SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 7 PHE A 169
ALA A 270
ILE A 171
ILE A 209
None
None
GTP  A 500 ( 4.7A)
None
0.91A 1oniD-5nd4A:
4.7
1oniF-5nd4A:
4.8
1oniD-5nd4A:
16.21
1oniF-5nd4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 8 PHE A 267
TYR A 432
LEU A 428
ASP A 424
None
1.04A 1rmtD-5nd4A:
undetectable
1rmtD-5nd4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 TYR A 319
ALA A 331
ILE A 335
VAL A 375
ALA A 273
None
1.10A 1udtA-5nd4A:
undetectable
1udtA-5nd4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 TYR A 319
ALA A 331
ILE A 335
VAL A 375
PHE A 296
None
1.11A 1udtA-5nd4A:
undetectable
1udtA-5nd4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
3 / 3 PHE A 395
TYR A 408
TYR A 103
None
0.87A 1x70B-5nd4A:
undetectable
1x70B-5nd4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 10 TYR A 319
ALA A 331
ILE A 335
VAL A 375
ALA A 273
None
1.16A 1xp0A-5nd4A:
undetectable
1xp0A-5nd4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 10 TYR A 319
ALA A 331
ILE A 335
VAL A 375
PHE A 296
None
1.10A 1xp0A-5nd4A:
undetectable
1xp0A-5nd4A:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 5 PRO A 325
VAL A 328
VAL A 353
ILE A 355
None
0.69A 1z2bC-5nd4A:
55.9
1z2bC-5nd4A:
92.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 HIS A 107
HIS A 139
VAL A 137
THR A 194
THR A 193
None
1.04A 1zgfA-5nd4A:
undetectable
1zgfA-5nd4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 LEU A 428
LEU A 195
GLU A 168
SER A 198
ASP A 205
None
1.05A 2bm9A-5nd4A:
3.7
2bm9A-5nd4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 11 PHE A 169
HIS A   8
ASN A 228
ILE A 171
ALA A  19
None
None
GTP  A 500 (-3.0A)
GTP  A 500 ( 4.7A)
None
1.43A 2gl0B-5nd4A:
undetectable
2gl0C-5nd4A:
undetectable
2gl0B-5nd4A:
17.35
2gl0C-5nd4A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
3 / 3 VAL A 437
TRP A 346
VAL A 435
None
0.90A 2izqA-5nd4A:
undetectable
2izqB-5nd4A:
undetectable
2izqA-5nd4A:
3.21
2izqB-5nd4A:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 ILE A 209
SER A 237
ALA A 240
LEU A  23
ILE A 231
None
1.21A 2xkwB-5nd4A:
undetectable
2xkwB-5nd4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 HIS A 107
HIS A 139
VAL A 137
THR A 194
THR A 193
None
0.88A 3bl1A-5nd4A:
undetectable
3bl1A-5nd4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 10 THR A 150
SER A 151
SER A 147
GLY A 146
GLY A 143
None
None
None
GTP  A 500 ( 4.4A)
GTP  A 500 (-3.0A)
1.41A 3ixlA-5nd4A:
2.0
3ixlA-5nd4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 10 THR A 150
SER A 151
SER A 147
GLY A 146
GLY A 144
None
None
None
GTP  A 500 ( 4.4A)
GTP  A 500 (-2.9A)
1.08A 3ixlA-5nd4A:
2.0
3ixlA-5nd4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
6 / 12 ALA A 331
THR A 334
ALA A 333
ALA A 330
VAL A 288
ALA A 294
None
1.46A 3mg0Y-5nd4A:
undetectable
3mg0Z-5nd4A:
undetectable
3mg0Y-5nd4A:
19.09
3mg0Z-5nd4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 5 HIS A 107
SER A 151
THR A 190
GLU A 155
None
1.25A 3tm4A-5nd4A:
3.9
3tm4A-5nd4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 5 HIS A 107
SER A 151
THR A 190
GLU A 155
None
1.21A 3tm4B-5nd4A:
3.8
3tm4B-5nd4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 5 THR A 109
ILE A 110
GLU A  97
PHE A 149
None
1.49A 4acbC-5nd4A:
3.8
4acbC-5nd4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 8 GLU A 433
GLU A 429
TYR A 432
GLY A 310
None
0.91A 4fgzA-5nd4A:
3.0
4fgzB-5nd4A:
2.9
4fgzA-5nd4A:
19.26
4fgzB-5nd4A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 GLY A 106
GLY A 148
ILE A 110
GLU A  97
ASN A 101
None
None
None
None
GTP  A 500 (-3.3A)
1.12A 4fr0A-5nd4A:
3.2
4fr0A-5nd4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
6 / 12 GLY A 146
GLY A 144
GLY A 143
SER A 187
VAL A   9
VAL A 137
GTP  A 500 ( 4.4A)
GTP  A 500 (-2.9A)
GTP  A 500 (-3.0A)
None
None
None
1.25A 4htfA-5nd4A:
3.3
4htfA-5nd4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
6 / 12 GLY A 146
GLY A 144
GLY A 143
SER A 187
VAL A   9
VAL A 137
GTP  A 500 ( 4.4A)
GTP  A 500 (-2.9A)
GTP  A 500 (-3.0A)
None
None
None
1.29A 4htfB-5nd4A:
undetectable
4htfB-5nd4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 HIS A 139
LEU A 119
VAL A 137
THR A 194
THR A 193
None
1.02A 4k0zA-5nd4A:
undetectable
4k0zA-5nd4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 10 LEU A 153
LEU A 152
ARG A 123
LYS A 124
THR A 145
None
None
None
None
GTP  A 500 (-4.0A)
1.24A 4mk4A-5nd4A:
2.7
4mk4A-5nd4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 GLY A 142
TYR A 185
SER A 170
ALA A  12
ASN A 206
None
None
None
GTP  A 500 (-3.3A)
GTP  A 500 (-3.5A)
1.41A 4ymgA-5nd4A:
4.2
4ymgA-5nd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 12 ALA A 126
GLY A 134
GLY A 131
LEU A 167
GLU A 168
None
1.01A 5c0oH-5nd4A:
3.9
5c0oH-5nd4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 5 THR A 382
ALA A 383
TYR A 312
HIS A 309
None
1.05A 5ecmA-5nd4A:
undetectable
5ecmA-5nd4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
3 / 3 MET A 313
HIS A 266
GLY A 436
None
0.84A 5gwzB-5nd4A:
undetectable
5gwzB-5nd4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
4 / 6 TYR A 161
ASP A 120
ILE A 115
ARG A 156
None
1.36A 5igyA-5nd4A:
undetectable
5igyA-5nd4A:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
8 / 12 PRO A 325
VAL A 328
ASN A 329
ILE A 332
ALA A 333
PHE A 351
GLY A 354
ILE A 355
None
1.01A 5j2tC-5nd4A:
54.1
5j2tC-5nd4A:
92.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
8 / 12 PRO A 325
VAL A 328
ILE A 332
ALA A 333
PHE A 351
VAL A 353
GLY A 354
ILE A 355
None
1.01A 5j2tC-5nd4A:
54.1
5j2tC-5nd4A:
92.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 11 GLN A  11
GLU A 183
PRO A 222
TYR A 224
LEU A 227
GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
0.77A 5jh7B-5nd4A:
51.3
5jh7B-5nd4A:
38.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 11 GLN A  11
ASN A 101
PRO A 222
TYR A 224
LEU A 227
GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
0.97A 5jh7D-5nd4A:
51.7
5jh7D-5nd4A:
38.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)
5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus)
5 / 11 GLN A  11
GLU A 183
PRO A 222
TYR A 224
LEU A 227
GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
0.74A 5jh7D-5nd4A:
51.7
5jh7D-5nd4A:
38.90