SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ndf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 8 THR A 459
ASN A 479
ASP A 444
GLY A 477
 None
 1.00A 1bu5B-5ndfA:
undetectable		 1bu5B-5ndfA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 VAL A 468
LEU A 497
SER A 489
LEU A 484
THR A 459
 None
 1.22A 1kw0A-5ndfA:
undetectable		 1kw0A-5ndfA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 11 VAL A 468
LEU A 497
SER A 489
LEU A 484
THR A 459
 None
 1.11A 1mmtA-5ndfA:
undetectable		 1mmtA-5ndfA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 5 ASP A 115
VAL A 157
SER A 158
GLN A  83
 None
 1.37A 1n2xB-5ndfA:
2.0		 1n2xB-5ndfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 LEU A 278
TRP A 276
LEU A 437
PHE A 426
 None
 1.43A 1ru9H-5ndfA:
undetectable
1ru9L-5ndfA:
undetectable		 1ru9H-5ndfA:
16.20
1ru9L-5ndfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 LEU A 278
TRP A 276
LEU A 437
PHE A 426
 None
 1.47A 1rukH-5ndfA:
undetectable
1rukL-5ndfA:
undetectable		 1rukH-5ndfA:
16.20
1rukL-5ndfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 LEU A 349
GLU A 334
GLY A 308
ASN A 335
ALA A 307
 None
EDO  A 604 (-2.8A)
EDO  A 604 (-3.7A)
EDO  A 604 ( 4.3A)
EDO  A 605 ( 3.4A)
 1.15A 2bm9C-5ndfA:
undetectable		 2bm9C-5ndfA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 7 TYR A 396
GLY A 333
THR A 381
ASN A 335
 None
None
None
EDO  A 604 ( 4.3A)
 1.07A 2g70A-5ndfA:
undetectable		 2g70A-5ndfA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 EDO  A 604 (-3.7A)
EDO  A 605 ( 3.4A)
EDO  A 603 ( 4.4A)
None
LU2  A 608 ( 4.0A)
 0.88A 2o4sB-5ndfA:
undetectable		 2o4sB-5ndfA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A 148
GLU A 147
PHE A 361
SER A 225
THR A 155
 None
None
LU2  A 608 ( 3.4A)
UDP  A 602 (-2.9A)
None
 1.28A 2xffA-5ndfA:
undetectable		 2xffA-5ndfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
VAL A 249
VAL A 357
ILE A 253
 EDO  A 604 (-3.7A)
EDO  A 605 ( 3.4A)
None
None
LU2  A 608 ( 4.0A)
 0.96A 3cyxA-5ndfA:
undetectable		 3cyxA-5ndfA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 EDO  A 604 (-3.7A)
EDO  A 605 ( 3.4A)
EDO  A 603 ( 4.4A)
None
LU2  A 608 ( 4.0A)
 0.96A 3nu3A-5ndfA:
undetectable		 3nu3A-5ndfA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 9 GLY A 308
ALA A 307
VAL A 249
VAL A 357
ILE A 253
 EDO  A 604 (-3.7A)
EDO  A 605 ( 3.4A)
None
None
LU2  A 608 ( 4.0A)
 0.89A 3oxvA-5ndfA:
undetectable		 3oxvA-5ndfA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 EDO  A 604 (-3.7A)
EDO  A 605 ( 3.4A)
EDO  A 603 ( 4.4A)
None
LU2  A 608 ( 4.0A)
 1.00A 3oxxC-5ndfA:
undetectable		 3oxxC-5ndfA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
VAL A 249
VAL A 357
ILE A 253
 EDO  A 604 (-3.7A)
EDO  A 605 ( 3.4A)
None
None
LU2  A 608 ( 4.0A)
 1.00A 3oxxC-5ndfA:
undetectable		 3oxxC-5ndfA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 5 LEU A 278
ALA A 384
MET A 305
ASN A 335
 None
None
None
EDO  A 604 ( 4.3A)
 1.39A 3uq6A-5ndfA:
undetectable		 3uq6A-5ndfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 5 TYR A 367
HIS A 365
ASP A 224
TYR A 324
 UDP  A 602 (-3.7A)
None
UDP  A 602 ( 3.2A)
None
 1.49A 4qdjA-5ndfA:
undetectable		 4qdjA-5ndfA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A 151
GLY A 358
ALA A 148
ARG A 149
TYR A  86
 None
 1.13A 5zvgB-5ndfA:
undetectable		 5zvgB-5ndfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 GLY A  88
ASP A 110
SER A 150
ARG A 149
 None
 1.18A 6dwdA-5ndfA:
undetectable
6dwdC-5ndfA:
undetectable		 6dwdA-5ndfA:
22.40
6dwdC-5ndfA:
22.40