SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 11 GLY A 433
ILE A 394
ASP A 365
GLY A 325
LEU A 313
None
1.12A 1jg3A-5n9jA:
undetectable
1jg3A-5n9jA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 11 GLY A 433
ILE A 394
ASP A 365
GLY A 325
LEU A 313
None
1.10A 1jg3B-5n9jA:
undetectable
1jg3B-5n9jA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 7 GLN A 479
GLU A 482
PHE W 441
ALA A 441
None
1.02A 1linA-5n9jA:
undetectable
1linA-5n9jA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
5 / 9 LEU W 305
ILE W 310
GLY W 235
CYH W 401
PHE W 397
None
1.31A 1td7A-5n9jW:
undetectable
1td7A-5n9jW:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10

(Schizosaccharomy
ces
pombe)
5 / 11 LEU B  48
LEU B  28
PHE B  25
LEU B  55
ASP B  54
None
1.27A 2q6hA-5n9jB:
undetectable
2q6hA-5n9jB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10

(Schizosaccharomy
ces
pombe)
5 / 11 LEU B  48
LEU B  28
PHE B  25
LEU B  55
ASP B  54
None
1.26A 2qeiA-5n9jB:
undetectable
2qeiA-5n9jB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 19

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
3 / 3 PRO C  17
GLY B 137
TYR C  15
None
0.68A 2vouA-5n9jC:
undetectable
2vouA-5n9jC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
4 / 6 GLN A 485
PHE A 556
LEU A 551
PHE A 420
None
1.11A 3ablP-5n9jA:
2.8
3ablW-5n9jA:
undetectable
3ablP-5n9jA:
18.62
3ablW-5n9jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 4 ILE A 184
GLN A 206
ILE A 167
LEU W  51
None
1.26A 3dzyD-5n9jA:
undetectable
3dzyD-5n9jA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 4 ILE W 450
GLN W 442
ILE W 493
LEU W 439
None
1.24A 3dzyD-5n9jW:
undetectable
3dzyD-5n9jW:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10

(Schizosaccharomy
ces
pombe)
5 / 12 LEU B  48
LEU B  28
PHE B  25
LEU B  55
ASP B  54
None
1.35A 3gwuA-5n9jB:
3.0
3gwuA-5n9jB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 12 THR B  22
THR B  21
GLU B  19
LEU A  64
LEU B  51
None
1.39A 3gwxB-5n9jB:
undetectable
3gwxB-5n9jB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gB-5n9jA:
undetectable
3j6gB-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gD-5n9jA:
undetectable
3j6gD-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gF-5n9jA:
undetectable
3j6gF-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gH-5n9jA:
undetectable
3j6gH-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gJ-5n9jA:
undetectable
3j6gJ-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gL-5n9jA:
undetectable
3j6gL-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gN-5n9jA:
undetectable
3j6gN-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gP-5n9jA:
undetectable
3j6gP-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
None
1.44A 3j6gR-5n9jA:
undetectable
3j6gR-5n9jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 8 GLU A 482
ASN W 518
ASN W 525
ILE A 553
None
1.16A 3kp6A-5n9jA:
undetectable
3kp6B-5n9jA:
undetectable
3kp6A-5n9jA:
14.39
3kp6B-5n9jA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
4 / 5 LEU A 307
GLN A 281
THR A 282
HIS A 329
None
1.45A 3n58C-5n9jA:
undetectable
3n58C-5n9jA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
5 / 11 ILE A 165
ALA A 185
ILE W  41
LEU A 161
THR A 190
None
1.27A 3qg2B-5n9jA:
undetectable
3qg2B-5n9jA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 6 GLN W 302
ASP W 309
GLU A 288
LEU W 301
None
1.36A 4ax8A-5n9jW:
undetectable
4ax8A-5n9jW:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
4 / 7 VAL A 428
VAL A 426
LEU A 415
ASN A 460
None
1.12A 4e1gB-5n9jA:
1.3
4e1gB-5n9jA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A 329
TRP A 362
LEU A 393
ASP A 365
GLY A 325
None
1.27A 4fogA-5n9jA:
undetectable
4fogA-5n9jA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A 329
TRP A 362
LEU A 393
ASP A 365
GLY A 325
None
1.34A 4fogC-5n9jA:
undetectable
4fogC-5n9jA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 19

(Schizosaccharomy
ces
pombe)
4 / 7 THR C  33
ASN B  98
GLN A  90
LEU A  87
None
0.75A 4ib4A-5n9jC:
undetectable
4ib4A-5n9jC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 19

(Schizosaccharomy
ces
pombe)
4 / 6 THR C  33
ASN B  98
GLN A  90
LEU A  87
None
0.74A 4nc3A-5n9jC:
undetectable
4nc3A-5n9jC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
4 / 8 ASN A  43
VAL B  32
LEU B  35
ILE B  44
None
0.57A 4r38A-5n9jA:
undetectable
4r38A-5n9jA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 20

(Schizosaccharomy
ces
pombe)
4 / 7 PRO Y   2
GLU Y 134
ASP W 505
THR W 498
None
1.22A 4uacA-5n9jY:
undetectable
4uacA-5n9jY:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 6 LEU W 478
ILE W 480
LEU W 434
TYR W 431
None
0.96A 4w5nA-5n9jW:
undetectable
4w5nA-5n9jW:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
5n9j MEDIATOR COMPLEX
SUBUNIT 9
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 4

(Schizosaccharomy
ces
pombe)
5 / 9 LEU G  57
GLY G  54
GLU F  67
ILE F  76
VAL F  70
None
1.43A 4x3mA-5n9jG:
undetectable
4x3mA-5n9jG:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 5 GLU W 348
THR W 349
HIS W 400
LEU W 314
None
1.13A 5axaA-5n9jW:
undetectable
5axaA-5n9jW:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 5 GLU W 348
THR W 349
HIS W 400
LEU W 314
None
1.13A 5axaC-5n9jW:
undetectable
5axaC-5n9jW:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
5 / 12 PRO A 443
GLY W 322
GLY W 325
ILE W 429
LEU A 450
None
1.18A 5fa8A-5n9jA:
undetectable
5fa8A-5n9jA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
5 / 12 GLY W 242
LYS W 300
GLN W 302
GLU W 303
LEU W 305
None
1.21A 5nwuA-5n9jW:
undetectable
5nwuA-5n9jW:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 4 LEU W 243
GLY W 242
SER W 257
SER W 258
None
1.24A 5uunA-5n9jW:
undetectable
5uunA-5n9jW:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
4 / 4 LEU W 243
GLY W 242
SER W 257
SER W 258
None
1.35A 5uunB-5n9jW:
undetectable
5uunB-5n9jW:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 4

(Schizosaccharomy
ces
pombe)
4 / 9 ILE G  48
TYR G   3
ILE G   7
LEU G  37
None
0.76A 5vkqB-5n9jG:
3.4
5vkqC-5n9jG:
3.4
5vkqB-5n9jG:
8.84
5vkqC-5n9jG:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
3 / 3 THR W 504
THR W 500
ARG W 477
None
0.90A 5wm2A-5n9jW:
undetectable
5wm2A-5n9jW:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 20

(Schizosaccharomy
ces
pombe)
5 / 9 SER Y 157
PHE Y  17
SER Y  11
SER Y  10
GLY Y 123
None
1.37A 6awpA-5n9jY:
undetectable
6awpA-5n9jY:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 20

(Schizosaccharomy
ces
pombe)
4 / 6 ILE Y  98
LEU Y 181
VAL Y 115
ARG Y 185
None
1.16A 6f6jA-5n9jY:
undetectable
6f6jA-5n9jY:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomy
ces
pombe)
3 / 3 TRP W 311
ILE W 345
GLU W 317
None
0.80A 6hcxA-5n9jW:
undetectable
6hcxA-5n9jW:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
3 / 3 ASN A 245
PRO A 227
GLN A 206
None
0.81A 6jnhA-5n9jA:
undetectable
6jnhA-5n9jA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
3 / 3 ASN A 245
PRO A 227
GLN A 206
None
0.81A 6jogA-5n9jA:
undetectable
6jogA-5n9jA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomy
ces
pombe)
3 / 3 ARG A 168
PHE A 179
PHE A 222
None
1.02A 6nknC-5n9jA:
2.9
6nknJ-5n9jA:
undetectable
6nknC-5n9jA:
18.62
6nknJ-5n9jA:
9.60