SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		3 / 3 PHE B 308
LEU B 317
SER B 254
 None
 0.88A 1e7aA-5nemB:
undetectable		 1e7aA-5nemB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 VAL B 247
ILE B 340
ASN B 204
SER B 140
LEU B 115
 None
 1.18A 1fm4A-5nemB:
undetectable		 1fm4A-5nemB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 8 LEU B 306
TYR B 318
TYR B 321
LEU B 295
 None
 0.92A 1s1xA-5nemB:
undetectable		 1s1xA-5nemB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 GLY B 222
ASN B 215
ASP B 224
ALA B 225
ALA B 229
 None
 1.17A 2br4B-5nemB:
undetectable		 2br4B-5nemB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 10 SER B 213
ILE B 212
PHE B 154
LEU B 139
GLY B 155
 None
 1.33A 2v0mA-5nemB:
undetectable		 2v0mA-5nemB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 PHE B 154
TYR B 117
LEU B 246
SER B 124
SER B 122
 None
 1.24A 2vdmA-5nemB:
undetectable
2vdmB-5nemB:
38.9		 2vdmA-5nemB:
22.35
2vdmB-5nemB:
50.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 4 TYR B 116
LEU B 115
LEU B 196
HIS B 192
 None
 1.42A 2x7hB-5nemB:
undetectable		 2x7hB-5nemB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 4 TYR B 116
LEU B 152
LEU B 196
HIS B 192
 None
 1.22A 2x7hB-5nemB:
undetectable		 2x7hB-5nemB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 LEU B 424
ILE B 413
LEU B 366
ILE B 415
PRO B 404
 None
 0.95A 2ygqA-5nemB:
undetectable		 2ygqA-5nemB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 7 SER B 337
TYR B 117
ILE B 132
ASP B 128
 None
 0.83A 3bu1A-5nemB:
undetectable		 3bu1A-5nemB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		3 / 3 ASP B 127
ASN B 130
SER B 124
 None
 0.95A 3lslA-5nemB:
undetectable
3lslD-5nemB:
undetectable		 3lslA-5nemB:
18.88
3lslD-5nemB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		3 / 3 SER B 124
ASP B 127
ASN B 130
 None
 0.91A 3lslA-5nemB:
undetectable
3lslD-5nemB:
undetectable		 3lslA-5nemB:
18.88
3lslD-5nemB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 8 LEU B 306
TYR B 318
TYR B 321
LEU B 295
 None
 0.84A 3v81C-5nemB:
1.9		 3v81C-5nemB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 ALA B 263
TYR B 281
ASP B 224
GLY B 264
ILE B 265
 None
 1.30A 3vwqA-5nemB:
undetectable		 3vwqA-5nemB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 ASN B 269
ALA B 225
GLY B 222
GLY B 221
GLY B 155
 None
 1.02A 4obwB-5nemB:
undetectable		 4obwB-5nemB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		5 / 12 ILE B 292
ALA B 328
LEU B 295
LEU B 299
PHE B 308
 None
 1.26A 4pbhA-5nemB:
undetectable		 4pbhA-5nemB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 6 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.78A 4qogA-5nemB:
3.8
4qogB-5nemB:
undetectable		 4qogA-5nemB:
18.30
4qogB-5nemB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 4 VAL B 103
ALA B  85
ASN B  67
GLN B  87
 None
 1.39A 4zgfA-5nemB:
undetectable		 4zgfA-5nemB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5nem INTEGRIN BETA-6
(Homo
sapiens) 		4 / 4 VAL B 315
GLU B 319
GLY B 331
LEU B 332
 None
 0.83A 5g5gC-5nemB:
undetectable		 5g5gC-5nemB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5nem O PANASIA VP4
(Foot-and-mouth
disease
virus) 		3 / 3 SER 4  69
LYS 4  70
SER 4  73
 None
 0.71A 6az3P-5nem4:
undetectable		 6az3P-5nem4:
18.99