SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.74A 1c6yB-5nfgA:
6.7		 1c6yB-5nfgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 8 SER A  90
THR A 153
LEU A  86
TRP A  87
 None
 1.13A 1mxgA-5nfgA:
undetectable		 1mxgA-5nfgA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 11 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.74A 1sdvB-5nfgA:
7.1		 1sdvB-5nfgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 5 PHE A  79
LEU A  86
PHE A 218
MET A 189
 None
 1.34A 1wrkB-5nfgA:
undetectable		 1wrkB-5nfgA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.82A 2avoB-5nfgA:
7.2		 2avoB-5nfgA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.80A 2avsB-5nfgA:
7.1		 2avsB-5nfgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.74A 2bpxB-5nfgA:
5.7		 2bpxB-5nfgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 11 PRO A  89
ARG A 104
VAL A  77
GLY A 214
GLU A 215
 None
 1.40A 2h9tH-5nfgA:
undetectable		 2h9tH-5nfgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.63A 2o4sB-5nfgA:
7.1		 2o4sB-5nfgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.34A 2oaxB-5nfgA:
undetectable		 2oaxB-5nfgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.35A 2oaxC-5nfgA:
undetectable		 2oaxC-5nfgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.30A 2oaxD-5nfgA:
undetectable		 2oaxD-5nfgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.31A 2oaxE-5nfgA:
undetectable		 2oaxE-5nfgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.26A 2oaxF-5nfgA:
undetectable		 2oaxF-5nfgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.75A 2r5pB-5nfgA:
7.2		 2r5pB-5nfgA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.75A 2r5pD-5nfgA:
7.2		 2r5pD-5nfgA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 11 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.82A 2r5qB-5nfgA:
7.1		 2r5qB-5nfgA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.82A 2r5qD-5nfgA:
7.1		 2r5qD-5nfgA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		7 / 12 ASP A  80
GLY A  82
SER A  83
PHE A 166
ASP A 267
GLY A 269
SER A 271
 None
 0.52A 2v0zC-5nfgA:
44.7		 2v0zC-5nfgA:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		6 / 12 ASP A  80
GLY A  82
PHE A 166
ASP A 267
GLY A 269
SER A 271
 None
 0.53A 2v0zO-5nfgA:
44.2		 2v0zO-5nfgA:
39.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 8 GLY A 316
LEU A 319
PHE A 320
PHE A 362
 None
 0.88A 2vctA-5nfgA:
undetectable		 2vctA-5nfgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 8 GLY A 316
LEU A 319
PHE A 320
PHE A 362
 None
 0.89A 2vctB-5nfgA:
undetectable		 2vctB-5nfgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 7 GLY A 316
LEU A 319
PHE A 320
PHE A 362
 None
 0.92A 2vctD-5nfgA:
undetectable		 2vctD-5nfgA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
PHE A 166
ASP A 267
SER A 271
 None
 0.62A 3d91A-5nfgA:
44.4		 3d91A-5nfgA:
39.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.81A 3ekpD-5nfgA:
6.9		 3ekpD-5nfgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 8 ASP A  80
GLY A  82
ASP A  85
ILE A 169
 None
 0.61A 3el0A-5nfgA:
7.0		 3el0A-5nfgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 9 ARG A 104
ASP A 167
ALA A  76
GLY A  67
ILE A  68
 None
 1.23A 3el4B-5nfgA:
7.0		 3el4B-5nfgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 4 PRO A  89
THR A 153
GLY A 127
THR A 126
 None
 1.05A 3ib1A-5nfgA:
undetectable		 3ib1A-5nfgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 SER A 110
LEU A  86
ILE A  66
SER A 137
GLY A  67
 None
 1.39A 3ijxB-5nfgA:
undetectable
3ijxD-5nfgA:
undetectable		 3ijxB-5nfgA:
20.41
3ijxD-5nfgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 ILE A  66
SER A 137
GLY A  67
SER A 110
LEU A  86
 None
 1.41A 3ik6B-5nfgA:
undetectable
3ik6E-5nfgA:
undetectable		 3ik6B-5nfgA:
20.41
3ik6E-5nfgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A  85
ILE A 122
ILE A 169
 None
 0.80A 3nu5B-5nfgA:
6.9		 3nu5B-5nfgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
GLY A  82
ASP A 267
THR A 270
ILE A 357
 None
 0.57A 3prsA-5nfgA:
38.3		 3prsA-5nfgA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ASP A  80
PHE A 161
ILE A 265
THR A 270
ILE A 357
 None
 0.69A 3pwwA-5nfgA:
38.1		 3pwwA-5nfgA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 8 GLY A  82
SER A  83
ILE A 122
ASP A 267
 None
 0.35A 3pwwA-5nfgA:
38.2		 3pwwA-5nfgA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		6 / 12 ILE A  78
ASP A  80
GLY A  82
ASP A 267
THR A 270
ILE A 357
 None
 0.59A 3q70A-5nfgA:
35.0		 3q70A-5nfgA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		6 / 12 ILE A 169
ASP A  80
GLY A  82
ASP A 267
THR A 270
ILE A 357
 None
 1.26A 3q70A-5nfgA:
35.0		 3q70A-5nfgA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ILE A 265
ASP A 267
GLY A 269
ILE A 348
ASP A  80
 None
 0.71A 3q70A-5nfgA:
35.0		 3q70A-5nfgA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		6 / 12 ILE A  78
ASP A  80
GLY A  82
ILE A 122
ASP A 267
ILE A 357
 None
 0.55A 3tneA-5nfgA:
35.2		 3tneA-5nfgA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ILE A 265
ASP A 267
GLY A 269
ASP A  80
ILE A 169
 None
 0.75A 3tneA-5nfgA:
35.2		 3tneA-5nfgA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		6 / 12 ILE A  78
ASP A  80
GLY A  82
ILE A 122
ASP A 267
ILE A 357
 None
 0.61A 3tneB-5nfgA:
35.1		 3tneB-5nfgA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ILE A 265
ASP A 267
GLY A 269
ASP A  80
ILE A 169
 None
 0.76A 3tneB-5nfgA:
35.1		 3tneB-5nfgA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 7 GLY A 168
ILE A 169
VAL A 140
VAL A 138
 None
 0.82A 3ufnB-5nfgA:
7.4		 3ufnB-5nfgA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.25A 3vhuA-5nfgA:
undetectable		 3vhuA-5nfgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 LEU A 249
GLY A 256
ASN A 284
PHE A 343
THR A 344
 None
 1.36A 5d0yA-5nfgA:
undetectable		 5d0yA-5nfgA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 4 LEU A  86
ILE A 151
GLY A 171
ILE A 122
 None
 0.89A 5dzk3-5nfgA:
undetectable
5dzkm-5nfgA:
undetectable		 5dzk3-5nfgA:
25.00
5dzkm-5nfgA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 PHE A 202
ASP A 267
PHE A 370
ASP A  80
LEU A 172
 None
 1.50A 5eenB-5nfgA:
undetectable		 5eenB-5nfgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 6 PHE A 174
LEU A 172
TRP A 241
GLY A  82
 None
 0.91A 5o4yA-5nfgA:
undetectable		 5o4yA-5nfgA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		4 / 6 PHE A 174
LEU A 172
TRP A 241
GLY A  82
 None
 1.12A 5o4yF-5nfgA:
undetectable		 5o4yF-5nfgA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		6 / 12 PHE A  79
PHE A 174
PHE A 218
ALA A 266
ILE A 265
GLY A  82
 None
 1.50A 5veuB-5nfgA:
undetectable		 5veuB-5nfgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 SER A 110
LEU A  86
ILE A  66
SER A 137
GLY A  67
 None
 1.29A 6dlzA-5nfgA:
undetectable
6dlzD-5nfgA:
undetectable		 6dlzA-5nfgA:
11.50
6dlzD-5nfgA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 ILE A  66
SER A 137
GLY A  67
SER A 110
LEU A  86
 None
 1.29A 6dlzB-5nfgA:
undetectable
6dlzC-5nfgA:
undetectable		 6dlzB-5nfgA:
11.50
6dlzC-5nfgA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 SER A 110
LEU A  86
ILE A  66
SER A 137
GLY A  67
 None
 1.25A 6dm0B-5nfgA:
undetectable
6dm0C-5nfgA:
undetectable		 6dm0B-5nfgA:
11.50
6dm0C-5nfgA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 SER A 110
LEU A  86
ILE A  66
SER A 137
GLY A  67
 None
 1.30A 6dm1A-5nfgA:
undetectable
6dm1D-5nfgA:
undetectable		 6dm1A-5nfgA:
11.50
6dm1D-5nfgA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 10 ILE A  66
SER A 137
GLY A  67
SER A 110
LEU A  86
 None
 1.30A 6dm1B-5nfgA:
undetectable
6dm1C-5nfgA:
undetectable		 6dm1B-5nfgA:
11.50
6dm1C-5nfgA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5nfg PROCARDOSIN-B,PROCAR
DOSIN-B
(Cynara
cardunculus) 		5 / 12 PHE A 313
GLY A 246
GLY A 316
ILE A 311
VAL A 233
 None
 1.05A 6mhtA-5nfgA:
undetectable		 6mhtA-5nfgA:
22.74