SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5n9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_2
(DIHYDROFOLATE
REDUCTASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 4 TYR A 166
ARG A 378
VAL A 161
THR A 314
 None
None
None
ATP  A 602 (-3.7A)
 1.34A 1dlsA-5n9xA:
undetectable		 1dlsA-5n9xA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 11 VAL A 116
VAL A  96
TYR A  95
LEU A  60
ILE A  88
 None
 1.36A 1t6zB-5n9xA:
2.5		 1t6zB-5n9xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 6 ALA A 221
TYR A  46
TRP A 219
ILE A 218
 None
 1.11A 2dcfA-5n9xA:
undetectable		 2dcfA-5n9xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 6 ASP A  40
GLU A  42
ARG A 143
MET A  75
 None
 1.21A 2ouzA-5n9xA:
undetectable		 2ouzA-5n9xA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		3 / 3 ARG A 400
THR A 316
VAL A 371
 None
 0.91A 2qakA-5n9xA:
undetectable		 2qakA-5n9xA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 7 ALA A 221
TYR A  46
TRP A 219
ILE A 218
 None
 1.11A 2zm7A-5n9xA:
undetectable		 2zm7A-5n9xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.14A 3eeyA-5n9xA:
2.9		 3eeyA-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.16A 3eeyB-5n9xA:
undetectable		 3eeyB-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.17A 3eeyC-5n9xA:
3.0		 3eeyC-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.13A 3eeyD-5n9xA:
3.0		 3eeyD-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.08A 3eeyH-5n9xA:
2.9		 3eeyH-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.08A 3eeyI-5n9xA:
3.0		 3eeyI-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.16A 3eeyJ-5n9xA:
2.9		 3eeyJ-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		3 / 3 ASP A 406
GLU A 315
SER A 335
 ATP  A 602 (-2.7A)
ATP  A 602 (-3.4A)
ATP  A 602 ( 4.8A)
 0.84A 3p2kA-5n9xA:
undetectable		 3p2kA-5n9xA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PQZ_L_CCSL11_0
(GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 7
CYCLIC PEPTIDE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 4 LEU A 264
TRP A 296
PHE A 283
PRO A 258
 None
 1.39A 3pqzD-5n9xA:
0.0
3pqzL-5n9xA:
undetectable		 3pqzD-5n9xA:
13.96
3pqzL-5n9xA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PQZ_M_CCSM11_0
(GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 7
CYCLIC PEPTIDE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 4 LEU A 264
TRP A 296
PHE A 283
PRO A 258
 None
 1.38A 3pqzC-5n9xA:
0.0
3pqzM-5n9xA:
undetectable		 3pqzC-5n9xA:
13.96
3pqzM-5n9xA:
2.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 7 PHE A 211
ASP A 212
GLY A 284
THR A 314
 THR  A 601 (-4.5A)
THR  A 601 (-2.7A)
THR  A 601 ( 4.1A)
ATP  A 602 (-3.7A)
 0.71A 3vnsA-5n9xA:
59.3		 3vnsA-5n9xA:
56.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		6 / 7 PHE A 211
ASP A 212
PHE A 213
GLY A 285
THR A 314
LYS A 515
 THR  A 601 (-4.5A)
THR  A 601 (-2.7A)
THR  A 601 (-3.5A)
ATP  A 602 ( 3.3A)
ATP  A 602 (-3.7A)
THR  A 601 ( 2.5A)
 0.48A 3vnsA-5n9xA:
59.3		 3vnsA-5n9xA:
56.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 PHE A 261
LEU A 254
VAL A 246
LEU A 264
ILE A 273
 None
 0.89A 4g1bD-5n9xA:
3.1		 4g1bD-5n9xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 6 ARG A 510
ASN A 513
GLY A 312
PRO A 258
 None
None
THR  A 601 ( 3.5A)
None
 1.06A 4l1aB-5n9xA:
undetectable		 4l1aB-5n9xA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 4 ALA A 260
HIS A 207
PHE A 206
LEU A 254
 None
 1.26A 4lufA-5n9xA:
undetectable		 4lufA-5n9xA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 7 PHE A 211
ASP A 212
GLY A 284
THR A 314
 THR  A 601 (-4.5A)
THR  A 601 (-2.7A)
THR  A 601 ( 4.1A)
ATP  A 602 (-3.7A)
 0.84A 4zxiA-5n9xA:
46.2		 4zxiA-5n9xA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 7 PHE A 211
ASP A 212
GLY A 285
THR A 314
LYS A 515
 THR  A 601 (-4.5A)
THR  A 601 (-2.7A)
ATP  A 602 ( 3.3A)
ATP  A 602 (-3.7A)
THR  A 601 ( 2.5A)
 0.49A 4zxiA-5n9xA:
46.2		 4zxiA-5n9xA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 5 ALA A 504
PRO A 499
GLY A 430
LEU A 435
 None
 1.01A 5eslA-5n9xA:
undetectable		 5eslA-5n9xA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 VAL A 111
LEU A  60
ASP A  69
ALA A  72
PRO A 123
 None
 1.33A 5hnzB-5n9xA:
undetectable		 5hnzB-5n9xA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 11 ILE A  39
ILE A  44
VAL A 230
ILE A  82
ALA A  83
 None
 0.92A 5lg3A-5n9xA:
undetectable		 5lg3A-5n9xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 ILE A  39
ILE A  44
VAL A 230
ILE A  82
ALA A  83
 None
 0.98A 5lg3E-5n9xA:
undetectable		 5lg3E-5n9xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 5 LEU A 187
PHE A 195
LEU A 341
TRP A 216
 None
 1.47A 5m10A-5n9xA:
2.7		 5m10A-5n9xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 ILE A 313
TYR A 311
GLY A 312
HIS A 319
PHE A 344
 ATP  A 602 ( 4.3A)
ATP  A 602 (-4.9A)
THR  A 601 ( 3.5A)
THR  A 601 ( 4.8A)
None
 1.22A 5n0wA-5n9xA:
undetectable		 5n0wA-5n9xA:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 7 PHE A 211
ASP A 212
GLY A 284
GLY A 312
 THR  A 601 (-4.5A)
THR  A 601 (-2.7A)
THR  A 601 ( 4.1A)
THR  A 601 ( 3.5A)
 1.00A 5n9xA-5n9xA:
71.2		 5n9xA-5n9xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		7 / 7 PHE A 211
ASP A 212
PHE A 213
GLY A 285
GLY A 312
HIS A 319
LYS A 515
 THR  A 601 (-4.5A)
THR  A 601 (-2.7A)
THR  A 601 (-3.5A)
ATP  A 602 ( 3.3A)
THR  A 601 ( 3.5A)
THR  A 601 ( 4.8A)
THR  A 601 ( 2.5A)
 0.01A 5n9xA-5n9xA:
71.2		 5n9xA-5n9xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 4 ARG A  70
ILE A 164
TYR A 166
ILE A 110
 None
 1.46A 5odhG-5n9xA:
3.9		 5odhG-5n9xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		5 / 12 SER A 114
ILE A 164
ALA A  94
ALA A 118
GLY A 121
 None
 1.00A 5veuA-5n9xA:
undetectable		 5veuA-5n9xA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 5 LEU A  86
THR A  19
PRO A 153
ARG A  66
 None
 1.08A 6ew0B-5n9xA:
undetectable		 6ew0B-5n9xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 5 LEU A  86
THR A  19
PRO A 153
ARG A  66
 None
 1.09A 6ew0D-5n9xA:
undetectable		 6ew0D-5n9xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 5 LEU A  86
THR A  19
PRO A 153
ARG A  66
 None
 1.09A 6ew0F-5n9xA:
undetectable		 6ew0F-5n9xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 5 LEU A  86
THR A  19
PRO A 153
ARG A  66
 None
 1.08A 6ew0H-5n9xA:
undetectable		 6ew0H-5n9xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5n9x ADENYLATION DOMAIN
(Streptomyces
sp.) 		4 / 5 LEU A  86
THR A  19
PRO A 153
ARG A  66
 None
 1.08A 6ew0I-5n9xA:
undetectable		 6ew0I-5n9xA:
9.70