SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 12 GLY A 133
GLY A 235
GLY A 234
GLY A 158
ASN A  79
 None
 0.96A 1n2xB-5nckA:
undetectable		 1n2xB-5nckA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 9 GLY A 114
ALA A 112
LEU A 113
PHE A 127
LEU A 146
 None
 1.37A 1y7iA-5nckA:
undetectable		 1y7iA-5nckA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 7 ILE A 248
ARG A 247
PHE A 194
GLU A 197
 None
 1.09A 2qebA-5nckA:
undetectable		 2qebA-5nckA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 7 ILE A 248
ARG A 247
PHE A 194
GLU A 197
 None
 1.12A 2qebB-5nckA:
undetectable		 2qebB-5nckA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 8 PHE A 226
ILE A 222
GLY A 138
ILE A 136
 None
 0.79A 2qwxA-5nckA:
undetectable
2qwxB-5nckA:
undetectable		 2qwxA-5nckA:
20.54
2qwxB-5nckA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 11 ASN A  39
LEU A  42
LEU A  90
VAL A  62
ILE A  82
 None
 1.25A 3jw5A-5nckA:
undetectable		 3jw5A-5nckA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 7 GLY A 137
PHE A 157
PHE A 147
PHE A 226
 None
 1.14A 3ko0D-5nckA:
undetectable
3ko0E-5nckA:
undetectable		 3ko0D-5nckA:
15.82
3ko0E-5nckA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 11 ILE A 222
ILE A 140
PHE A 226
ILE A 160
GLU A 156
 None
 1.09A 3tmzA-5nckA:
undetectable		 3tmzA-5nckA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		3 / 3 SER A 220
PHE A 260
LYS A 261
 None
 0.94A 3u88A-5nckA:
undetectable		 3u88A-5nckA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A  17
ILE A  13
ILE A  48
ILE A 102
LEU A  90
 None
 1.25A 3w67D-5nckA:
undetectable		 3w67D-5nckA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 9 ILE A 132
LEU A 233
ILE A 231
ILE A 232
ILE A 128
 None
 1.01A 3zosA-5nckA:
undetectable		 3zosA-5nckA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 7 PHE A 194
VAL A 237
ILE A 132
GLU A 197
 None
 1.09A 4a97E-5nckA:
undetectable		 4a97E-5nckA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 8 GLY A  10
ILE A   8
ILE A  82
THR A  32
 None
 0.73A 4em2A-5nckA:
undetectable		 4em2A-5nckA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 7 GLY A 137
GLY A 138
ASN A 109
GLU A 168
 None
 1.08A 4fgkB-5nckA:
undetectable		 4fgkB-5nckA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 5 GLY A 137
GLY A 138
ASN A 109
GLU A 168
 None
 1.21A 4fglC-5nckA:
undetectable		 4fglC-5nckA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 12 GLY A 276
GLY A 279
ILE A  13
THR A  32
GLY A  64
 None
 1.06A 4n48A-5nckA:
undetectable		 4n48A-5nckA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 12 GLY A 276
GLY A 279
ILE A  13
THR A  32
GLY A  64
 None
 1.05A 4n48B-5nckA:
undetectable		 4n48B-5nckA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 8 PHE A 226
ILE A 222
GLY A 138
ILE A 136
 None
 0.84A 4qogA-5nckA:
undetectable
4qogB-5nckA:
undetectable		 4qogA-5nckA:
20.54
4qogB-5nckA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A   4
ASP A  21
PHE A  20
ASN A   2
VAL A  58
 None
 1.46A 5d0yA-5nckA:
undetectable		 5d0yA-5nckA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 7 THR A 173
GLN A 240
ILE A 238
GLY A 236
 None
 1.01A 5nzyA-5nckA:
undetectable		 5nzyA-5nckA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 12 ILE A 245
ILE A 212
LEU A 219
THR A 216
LEU A 252
 None
 1.24A 5tiwA-5nckA:
undetectable		 5tiwA-5nckA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		4 / 9 TYR A 204
ILE A 208
ILE A 212
LEU A 215
 None
 0.52A 5vkqB-5nckA:
undetectable
5vkqC-5nckA:
undetectable		 5vkqB-5nckA:
10.97
5vkqC-5nckA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 12 LEU A 146
GLY A 279
GLY A 114
GLY A 119
ASN A 126
 None
 1.06A 6ce2B-5nckA:
undetectable		 6ce2B-5nckA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5nck N-ACETYLMANNOSAMINE
KINASE
(Fusobacterium
nucleatum) 		5 / 9 ILE A  45
ILE A  41
GLU A  95
VAL A  62
ILE A   8
 None
 1.45A 6hloA-5nckA:
undetectable		 6hloA-5nckA:
20.16