SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ndx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 7 LEU A 249
TYR A 248
HIS A 253
THR A 184
 None
 1.14A 1afsA-5ndxA:
7.6		 1afsA-5ndxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 7 LEU A 249
TYR A 248
HIS A 253
THR A 184
 None
 1.14A 1afsB-5ndxA:
undetectable		 1afsB-5ndxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 TRP A 116
ALA A 168
VAL A 120
 None
 0.90A 1av2C-5ndxA:
undetectable
1av2D-5ndxA:
undetectable		 1av2C-5ndxA:
undetectable
1av2D-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 11 SER A 218
GLY A 181
GLY A 183
PHE A  93
ASP A 264
 None
None
None
8U8  A 713 (-4.1A)
None
 1.47A 1ho5A-5ndxA:
2.7		 1ho5A-5ndxA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 ARG A 542
THR A 355
VAL A 352
 None
 0.75A 1hxbA-5ndxA:
undetectable		 1hxbA-5ndxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 TRP A 116
ALA A 168
VAL A 120
 None
 0.97A 1w5uA-5ndxA:
undetectable
1w5uB-5ndxA:
undetectable		 1w5uA-5ndxA:
undetectable
1w5uB-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 ALA A 168
VAL A 120
TRP A 116
 None
 0.96A 2izqA-5ndxA:
undetectable
2izqB-5ndxA:
undetectable		 2izqA-5ndxA:
undetectable
2izqB-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 12 LEU A 375
PHE A  18
ILE A 292
LEU A 428
VAL A 430
 None
 1.21A 2po5A-5ndxA:
undetectable		 2po5A-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 ARG A 542
THR A 355
VAL A 352
 None
 0.92A 2q64A-5ndxA:
undetectable		 2q64A-5ndxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 ARG A 542
THR A 355
VAL A 352
 None
 0.81A 2qakA-5ndxA:
undetectable		 2qakA-5ndxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 SER A 368
HIS A 413
ASP A 513
 None
 0.80A 2wa2B-5ndxA:
undetectable		 2wa2B-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 5 SER A 595
LEU A 546
GLY A 548
GLU A 480
 None
 0.97A 3aiaA-5ndxA:
undetectable
3aiaB-5ndxA:
undetectable		 3aiaA-5ndxA:
undetectable
3aiaB-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 8 PRO A 190
ALA A 194
ALA A 197
ILE A 156
 None
 0.77A 3dtuC-5ndxA:
undetectable
3dtuD-5ndxA:
undetectable		 3dtuC-5ndxA:
undetectable
3dtuD-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 6 LEU A 366
SER A 368
ILE A  53
PHE A  21
 None
 0.98A 3ko0S-5ndxA:
undetectable		 3ko0S-5ndxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 8 HIS A 279
LEU A 310
ASP A 267
ASP A 313
 None
None
8U8  A 712 ( 4.8A)
8U8  A 712 (-3.6A)
 1.25A 3n2oC-5ndxA:
8.3
3n2oD-5ndxA:
2.3		 3n2oC-5ndxA:
8.25
3n2oD-5ndxA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 12 HIS A 314
LEU A 372
ILE A 288
GLY A 286
ALA A 285
 None
 1.09A 3n8xB-5ndxA:
undetectable		 3n8xB-5ndxA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 10 LEU A 371
ALA A 289
ILE A 287
ILE A 397
LEU A 519
 None
 1.26A 3ogpB-5ndxA:
undetectable		 3ogpB-5ndxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 ASP A 313
GLU A 142
SER A 273
 8U8  A 712 (-3.6A)
None
None
 0.85A 3p2kA-5ndxA:
undetectable		 3p2kA-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 12 LEU A  61
TYR A  62
TRP A 139
PHE A 141
TYR A 216
 None
None
None
None
8U8  A 713 (-3.8A)
 1.45A 3r94A-5ndxA:
7.7		 3r94A-5ndxA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 ASN A   8
GLU A 429
ARG A 507
 None
 1.04A 3wxoA-5ndxA:
0.0		 3wxoA-5ndxA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 7 PHE A 316
ALA A 315
THR A  25
LEU A  33
 None
 1.10A 4ejgA-5ndxA:
undetectable		 4ejgA-5ndxA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 8 LEU A 395
SER A 518
THR A 520
VAL A 522
 None
 0.59A 4ik7B-5ndxA:
undetectable		 4ik7B-5ndxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 12 HIS A 220
GLU A  95
GLU A 142
ASP A 264
SER A 218
 8U8  A 712 ( 4.7A)
None
None
None
None
 1.41A 4r88B-5ndxA:
6.1		 4r88B-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 12 HIS A 220
GLU A  95
GLU A 142
ASP A 264
SER A 218
 8U8  A 712 ( 4.7A)
None
None
None
None
 1.41A 4r88F-5ndxA:
4.1		 4r88F-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 11 GLY A  26
SER A 312
ILE A 288
ILE A  45
MET A  41
 None
 1.15A 4xumB-5ndxA:
undetectable		 4xumB-5ndxA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 5 TYR A 107
GLY A  98
TYR A 154
GLY A 150
 None
 0.86A 5ayfA-5ndxA:
undetectable		 5ayfA-5ndxA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		5 / 12 LEU A  48
GLY A  52
ARG A  23
SER A 410
LEU A 366
 None
None
8U8  A 713 ( 3.7A)
None
None
 1.19A 5czyA-5ndxA:
1.5		 5czyA-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 GLU A 485
TRP A 456
ASN A 451
 None
 1.08A 5dv4A-5ndxA:
undetectable		 5dv4A-5ndxA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 7 ILE A 217
LEU A 195
PHE A 192
TYR A 162
 None
 0.82A 5h3aB-5ndxA:
undetectable		 5h3aB-5ndxA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 4 LEU A 310
ARG A  23
ILE A 292
PHE A  21
 None
8U8  A 713 ( 3.7A)
None
None
 1.35A 5kirB-5ndxA:
undetectable		 5kirB-5ndxA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 6 PHE A  55
SER A 311
ARG A  57
GLY A  26
 8U8  A 713 (-3.9A)
None
None
None
 1.14A 5o4yF-5ndxA:
undetectable		 5o4yF-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		3 / 3 ASN A 306
VAL A 239
HIS A 295
 None
 0.81A 6a5yD-5ndxA:
undetectable		 6a5yD-5ndxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 5 VAL A 426
LEU A 512
HIS A 496
THR A 520
 None
 1.48A 6dyoA-5ndxA:
undetectable		 6dyoA-5ndxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5ndx GLYCOSYL HYDROLASE
(Rhizobium
leguminosarum) 		4 / 6 ARG A 193
SER A 189
THR A 160
ALA A 197
 None
 1.11A 6ma6A-5ndxA:
undetectable		 6ma6A-5ndxA:
17.24