SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5nc8 POTASSIUM EFFLUX
SYSTEM PROTEIN
(Shewanella
denitrificans) 		5 / 12 ILE A 500
ALA A 502
ALA A 412
LEU A 474
LEU A 463
 None
 1.04A 3uvvA-5nc8A:
undetectable		 3uvvA-5nc8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5nc8 POTASSIUM EFFLUX
SYSTEM PROTEIN
(Shewanella
denitrificans) 		3 / 4 SER A 440
GLY A 418
GLU A 524
 None
 0.58A 4juoA-5nc8A:
undetectable
4juoC-5nc8A:
undetectable		 4juoA-5nc8A:
20.67
4juoC-5nc8A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5nc8 POTASSIUM EFFLUX
SYSTEM PROTEIN
(Shewanella
denitrificans) 		5 / 12 GLY A 413
GLY A 415
ASP A 456
ALA A 457
ILE A 487
 AMP  A2401 ( 3.8A)
AMP  A2401 (-3.3A)
AMP  A2401 (-3.4A)
AMP  A2401 (-3.4A)
None
 1.10A 4krhA-5nc8A:
4.4		 4krhA-5nc8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5nc8 POTASSIUM EFFLUX
SYSTEM PROTEIN
(Shewanella
denitrificans) 		4 / 6 ASN A 450
ILE A 410
ILE A 411
VAL A 475
 None
 1.01A 4olmA-5nc8A:
undetectable		 4olmA-5nc8A:
18.53