SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5na4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 5 LEU A  37
SER A 268
LEU A 270
GLY A  12
 None
FAD  A1001 ( 4.6A)
None
FAD  A1001 (-3.3A)
 1.11A 1a4lB-5na4A:
undetectable		 1a4lB-5na4A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.04A 1c8lA-5na4A:
undetectable		 1c8lA-5na4A:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.04A 1gfzA-5na4A:
undetectable		 1gfzA-5na4A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 12 LEU A 254
ASN A 255
LEU A 162
GLY A 242
VAL A 236
 None
 1.18A 1gs4A-5na4A:
undetectable		 1gs4A-5na4A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 12 ILE A 283
GLY A 301
VAL A 299
ALA A 319
GLY A 267
 None
FAD  A1001 (-3.3A)
None
FAD  A1001 (-3.7A)
None
 1.15A 1kiaB-5na4A:
3.5		 1kiaB-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.05A 1l5qA-5na4A:
undetectable		 1l5qA-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.08A 1l5qB-5na4A:
undetectable		 1l5qB-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.04A 1l7xA-5na4A:
undetectable		 1l7xA-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.07A 1l7xB-5na4A:
undetectable		 1l7xB-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 12 GLY A 400
ILE A 390
GLY A 391
GLY A 392
ILE A 393
 None
 0.74A 2avvA-5na4A:
undetectable		 2avvA-5na4A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		6 / 12 GLY A 110
GLY A 326
GLY A  17
GLY A  14
THR A  20
LEU A  24
 FAD  A1001 (-3.1A)
None
None
FAD  A1001 (-3.3A)
None
None
 1.34A 2oxtB-5na4A:
2.9		 2oxtB-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.06A 3dd1A-5na4A:
2.8		 3dd1A-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.02A 3dd1B-5na4A:
undetectable		 3dd1B-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.06A 3ddsA-5na4A:
undetectable		 3ddsA-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.05A 3ddsB-5na4A:
undetectable		 3ddsB-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.05A 3ddwA-5na4A:
undetectable		 3ddwA-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 145
ALA A 149
GLY A 189
TYR A 188
 None
 1.04A 3ddwB-5na4A:
undetectable		 3ddwB-5na4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		3 / 3 VAL A  76
LYS A  73
HIS A  44
 None
 0.91A 3elzA-5na4A:
undetectable		 3elzA-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 12 ALA A 262
LEU A 174
PHE A 173
THR A 258
ILE A 161
 None
 1.22A 3hj3A-5na4A:
undetectable		 3hj3A-5na4A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 12 LEU A 222
CYH A 199
VAL A 163
GLY A 164
ILE A 128
 None
None
None
None
FAD  A1001 ( 4.8A)
 1.08A 3ijdB-5na4A:
undetectable		 3ijdB-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 6 PHE A 306
LEU A 315
PRO A 314
GLU A 311
 None
 1.27A 3vlnA-5na4A:
undetectable		 3vlnA-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 12 GLU A  94
VAL A  79
ILE A  38
ILE A  99
TYR A 100
 None
 1.33A 4a99A-5na4A:
11.5
4a99C-5na4A:
11.5		 4a99A-5na4A:
13.51
4a99C-5na4A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 11 GLY A 357
ASP A 360
GLY A 361
VAL A 171
HIS A 217
 None
 1.22A 4c5lA-5na4A:
2.8		 4c5lA-5na4A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 10 GLY A 357
ASP A 360
GLY A 361
VAL A 171
HIS A 217
 None
 1.15A 4c5lC-5na4A:
undetectable		 4c5lC-5na4A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 10 GLY A 357
ASP A 360
GLY A 361
VAL A 171
HIS A 217
 None
 1.16A 4c5lD-5na4A:
2.0		 4c5lD-5na4A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 10 GLY A 357
ASP A 360
GLY A 361
VAL A 171
HIS A 217
 None
 1.27A 4c5nD-5na4A:
undetectable		 4c5nD-5na4A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 12 LEU A 184
GLY A 175
LEU A 174
VAL A 163
VAL A 195
 None
 1.20A 4wnwA-5na4A:
undetectable		 4wnwA-5na4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 10 GLY A 361
VAL A 362
THR A 352
MET A 209
LEU A 207
 None
None
FAD  A1001 ( 4.8A)
None
None
 1.32A 4yb6C-5na4A:
undetectable
4yb6F-5na4A:
undetectable		 4yb6C-5na4A:
undetectable
4yb6F-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 10 MET A 209
LEU A 207
GLY A 361
VAL A 362
THR A 352
 None
None
None
None
FAD  A1001 ( 4.8A)
 1.30A 4yb6A-5na4A:
undetectable
4yb6D-5na4A:
undetectable		 4yb6A-5na4A:
undetectable
4yb6D-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		5 / 10 MET A 209
LEU A 207
GLY A 361
VAL A 362
THR A 352
 None
None
None
None
FAD  A1001 ( 4.8A)
 1.31A 4yb6D-5na4A:
undetectable
4yb6E-5na4A:
undetectable		 4yb6D-5na4A:
undetectable
4yb6E-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878
(Staphylococcus
aureus) 		4 / 5 ASN A 157
VAL A 227
LEU A 174
SER A 259
 None
 1.04A 6a7pA-5na4A:
undetectable		 6a7pA-5na4A:
undetectable