SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 PHE A 131
PHE A  36
ILE A 163
GLN A  32
ALA A 127
 None
 1.00A 1fm4A-5nagA:
undetectable		 1fm4A-5nagA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 GLU A 425
SER A 375
GLU A 372
GLU A 368
 None
 1.08A 1knyA-5nagA:
undetectable
1knyB-5nagA:
undetectable		 1knyA-5nagA:
19.03
1knyB-5nagA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 TYR A 382
SER A 375
HIS A 240
HIS A 191
 None
 1.30A 1s19A-5nagA:
undetectable		 1s19A-5nagA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 334
ILE A  13
GLY A 164
GLY A 310
LEU A 145
 None
FAD  A 501 (-4.6A)
None
FAD  A 501 (-3.4A)
None
 1.09A 1vptA-5nagA:
undetectable		 1vptA-5nagA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.20A 1ya3A-5nagA:
undetectable		 1ya3A-5nagA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.23A 2aa5A-5nagA:
undetectable		 2aa5A-5nagA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.23A 2aa6A-5nagA:
undetectable		 2aa6A-5nagA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 7 HIS A 337
ASN A 344
ASP A 343
THR A 352
 None
 0.95A 2f6dA-5nagA:
undetectable		 2f6dA-5nagA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		3 / 3 ASP A 139
ARG A 144
ARG A 142
 None
 0.88A 2j9dA-5nagA:
undetectable
2j9dC-5nagA:
undetectable		 2j9dA-5nagA:
11.98
2j9dC-5nagA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.27A 2oaxD-5nagA:
undetectable		 2oaxD-5nagA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A  53
ARG A 111
TYR A 193
ASP A 311
 FAD  A 501 (-3.9A)
FAD  A 501 (-2.8A)
8R5  A 502 (-3.9A)
FAD  A 501 (-2.8A)
 1.11A 2qebA-5nagA:
undetectable		 2qebA-5nagA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A  53
ARG A 111
TYR A 193
ASP A 311
 FAD  A 501 (-3.9A)
FAD  A 501 (-2.8A)
8R5  A 502 (-3.9A)
FAD  A 501 (-2.8A)
 1.14A 2qebB-5nagA:
undetectable		 2qebB-5nagA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 PHE A 319
PHE A 266
ALA A 262
GLY A 192
GLN A 189
 8R5  A 502 (-4.9A)
None
None
None
None
 1.24A 2ve3B-5nagA:
undetectable		 2ve3B-5nagA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASP A 181
GLY A 183
LEU A 297
ALA A 177
SER A 178
 None
 1.23A 3d91B-5nagA:
undetectable		 3d91B-5nagA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		3 / 3 GLU A 449
VAL A 450
CYH A 453
 None
 0.95A 3fbxA-5nagA:
undetectable		 3fbxA-5nagA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A 366
ASN A 325
ALA A  58
ILE A 106
LEU A 213
 None
FAD  A 501 (-3.9A)
None
None
8R5  A 502 ( 4.6A)
 1.05A 3fl9F-5nagA:
undetectable		 3fl9F-5nagA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		3 / 3 HIS A  87
HIS A 214
MET A  85
 None
 0.81A 3mihA-5nagA:
undetectable		 3mihA-5nagA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 9 ALA A 312
ASP A 311
GLY A  19
ILE A  12
LEU A 135
 None
FAD  A 501 (-2.8A)
None
None
FAD  A 501 (-4.8A)
 1.12A 3u7sB-5nagA:
undetectable		 3u7sB-5nagA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 9 ALA A 312
ASP A 311
GLY A  19
ILE A  12
LEU A 135
 None
FAD  A 501 (-2.8A)
None
None
FAD  A 501 (-4.8A)
 1.07A 3u7sA-5nagA:
undetectable		 3u7sA-5nagA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 11 ALA A 331
LEU A  25
LEU A  26
GLY A 121
LEU A 118
 None
 1.24A 3uudA-5nagA:
undetectable		 3uudA-5nagA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 ARG A  43
GLU A  73
LEU A  70
ASP A 120
 None
 1.37A 4cevA-5nagA:
undetectable
4cevB-5nagA:
undetectable		 4cevA-5nagA:
22.51
4cevB-5nagA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 ASP A 120
ARG A  43
GLU A  73
LEU A  70
 None
 1.35A 4cevA-5nagA:
undetectable
4cevC-5nagA:
undetectable		 4cevA-5nagA:
22.51
4cevC-5nagA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 ARG A  43
GLU A  73
LEU A  70
ASP A 120
 None
 1.35A 4cevD-5nagA:
undetectable
4cevE-5nagA:
undetectable		 4cevD-5nagA:
22.51
4cevE-5nagA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 ARG A  43
GLU A  73
LEU A  70
ASP A 120
 None
 1.35A 4cevE-5nagA:
undetectable
4cevF-5nagA:
undetectable		 4cevE-5nagA:
22.51
4cevF-5nagA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  19
ALA A  23
ALA A 335
ASP A 330
ALA A 327
 None
None
None
None
FAD  A 501 (-3.6A)
 1.20A 4df3A-5nagA:
2.7		 4df3A-5nagA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  19
ALA A  23
ALA A 335
ASP A 330
ALA A 327
 None
None
None
None
FAD  A 501 (-3.6A)
 1.28A 4df3B-5nagA:
2.6		 4df3B-5nagA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 10 ARG A  66
ALA A  62
LEU A  65
GLY A  69
ALA A 312
 None
 1.36A 4fe1A-5nagA:
undetectable
4fe1J-5nagA:
undetectable		 4fe1A-5nagA:
20.98
4fe1J-5nagA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		3 / 3 GLN A 356
THR A 298
THR A 299
 None
 0.82A 4fu9A-5nagA:
undetectable		 4fu9A-5nagA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 11 SER A 170
GLY A 167
ALA A  18
GLY A  14
ALA A   7
 None
FAD  A 501 (-3.7A)
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
 1.20A 4l6v1-5nagA:
undetectable
4l6v6-5nagA:
undetectable		 4l6v1-5nagA:
20.53
4l6v6-5nagA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 7 LEU A 114
ASN A 115
LEU A  21
ILE A 129
 None
 0.87A 4ojbA-5nagA:
undetectable		 4ojbA-5nagA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 PHE A 238
ILE A 224
GLY A 321
ILE A 106
 8R5  A 502 (-4.2A)
8R5  A 502 (-4.6A)
8R5  A 502 ( 3.3A)
None
 0.70A 4qogA-5nagA:
undetectable
4qogB-5nagA:
undetectable		 4qogA-5nagA:
19.96
4qogB-5nagA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		3 / 3 GLN A   9
HIS A 160
ARG A 158
 None
 1.25A 4qyqA-5nagA:
undetectable		 4qyqA-5nagA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 7 SER A 103
ARG A  60
GLY A  61
GLU A 329
 None
 1.08A 5btfA-5nagA:
undetectable
5btfC-5nagA:
undetectable
5btfD-5nagA:
undetectable		 5btfA-5nagA:
23.42
5btfC-5nagA:
23.42
5btfD-5nagA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 PHE A 253
PHE A 265
PHE A 270
VAL A 235
PHE A 266
 None
 1.30A 6ap6A-5nagA:
undetectable		 6ap6A-5nagA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 PHE A 253
PHE A 265
PHE A 270
VAL A 235
PHE A 266
 None
 1.29A 6ap6B-5nagA:
undetectable		 6ap6B-5nagA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 309
GLY A 310
VAL A 407
CYH A 326
ILE A 362
 None
FAD  A 501 (-3.4A)
None
None
None
 1.34A 6bxnB-5nagA:
1.8		 6bxnB-5nagA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A 177
VAL A  10
VAL A  22
LEU A 297
ALA A 313
 None
 0.94A 6djzC-5nagA:
undetectable		 6djzC-5nagA:
20.40