SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 720
LEU A 701
SER A 687
SER A 690
VAL A 738
 None
None
None
CA  A9017 (-4.8A)
None
 1.27A 1db1A-5n8pA:
undetectable		 1db1A-5n8pA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ALA A 426
SER A 407
SER A 405
THR A 403
 None
 0.91A 1dvxA-5n8pA:
undetectable		 1dvxA-5n8pA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 720
LEU A 701
SER A 687
SER A 690
VAL A 738
 None
None
None
CA  A9017 (-4.8A)
None
 1.32A 1ie9A-5n8pA:
undetectable		 1ie9A-5n8pA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 10 PHE A 834
GLY A 820
GLY A 817
THR A 816
ALA A 790
 None
 1.17A 2ej3B-5n8pA:
undetectable		 2ej3B-5n8pA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 11 SER A 250
LEU A 287
GLY A 289
LEU A 254
SER A 253
 None
None
CA  A9001 (-4.4A)
CA  A9003 ( 4.6A)
None
 0.99A 2qmmA-5n8pA:
undetectable
2qmmB-5n8pA:
undetectable		 2qmmA-5n8pA:
9.72
2qmmB-5n8pA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		6 / 11 SER A 250
LEU A 287
ILE A 316
GLY A 289
GLY A 290
SER A 253
 None
None
None
CA  A9001 (-4.4A)
CA  A9002 (-3.8A)
None
 1.41A 2qmmA-5n8pA:
undetectable
2qmmB-5n8pA:
undetectable		 2qmmA-5n8pA:
9.72
2qmmB-5n8pA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 5 LEU A 889
ASP A 905
ILE A 861
GLY A 900
 None
CA  A9012 ( 2.7A)
None
CA  A9012 ( 4.2A)
 0.93A 3bufA-5n8pA:
undetectable		 3bufA-5n8pA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 THR A 892
GLY A 894
ASN A 877
ASP A 878
ILE A 912
 CA  A9014 (-4.7A)
CA  A9014 ( 4.6A)
None
CA  A9014 (-3.4A)
None
 1.18A 3eeyF-5n8pA:
undetectable		 3eeyF-5n8pA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 7 THR A 729
VAL A 752
THR A 750
VAL A 779
 None
 0.56A 3em0B-5n8pA:
undetectable		 3em0B-5n8pA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 8 GLY A 450
ILE A 481
VAL A 457
VAL A 427
 None
 0.82A 3fi0B-5n8pA:
undetectable		 3fi0B-5n8pA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 8 GLY A 450
ILE A 481
VAL A 457
VAL A 427
 None
 0.76A 3fi0G-5n8pA:
undetectable		 3fi0G-5n8pA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 8 GLY A 450
ILE A 481
VAL A 457
VAL A 427
 None
 0.78A 3fi0Q-5n8pA:
undetectable		 3fi0Q-5n8pA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 4 GLY A 863
VAL A 846
GLY A 817
THR A 792
 CA  A9011 ( 4.7A)
None
None
None
 0.95A 3ib2A-5n8pA:
undetectable		 3ib2A-5n8pA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 7 LEU A 621
LEU A 590
SER A 593
THR A 542
 None
 0.83A 3lm8B-5n8pA:
undetectable
3lm8D-5n8pA:
undetectable		 3lm8B-5n8pA:
10.43
3lm8D-5n8pA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		3 / 3 ASP A 556
ARG A 529
ALA A 559
 None
 0.80A 3mbgC-5n8pA:
undetectable		 3mbgC-5n8pA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 4 GLY A 727
GLY A 748
THR A 750
LEU A 722
 None
 0.94A 3si7C-5n8pA:
undetectable
3si7D-5n8pA:
undetectable		 3si7C-5n8pA:
13.61
3si7D-5n8pA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ASN A 788
GLY A 739
ALA A 782
GLY A 783
GLN A 806
 None
None
None
CA  A9009 ( 3.7A)
None
 0.86A 3v3oA-5n8pA:
undetectable		 3v3oA-5n8pA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 6 THR A 264
ASN A 266
ASP A 294
ILE A 316
 None
None
CA  A9002 ( 2.5A)
None
 1.21A 3w9tB-5n8pA:
undetectable		 3w9tB-5n8pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 10 ALA A 924
ILE A 921
ILE A 909
LEU A 932
ILE A1005
 None
 1.31A 4dtaA-5n8pA:
undetectable		 4dtaA-5n8pA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 VAL A 988
LEU A1007
PHE A 979
LEU A 958
VAL A1004
 None
 1.06A 4eckB-5n8pA:
undetectable		 4eckB-5n8pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 5 SER A 850
GLY A 872
THR A 854
ASP A 878
 None
CA  A9014 ( 4.9A)
None
CA  A9014 (-3.4A)
 1.07A 4eohA-5n8pA:
undetectable		 4eohA-5n8pA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 11 VAL A 408
ALA A 409
SER A 412
SER A 411
THR A 392
 None
 1.23A 4mmaA-5n8pA:
undetectable		 4mmaA-5n8pA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 GLY A 355
GLY A 377
ILE A 313
THR A 312
GLY A 337
 None
 1.18A 4n48B-5n8pA:
undetectable		 4n48B-5n8pA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 587
LEU A 582
ILE A 592
LEU A 621
ILE A 611
 None
 1.10A 4nx6A-5n8pA:
undetectable		 4nx6A-5n8pA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 587
LEU A 582
ILE A 592
LEU A 621
ILE A 611
 None
 1.08A 4nx7A-5n8pA:
undetectable		 4nx7A-5n8pA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 7 SER A 915
GLY A1000
ALA A1001
SER A 974
 None
 0.81A 4r1zB-5n8pA:
undetectable		 4r1zB-5n8pA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 THR A 574
ILE A 570
ASN A 546
VAL A 598
ILE A 600
 None
 1.07A 4rvgA-5n8pA:
undetectable		 4rvgA-5n8pA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 930
THR A 985
VAL A 989
ALA A 976
ILE A1005
 None
 0.97A 4x1yD-5n8pA:
undetectable		 4x1yD-5n8pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 930
THR A 985
VAL A 989
ALA A 976
ILE A1005
 None
 0.98A 4x20B-5n8pA:
undetectable		 4x20B-5n8pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 7 VAL A 335
THR A 331
LEU A 296
VAL A 321
 None
 0.82A 5e4dA-5n8pA:
undetectable
5e4dB-5n8pA:
undetectable		 5e4dA-5n8pA:
11.66
5e4dB-5n8pA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 10 LEU A1007
ASP A 896
ILE A 880
ILE A 906
ILE A 921
 None
CA  A9014 (-2.3A)
None
None
None
 1.07A 5kr1A-5n8pA:
undetectable		 5kr1A-5n8pA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 11 SER A 844
THR A 767
THR A 816
SER A 769
ALA A 819
 None
 1.39A 5l5fV-5n8pA:
undetectable
5l5fb-5n8pA:
undetectable		 5l5fV-5n8pA:
12.68
5l5fb-5n8pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 11 SER A 844
THR A 767
THR A 816
SER A 769
ALA A 819
 None
 1.38A 5l5fH-5n8pA:
undetectable
5l5fN-5n8pA:
undetectable		 5l5fH-5n8pA:
12.68
5l5fN-5n8pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		3 / 3 GLY A 424
THR A 422
ASN A 451
 None
 0.69A 5odiG-5n8pA:
undetectable		 5odiG-5n8pA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		3 / 3 GLY A 473
THR A 439
ASN A 435
 None
 0.70A 5odiG-5n8pA:
undetectable		 5odiG-5n8pA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 SER A 661
GLY A 705
ALA A 704
SER A 687
GLU A 624
 None
 1.46A 5wbvA-5n8pA:
undetectable		 5wbvA-5n8pA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 10 GLY A 528
GLY A 530
SER A 557
GLU A 558
ASP A 562
 None
CA  A9016 ( 4.6A)
None
CA  A9016 (-2.1A)
CA  A9004 ( 2.2A)
 1.14A 6exiA-5n8pA:
2.5		 6exiA-5n8pA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 10 GLY A 528
GLY A 530
SER A 557
GLU A 558
ASP A 562
 None
CA  A9016 ( 4.6A)
None
CA  A9016 (-2.1A)
CA  A9004 ( 2.2A)
 1.15A 6exiB-5n8pA:
2.6		 6exiB-5n8pA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 GLY A 528
GLY A 530
SER A 557
GLU A 558
ASP A 562
 None
CA  A9016 ( 4.6A)
None
CA  A9016 (-2.1A)
CA  A9004 ( 2.2A)
 1.14A 6exiC-5n8pA:
2.5
6exiD-5n8pA:
2.4		 6exiC-5n8pA:
5.77
6exiD-5n8pA:
5.77