SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 9 PHE A 109
VAL A 202
GLY A 165
PHE A 167
GLU A 207
 None
 1.48A 2w98A-5n9uA:
undetectable		 2w98A-5n9uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 8 ASP A 150
ALA A 142
GLY A  99
ILE A 102
 None
 0.83A 3el9A-5n9uA:
undetectable		 3el9A-5n9uA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 GLY A  99
SER A  97
ASP A 150
ILE A 141
LEU A 130
 None
 1.21A 3iv6B-5n9uA:
undetectable		 3iv6B-5n9uA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 GLY A  99
SER A  97
ASP A 150
ILE A 141
LEU A 130
 None
 1.09A 3iv6D-5n9uA:
undetectable		 3iv6D-5n9uA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 6 PHE A  22
ARG A  25
PRO A  61
SER A  73
 GSH  A 301 (-3.0A)
GSH  A 301 ( 4.7A)
GSH  A 301 (-4.0A)
GSH  A 301 (-2.5A)
 0.40A 3vlnA-5n9uA:
19.7		 3vlnA-5n9uA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 11 ILE A 102
ALA A 154
LEU A 153
VAL A 149
LEU A 130
 None
 1.14A 4g1bB-5n9uA:
undetectable		 4g1bB-5n9uA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 10 LEU A 164
LEU A 157
LEU A 127
LEU A 123
PHE A 109
 None
 1.06A 4odoB-5n9uA:
undetectable		 4odoB-5n9uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 7 ASP A 150
THR A 147
VAL A 179
TYR A 182
 None
 1.01A 5ov9A-5n9uA:
undetectable		 5ov9A-5n9uA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 6 LYS A   1
VAL A  70
LYS A  64
ILE A  79
 None
 1.47A 5q1sA-5n9uA:
undetectable		 5q1sA-5n9uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		3 / 3 ASP A  72
PHE A 103
ARG A  25
 GSH  A 301 (-1.7A)
None
GSH  A 301 ( 4.7A)
 1.12A 5yw0A-5n9uA:
undetectable		 5yw0A-5n9uA:
23.81