SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		4 / 5 VAL A 216
SER A 236
VAL A 240
SER A 195
 None
 1.28A 2j9cA-5nc6A:
undetectable
2j9cB-5nc6A:
undetectable
2j9cC-5nc6A:
undetectable		 2j9cA-5nc6A:
undetectable
2j9cB-5nc6A:
undetectable
2j9cC-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		4 / 8 ARG A 272
MET A 273
GLY A 185
GLY A 176
 None
 0.93A 2y6rB-5nc6A:
undetectable		 2y6rB-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		4 / 6 ASP A  76
LEU A 101
LEU A  90
HIS A 121
 ACT  A 301 ( 3.5A)
None
None
None
 1.27A 3bj8C-5nc6A:
undetectable
3bj8D-5nc6A:
undetectable		 3bj8C-5nc6A:
23.29
3bj8D-5nc6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		3 / 3 HIS A 230
HIS A 233
ILE A 232
 ACT  A 301 (-4.2A)
None
None
 0.85A 3u52A-5nc6A:
undetectable
3u52C-5nc6A:
undetectable		 3u52A-5nc6A:
undetectable
3u52C-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		5 / 6 ASP A  76
ASP A  77
HIS A 126
HIS A 130
HIS A 230
 ACT  A 301 ( 3.5A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ACT  A 301 (-4.2A)
 0.23A 5ncdA-5nc6A:
39.2
5ncdD-5nc6A:
38.3		 5ncdA-5nc6A:
undetectable
5ncdD-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		5 / 6 ASP A  76
ASP A  77
HIS A 126
HIS A 130
HIS A 230
 ACT  A 301 ( 3.5A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ACT  A 301 (-4.2A)
 0.20A 5ncdB-5nc6A:
38.2
5ncdC-5nc6A:
39.2		 5ncdB-5nc6A:
undetectable
5ncdC-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		4 / 4 ASP A  76
HIS A 126
HIS A 130
HIS A 230
 ACT  A 301 ( 3.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ACT  A 301 (-4.2A)
 0.26A 5ncdD-5nc6A:
38.3		 5ncdD-5nc6A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		6 / 8 ASP A  76
ASP A  77
HIS A 126
HIS A 130
PRO A 166
HIS A 230
 ACT  A 301 ( 3.5A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ACT  A 301 (-4.6A)
ACT  A 301 (-4.2A)
 0.36A 5nekB-5nc6A:
38.0		 5nekB-5nc6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		6 / 8 ASP A  76
ASP A  77
HIS A 126
HIS A 130
TRP A 191
HIS A 230
 ACT  A 301 ( 3.5A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
None
ACT  A 301 (-4.2A)
 0.35A 5nekD-5nc6A:
38.1		 5nekD-5nc6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		5 / 6 ASP A  76
ASP A  77
HIS A 126
HIS A 130
HIS A 230
 ACT  A 301 ( 3.5A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ACT  A 301 (-4.2A)
 0.15A 5nelA-5nc6A:
39.3
5nelD-5nc6A:
38.1		 5nelA-5nc6A:
undetectable
5nelD-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		5 / 6 ASP A  76
HIS A 126
HIS A 130
LEU A 228
HIS A 230
 ACT  A 301 ( 3.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
None
ACT  A 301 (-4.2A)
 0.13A 5nelB-5nc6A:
37.9
5nelC-5nc6A:
38.9		 5nelB-5nc6A:
undetectable
5nelC-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		3 / 3 HIS A 230
ASP A  77
HIS A 126
 ACT  A 301 (-4.2A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
 0.76A 5oexB-5nc6A:
undetectable		 5oexB-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		3 / 3 HIS A 230
ASP A  77
HIS A 126
 ACT  A 301 (-4.2A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
 0.76A 5oexC-5nc6A:
undetectable		 5oexC-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Bacillus
cereus) 		3 / 3 HIS A 230
ASP A  77
HIS A 126
 ACT  A 301 (-4.2A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
 0.75A 5oexD-5nc6A:
undetectable		 5oexD-5nc6A:
undetectable