SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 SER A 144
ASP A 103
GLU A 583
GLU A 536
 None
 1.15A 1knyA-5necA:
undetectable
1knyB-5necA:
undetectable		 1knyA-5necA:
17.09
1knyB-5necA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 536
SER A 144
ASP A 103
GLU A 583
 None
 1.14A 1knyA-5necA:
undetectable
1knyB-5necA:
undetectable		 1knyA-5necA:
17.09
1knyB-5necA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 142
SER A 144
ASN A 479
GLY A 130
GLN A 481
 None
 1.30A 2hmaA-5necA:
undetectable		 2hmaA-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 THR A 237
TYR A 375
TRP A 311
THR A 270
 None
 1.42A 2qmjA-5necA:
0.3		 2qmjA-5necA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 451
ALA A 435
SER A 360
SER A 133
ALA A 134
 None
 1.36A 2vh3A-5necA:
undetectable		 2vh3A-5necA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 531
ASP A 558
TYR A 535
 None
None
C8E  A 802 ( 3.9A)
 0.87A 2yvlB-5necA:
undetectable		 2yvlB-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 258
ILE A 242
PRO A 243
TYR A 714
 None
 1.37A 3d9lA-5necA:
undetectable
3d9lY-5necA:
undetectable		 3d9lA-5necA:
undetectable
3d9lY-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 368
GLY A 428
THR A 458
GLU A 457
 None
 1.04A 3e9xA-5necA:
undetectable		 3e9xA-5necA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 ILE A  78
ARG A  50
ILE A  95
THR A  74
 None
 1.19A 3ia4C-5necA:
undetectable		 3ia4C-5necA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 THR A 426
LYS A  87
GLU A 368
 None
 0.81A 3ijdB-5necA:
undetectable		 3ijdB-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 708
ILE A 119
PHE A 120
 None
 1.00A 3j7zS-5necA:
undetectable
3j7za-5necA:
undetectable		 3j7zS-5necA:
undetectable
3j7za-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 SER A 228
PHE A 187
LEU A 174
ASP A 175
 None
 1.03A 3m0wE-5necA:
undetectable
3m0wF-5necA:
undetectable
3m0wG-5necA:
undetectable
3m0wH-5necA:
undetectable		 3m0wE-5necA:
18.00
3m0wF-5necA:
18.00
3m0wG-5necA:
18.00
3m0wH-5necA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 125
SER A 149
ASN A 121
ILE A  60
ALA A  71
 None
 1.39A 3u6tA-5necA:
undetectable		 3u6tA-5necA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 603
MET A 631
ASP A  99
 None
 0.63A 3v5wA-5necA:
undetectable		 3v5wA-5necA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 320
LEU A 269
ASP A 411
GLY A 394
ILE A 393
 None
 1.32A 4djeA-5necA:
undetectable		 4djeA-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 SER A 234
ASP A 235
SER A 207
ASP A 205
 None
 1.20A 4eysA-5necA:
undetectable		 4eysA-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 185
ASN A 184
LEU A 219
ASP A 182
 None
 1.01A 4g24A-5necA:
undetectable		 4g24A-5necA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 SER A 128
TYR A  41
PRO A 131
GLN A 481
 None
 1.14A 4j7uD-5necA:
undetectable		 4j7uD-5necA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 547
ASP A  34
ASP A  47
 None
 0.78A 4kicB-5necA:
undetectable		 4kicB-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  72
ARG A  73
MET A 682
 None
 0.97A 4m11C-5necA:
undetectable		 4m11C-5necA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  97
ASP A  99
GLY A 581
ASN A 534
PHE A 555
 None
 1.07A 4obwB-5necA:
undetectable		 4obwB-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 121
SER A 214
ALA A 212
VAL A 211
 None
 1.06A 4x1kC-5necA:
undetectable		 4x1kC-5necA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 121
SER A 228
ALA A 212
VAL A 211
 None
 1.03A 4x1kC-5necA:
undetectable		 4x1kC-5necA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 159
GLU A 123
SER A 688
 None
 0.82A 5bw4B-5necA:
undetectable		 5bw4B-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 190
SER A 228
ALA A 212
VAL A 211
 None
 0.93A 5nm5A-5necA:
undetectable		 5nm5A-5necA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 487
TRP A 486
SER A 493
 None
 1.23A 5nwwA-5necA:
undetectable		 5nwwA-5necA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 SER A 625
GLU A 606
ARG A 578
ASP A 558
 None
 1.30A 5zw4A-5necA:
undetectable		 5zw4A-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 437
ILE A 449
PRO A  49
SER A 133
PHE A 436
 None
 1.23A 6fbpA-5necA:
undetectable
6fbpB-5necA:
undetectable		 6fbpA-5necA:
23.08
6fbpB-5necA:
23.08