SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ncr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5ncr TYROSINE PHOSPHATASE
(Orf
virus) 		5 / 11 LEU A  97
VAL A 110
TYR A 126
PRO A 107
LEU A 101
 None
 1.45A 1klmA-5ncrA:
undetectable		 1klmA-5ncrA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5ncr TYROSINE PHOSPHATASE
(Orf
virus) 		4 / 5 ALA A 114
LEU A  37
GLY A 120
THR A  16
 PO4  A 200 (-3.5A)
None
None
None
 0.95A 3dl9A-5ncrA:
undetectable		 3dl9A-5ncrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ncr TYROSINE PHOSPHATASE
(Orf
virus) 		3 / 3 ASP A  81
LEU A  37
ARG A 158
 PO4  A 200 (-3.8A)
None
None
 0.85A 5e8qA-5ncrA:
undetectable		 5e8qA-5ncrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5ncr TYROSINE PHOSPHATASE
(Orf
virus) 		4 / 7 LEU A  37
VAL A  35
GLU A 102
ILE A  77
 None
 1.10A 5jh7C-5ncrA:
undetectable		 5jh7C-5ncrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5ncr TYROSINE PHOSPHATASE
(Orf
virus) 		5 / 12 PHE A 161
PHE A 175
MET A 174
THR A 150
TYR A 146
 None
 1.38A 5nknA-5ncrA:
undetectable		 5nknA-5ncrA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5ncr TYROSINE PHOSPHATASE
(Orf
virus) 		5 / 9 VAL A 127
HIS A 129
GLY A 125
LEU A 148
ARG A 131
 None
 1.46A 6c2mC-5ncrA:
undetectable		 6c2mC-5ncrA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5ncr TYROSINE PHOSPHATASE
(Orf
virus) 		5 / 12 LEU A 162
GLY A 115
GLY A 120
ASP A  81
GLU A 163
 None
PO4  A 200 (-3.4A)
None
PO4  A 200 (-3.8A)
None
 1.06A 6ectA-5ncrA:
undetectable		 6ectA-5ncrA:
19.00