SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ncs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ncs SERPIN
(Tannerella
forsythia) 		3 / 3 MET A 231
ASN A 378
GLN A 247
 None
 0.88A 1xoqB-5ncsA:
undetectable		 1xoqB-5ncsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5ncs SERPIN
(Tannerella
forsythia) 		3 / 3 SER A 212
THR A 207
GLN A 234
 None
 0.81A 2fk8A-5ncsA:
undetectable		 2fk8A-5ncsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5ncs SERPIN
(Tannerella
forsythia) 		5 / 12 SER A  70
SER A  67
ILE A  66
ASN A 197
ILE A 180
 None
 1.06A 2nnhA-5ncsA:
undetectable		 2nnhA-5ncsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5ncs SERPIN
(Tannerella
forsythia) 		5 / 12 PHE A  47
ALA A  93
THR A  54
VAL A  59
LEU A 310
 None
 1.31A 2rctA-5ncsA:
undetectable		 2rctA-5ncsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5ncs SERPIN
(Tannerella
forsythia) 		5 / 11 ALA A  74
HIS A 345
VAL A 343
LEU A 310
LEU A 195
 None
 1.01A 3sm2B-5ncsA:
undetectable		 3sm2B-5ncsA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ncs SERPIN
(Tannerella
forsythia) 		4 / 4 GLU A 405
ASP A 223
ARG A 272
THR A 225
 None
 1.49A 4ej1A-5ncsA:
undetectable		 4ej1A-5ncsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5ncs SERPIN
(Tannerella
forsythia) 		5 / 12 PHE A  47
ALA A  93
THR A  54
VAL A  59
LEU A 310
 None
 1.37A 4qzuA-5ncsA:
undetectable		 4qzuA-5ncsA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 5ncs SERPIN
(Tannerella
forsythia) 		5 / 11 VAL A 396
ILE A 397
ILE A 287
ILE A 286
PHE A  49
 None
 1.26A 5hw8G-5ncsA:
undetectable		 5hw8G-5ncsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5ncs SERPIN
(Tannerella
forsythia) 		3 / 3 ASN A 177
TYR A 200
CYH A 172
 None
 0.90A 5lsuB-5ncsA:
undetectable		 5lsuB-5ncsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ncs SERPIN
(Tannerella
forsythia) 		5 / 12 LEU A 278
PHE A 385
GLY A 401
TYR A 253
ILE A 397
 None
 1.27A 5y2tA-5ncsA:
undetectable		 5y2tA-5ncsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5ncs SERPIN
(Tannerella
forsythia) 		5 / 9 PHE A 387
VAL A 386
GLY A 401
ILE A 287
ASP A 243
 None
 1.44A 6c2mC-5ncsA:
undetectable		 6c2mC-5ncsA:
13.10