SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		5 / 12 SER A 212
VAL A 144
LEU A 223
ASN A  97
PHE A 146
 AKG  A 302 (-2.6A)
AKG  A 302 (-4.3A)
AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
 1.39A 1a27A-5nciA:
undetectable		 1a27A-5nciA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		5 / 12 LEU A 223
ASN A  97
LEU A  58
ALA A  57
ARG A  64
 AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
None
None
 1.39A 1ya3A-5nciA:
undetectable		 1ya3A-5nciA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		5 / 12 LEU A 223
ASN A  97
LEU A  58
ALA A  57
ARG A  64
 AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
None
None
 1.38A 2aa5B-5nciA:
undetectable		 2aa5B-5nciA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 PRO A 123
ALA A 124
ASP A 250
ASP A 230
 None
 1.14A 2nyuB-5nciA:
undetectable		 2nyuB-5nciA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		5 / 12 LEU A 223
ASN A  97
LEU A  58
ALA A  57
ARG A  64
 AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
None
None
 1.28A 2oaxD-5nciA:
undetectable		 2oaxD-5nciA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		5 / 12 LEU A 223
ASN A  97
LEU A  58
ALA A  57
ARG A  64
 AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
None
None
 1.32A 2oaxE-5nciA:
undetectable		 2oaxE-5nciA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.25A 2zj0A-5nciA:
undetectable		 2zj0A-5nciA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.26A 3ce6A-5nciA:
undetectable		 3ce6A-5nciA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.27A 3ce6C-5nciA:
undetectable		 3ce6C-5nciA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		3 / 3 VAL A 137
LYS A 195
HIS A 210
 None
None
CO  A 301 ( 3.2A)
 0.83A 3elzA-5nciA:
undetectable		 3elzA-5nciA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
HIS A 205
 None
 1.36A 3g1uC-5nciA:
undetectable		 3g1uC-5nciA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 8 GLY A 259
GLU A  27
LEU A  71
VAL A  67
 None
 0.87A 4fgzB-5nciA:
undetectable		 4fgzB-5nciA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 7 VAL A  30
MET A  31
ALA A  34
PHE A  68
 None
 1.03A 4lb2A-5nciA:
undetectable		 4lb2A-5nciA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.10A 4lvcA-5nciA:
undetectable		 4lvcA-5nciA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.12A 4lvcC-5nciA:
undetectable		 4lvcC-5nciA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		3 / 3 GLY A 259
PRO A 260
GLN A  70
 None
 0.57A 4oltB-5nciA:
undetectable		 4oltB-5nciA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		3 / 3 GLY A 259
PRO A 260
GLN A  70
 None
 0.50A 4qwpB-5nciA:
undetectable		 4qwpB-5nciA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		5 / 12 TRP A 116
TYR A 228
VAL A 128
ASN A  97
ILE A 226
 LEU  A 303 (-3.4A)
None
None
AKG  A 302 (-3.3A)
None
 1.24A 4xe0A-5nciA:
undetectable		 4xe0A-5nciA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 ARG A  56
ALA A  57
TYR A  59
ILE A 225
 None
None
LEU  A 303 (-4.6A)
None
 1.23A 6f6sA-5nciA:
undetectable
6f6sB-5nciA:
undetectable		 6f6sA-5nciA:
14.96
6f6sB-5nciA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.05A 6gbnA-5nciA:
undetectable		 6gbnA-5nciA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 5nci LEUCINE HYDROXYLASE
(Streptomyces
muensis) 		4 / 5 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.04A 6gbnD-5nciA:
undetectable		 6gbnD-5nciA:
20.40