SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		3 / 3 VAL A 155
ALA A 156
HIS A 223
 None
 0.76A 1q23G-5nfbA:
undetectable		 1q23G-5nfbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		3 / 3 VAL A 155
ALA A 156
HIS A 223
 None
 0.64A 1q23J-5nfbA:
undetectable		 1q23J-5nfbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 12 ILE A 171
PHE A 192
ASP A 239
GLY A 238
PHE A 190
 None
 1.23A 1zz1B-5nfbA:
undetectable
1zz1C-5nfbA:
undetectable		 1zz1B-5nfbA:
18.78
1zz1C-5nfbA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5nfb GALECTIN-3
(Homo
sapiens) 		4 / 7 ASN A 214
ASP A 215
THR A 243
GLY A 136
 None
 1.01A 2f6dA-5nfbA:
undetectable		 2f6dA-5nfbA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 12 PHE A 157
VAL A 211
PHE A 190
PHE A 163
ALA A 146
 None
 1.50A 3apwA-5nfbA:
undetectable		 3apwA-5nfbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 5nfb GALECTIN-3
(Homo
sapiens) 		4 / 5 VAL A 172
PHE A 149
ARG A 186
ARG A 169
 None
None
8VT  A 301 (-3.4A)
None
 1.43A 3bjwE-5nfbA:
undetectable		 3bjwE-5nfbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5nfb GALECTIN-3
(Homo
sapiens) 		6 / 6 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
 8VT  A 301 (-3.9A)
8VT  A 301 (-4.0A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.8A)
8VT  A 301 ( 3.7A)
8VT  A 301 (-2.7A)
 0.21A 3galA-5nfbA:
22.9		 3galA-5nfbA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5nfb GALECTIN-3
(Homo
sapiens) 		6 / 6 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
 8VT  A 301 (-3.9A)
8VT  A 301 (-4.0A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.8A)
8VT  A 301 ( 3.7A)
8VT  A 301 (-2.7A)
 0.29A 3galB-5nfbA:
23.1		 3galB-5nfbA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 9 ALA A 156
ASP A 154
GLY A 235
VAL A 126
ILE A 231
 None
 1.06A 3nu4A-5nfbA:
undetectable		 3nu4A-5nfbA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 9 ALA A 156
ASP A 154
GLY A 235
VAL A 126
ILE A 231
 None
 1.10A 3nuoA-5nfbA:
undetectable		 3nuoA-5nfbA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		4 / 6 LEU A 218
LEU A 219
LEU A 147
PRO A 161
 None
 1.04A 3q1eA-5nfbA:
undetectable
3q1eC-5nfbA:
undetectable		 3q1eA-5nfbA:
23.30
3q1eC-5nfbA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 12 PHE A 198
ILE A 200
GLY A 235
PHE A 159
LEU A 242
 None
 0.96A 5byjA-5nfbA:
undetectable		 5byjA-5nfbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 12 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
 None
 1.04A 5i71A-5nfbA:
undetectable		 5i71A-5nfbA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 12 ASP A 215
ILE A 200
PHE A 192
LEU A 219
GLY A 136
 None
 1.05A 5i75A-5nfbA:
undetectable		 5i75A-5nfbA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 10 LEU A 122
ILE A 231
ALA A 156
PHE A 209
VAL A 202
 None
 0.95A 5m0oA-5nfbA:
undetectable		 5m0oA-5nfbA:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5nfb GALECTIN-3
(Homo
sapiens) 		4 / 7 ARG A 186
ASN A 166
GLU A 165
ARG A 162
 8VT  A 301 (-3.4A)
None
8VT  A 301 (-3.5A)
8VT  A 301 (-2.7A)
 1.28A 6b8kA-5nfbA:
29.9		 6b8kA-5nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5nfb GALECTIN-3
(Homo
sapiens) 		7 / 7 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
ARG A 186
 8VT  A 301 (-3.9A)
8VT  A 301 (-4.0A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.8A)
8VT  A 301 ( 3.7A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.4A)
 0.09A 6b8kA-5nfbA:
29.9		 6b8kA-5nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 5nfb GALECTIN-3
(Homo
sapiens) 		7 / 8 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
ARG A 186
 8VT  A 301 (-3.9A)
8VT  A 301 (-4.0A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.8A)
8VT  A 301 ( 3.7A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.4A)
 0.48A 6b94A-5nfbA:
19.8		 6b94A-5nfbA:
37.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 5nfb GALECTIN-3
(Homo
sapiens) 		7 / 10 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
ARG A 186
 8VT  A 301 (-3.9A)
8VT  A 301 (-4.0A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.8A)
8VT  A 301 ( 3.7A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.4A)
 0.34A 6b94A-5nfbA:
19.8
6b94B-5nfbA:
19.4		 6b94A-5nfbA:
37.63
6b94B-5nfbA:
37.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5nfb GALECTIN-3
(Homo
sapiens) 		5 / 12 LEU A 242
LEU A 120
PRO A 121
ILE A 132
VAL A 202
 None
 1.21A 6debB-5nfbA:
undetectable		 6debB-5nfbA:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 5nfb GALECTIN-3
(Homo
sapiens) 		4 / 4 ARG A 162
GLU A 165
GLU A 184
ARG A 186
 8VT  A 301 (-2.7A)
8VT  A 301 (-3.5A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.4A)
 0.07A 6fk2A-5nfbA:
29.8		 6fk2A-5nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 5nfb GALECTIN-3
(Homo
sapiens) 		4 / 4 ARG A 186
GLU A 184
GLU A 165
ARG A 162
 8VT  A 301 (-3.4A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.5A)
8VT  A 301 (-2.7A)
 1.06A 6fk2A-5nfbA:
29.8		 6fk2A-5nfbA:
100.00