undetectable
4qvyZ-5n8oA:
undetectable		 4qvyY-5n8oA:
9.20
4qvyZ-5n8oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 GLN A 687
SER A 665
ASP A 667
 None
 0.89A 4qwpA-5n8oA:
0.5
4qwpB-5n8oA:
undetectable		 4qwpA-5n8oA:
10.96
4qwpB-5n8oA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 6 LEU A1066
LEU A1069
VAL A1095
PHE A1067
 None
 1.25A 4uswA-5n8oA:
undetectable		 4uswA-5n8oA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 6 ALA A 323
GLN A 322
LEU A 327
LEU A 646
 None
 1.14A 4xoyA-5n8oA:
undetectable		 4xoyA-5n8oA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 ASP A1468
ARG A1118
TYR A 926
 None
 0.99A 5a7mA-5n8oA:
undetectable		 5a7mA-5n8oA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 ASP A1468
ARG A1118
TYR A 926
 None
 0.99A 5a7mB-5n8oA:
undetectable		 5a7mB-5n8oA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 5 ARG A 978
GLY A 963
THR A 983
GLU A 982
 None
 1.17A 5btiA-5n8oA:
2.5
5btiB-5n8oA:
undetectable		 5btiA-5n8oA:
14.65
5btiB-5n8oA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 5 SER A 635
ARG A 605
GLY A 603
GLU A 606
 None
 1.10A 5btiA-5n8oA:
2.5
5btiB-5n8oA:
undetectable		 5btiA-5n8oA:
14.65
5btiB-5n8oA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 5 ARG A 978
GLY A 963
THR A 983
GLU A 982
 None
 1.16A 5btiC-5n8oA:
2.5
5btiD-5n8oA:
undetectable		 5btiC-5n8oA:
14.65
5btiD-5n8oA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 11 THR A  53
THR A  18
ALA A  10
GLY A  11
ALA A  13
 None
 1.36A 5bxnV-5n8oA:
undetectable
5bxnW-5n8oA:
undetectable		 5bxnV-5n8oA:
9.30
5bxnW-5n8oA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 ILE A 724
LEU A 634
VAL A 760
LEU A 727
MET A 745
 None
 1.27A 5bykA-5n8oA:
undetectable		 5bykA-5n8oA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 HIS A 106
ASN A 107
ARG A  32
HIS A 159
 None
 1.13A 5db5A-5n8oA:
undetectable
5db5B-5n8oA:
undetectable		 5db5A-5n8oA:
13.28
5db5B-5n8oA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 12 ILE A1394
ASP A1343
VAL A1364
LEU A1396
HIS A1245
 None
 1.11A 5km9B-5n8oA:
2.2		 5km9B-5n8oA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 VAL A 208
LEU A 102
VAL A 229
MET A 226
 None
 0.75A 5nujA-5n8oA:
undetectable		 5nujA-5n8oA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 8 ASN A1268
ARG A1270
ILE A1269
GLY A1272
 None
 0.95A 5nzxA-5n8oA:
undetectable		 5nzxA-5n8oA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 5 LEU A1155
VAL A1445
GLU A1417
LEU A1436
 None
 1.05A 5xooB-5n8oA:
undetectable		 5xooB-5n8oA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 GLY A 900
THR A 902
GLU A 903
 None
 0.64A 6b58A-5n8oA:
undetectable		 6b58A-5n8oA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		3 / 3 PHE A 587
ARG A 717
ALA A 786
 None
 0.71A 6ecfB-5n8oA:
undetectable		 6ecfB-5n8oA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5n8o DNA HELICASE I
(Escherichia
coli) 		4 / 6 GLN A 973
GLU A 967
ALA A1004
GLN A1001
 None
 1.23A 6f6jC-5n8oA:
undetectable
6f6jD-5n8oA:
undetectable		 6f6jC-5n8oA:
12.35
6f6jD-5n8oA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5n8o DNA HELICASE I
(Escherichia
coli) 		5 / 9 LEU A 175
SER A 176
PHE A 185
LEU A 120
VAL A 162
 None
 1.50A 6ftpA-5n8oA:
undetectable
6ftpB-5n8oA:
undetectable		 6ftpA-5n8oA:
4.26
6ftpB-5n8oA:
2.60