SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ncw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		3 / 3 SER A 173
THR A 168
GLN A 195
 None
 0.64A 2fk8A-5ncwA:
undetectable		 2fk8A-5ncwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		5 / 12 PHE A   8
ALA A  54
THR A  15
VAL A  20
LEU A 271
 None
 1.31A 2rctA-5ncwA:
undetectable		 2rctA-5ncwA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		5 / 12 LEU A 271
VAL A  20
ILE A 236
ARG A 233
LEU A  12
 None
 0.96A 3ijdB-5ncwA:
undetectable		 3ijdB-5ncwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		5 / 6 PHE A   8
ASN A  37
ALA A  35
THR A 323
LEU A 271
 None
IOD  A 507 ( 4.8A)
None
None
None
 1.47A 4ejgD-5ncwA:
undetectable		 4ejgD-5ncwA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		4 / 4 ILE A 129
ASN A 130
ILE A 141
VAL A 322
 None
CL  A 513 (-4.5A)
None
None
 1.05A 4uy87-5ncwA:
undetectable		 4uy87-5ncwA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		4 / 4 ILE A 129
ARG A 303
TYR A 155
GLU A 326
 None
CL  A 508 (-3.2A)
None
None
 0.95A 4zzbD-5ncwA:
undetectable		 4zzbD-5ncwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		3 / 3 ARG A 303
TYR A 155
GLU A 326
 CL  A 508 (-3.2A)
None
None
 0.70A 4zzbE-5ncwA:
undetectable		 4zzbE-5ncwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		4 / 5 ILE A 129
ARG A 303
TYR A 155
GLU A 326
 None
CL  A 508 (-3.2A)
None
None
 1.04A 4zzcE-5ncwA:
undetectable		 4zzcE-5ncwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN
(Tannerella
forsythia) 		4 / 5 ILE A 305
ARG A 303
TYR A 155
GLU A 326
 None
CL  A 508 (-3.2A)
None
None
 1.22A 4zzcE-5ncwA:
undetectable		 4zzcE-5ncwA:
21.78