SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 GLY A 258
SER A 262
PHE A 315
PHE A 319
 None
 1.00A 1ax9A-5nfhA:
undetectable		 1ax9A-5nfhA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		7 / 11 HIS A 256
GLY A 258
HIS A 259
GLY A 516
ASP A 518
ILE A 519
HIS A 545
 None
None
None
None
None
MET  A 807 ( 4.4A)
None
 0.60A 1pg2A-5nfhA:
34.3		 1pg2A-5nfhA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		6 / 12 THR A 651
ALA A 652
LEU A 712
LEU A 713
ILE A 675
GLY A 705
 None
 1.48A 1qknA-5nfhA:
undetectable		 1qknA-5nfhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 258
HIS A 259
GLY A 516
ASP A 518
HIS A 545
 None
 0.49A 1qu2A-5nfhA:
21.1		 1qu2A-5nfhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 HIS A 256
GLY A 258
HIS A 259
ASP A 518
HIS A 545
 None
 0.84A 1qu2A-5nfhA:
21.1		 1qu2A-5nfhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ARG A 434
ALA A 524
ILE A 515
PRO A 429
ILE A 427
 None
 1.04A 2o4lA-5nfhA:
undetectable		 2o4lA-5nfhA:
11.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		7 / 11 HIS A 256
GLY A 258
HIS A 259
GLY A 516
ASP A 518
ILE A 519
HIS A 545
 None
None
None
None
None
MET  A 807 ( 4.4A)
None
 0.40A 2x1lA-5nfhA:
45.1		 2x1lA-5nfhA:
42.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 HIS A 259
GLY A 258
GLY A 516
ASP A 518
HIS A 545
 None
 1.00A 2x1lA-5nfhA:
45.1		 2x1lA-5nfhA:
42.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		7 / 12 HIS A 256
GLY A 258
HIS A 259
GLY A 516
ASP A 518
ILE A 519
HIS A 545
 None
None
None
None
None
MET  A 807 ( 4.4A)
None
 0.44A 2x1lB-5nfhA:
43.0		 2x1lB-5nfhA:
42.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 HIS A 259
GLY A 258
GLY A 516
ASP A 518
HIS A 545
 None
 1.04A 2x1lB-5nfhA:
43.0		 2x1lB-5nfhA:
42.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		7 / 11 HIS A 256
GLY A 258
HIS A 259
GLY A 516
ASP A 518
ILE A 519
HIS A 545
 None
None
None
None
None
MET  A 807 ( 4.4A)
None
 0.44A 2x1lC-5nfhA:
43.0		 2x1lC-5nfhA:
42.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 HIS A 259
GLY A 258
GLY A 516
ASP A 518
HIS A 545
 None
 1.03A 2x1lC-5nfhA:
43.0		 2x1lC-5nfhA:
42.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 TYR A 700
GLU A 704
ASN A 740
 None
 1.00A 2y7hC-5nfhA:
1.9		 2y7hC-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.10A 3lxiA-5nfhA:
undetectable		 3lxiA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 THR A 710
THR A 702
LEU A 610
LEU A 613
THR A 618
 None
 1.17A 3lxiA-5nfhA:
undetectable		 3lxiA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 4 TYR A 634
TYR A 700
GLU A 704
GLY A 744
 None
 1.33A 3reqA-5nfhA:
3.1		 3reqA-5nfhA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 4 LYS A 540
PRO A 539
LEU A 538
ASN A 423
 None
 1.45A 3tpxC-5nfhA:
0.4		 3tpxC-5nfhA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A 481
HIS A 337
TRP A 527
LEU A 475
 MET  A 807 ( 4.9A)
None
None
None
 1.39A 3uzzB-5nfhA:
undetectable		 3uzzB-5nfhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 519
ILE A 542
ALA A 544
PRO A 247
ILE A 248
 MET  A 807 ( 4.4A)
None
None
MET  A 807 ( 4.7A)
MET  A 807 (-4.8A)
 0.97A 3vrmA-5nfhA:
undetectable		 3vrmA-5nfhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 9 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.06A 4c9kA-5nfhA:
undetectable		 4c9kA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 9 THR A 710
THR A 702
LEU A 610
LEU A 613
THR A 618
 None
 1.22A 4c9kA-5nfhA:
undetectable		 4c9kA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 9 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.04A 4c9kB-5nfhA:
undetectable		 4c9kB-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.06A 4c9lA-5nfhA:
undetectable		 4c9lA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.05A 4c9lB-5nfhA:
undetectable		 4c9lB-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.06A 4c9nB-5nfhA:
undetectable		 4c9nB-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.05A 4c9oA-5nfhA:
2.6		 4c9oA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
 None
 1.04A 4c9oB-5nfhA:
undetectable		 4c9oB-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ARG A 451
THR A 398
ILE A 365
THR A 455
 None
 0.87A 4eq4A-5nfhA:
undetectable		 4eq4A-5nfhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ARG A 451
THR A 398
ILE A 365
THR A 455
 None
 0.86A 4eqlA-5nfhA:
undetectable		 4eqlA-5nfhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ARG A 451
THR A 398
ILE A 365
THR A 455
 None
 0.85A 4eqlB-5nfhA:
undetectable		 4eqlB-5nfhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 HIS A 395
SER A 366
GLU A 368
LEU A 447
LEU A 371
 GOL  A 804 (-3.7A)
None
None
DMS  A 806 ( 4.6A)
None
 1.40A 4foxC-5nfhA:
undetectable		 4foxC-5nfhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 610
LEU A 711
PHE A 725
PRO A 715
ASP A 726
 None
 1.33A 4j7xJ-5nfhA:
3.2		 4j7xJ-5nfhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 PHE A 762
LEU A 728
VAL A 723
ILE A 724
LEU A 717
 None
 1.43A 4k38B-5nfhA:
undetectable		 4k38B-5nfhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ARG A 451
THR A 398
ILE A 365
THR A 455
 None
 0.94A 4l39B-5nfhA:
undetectable		 4l39B-5nfhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 5 THR A 284
PHE A 243
ASN A 480
TYR A 481
 None
None
None
MET  A 807 ( 4.9A)
 1.38A 4mf6A-5nfhA:
undetectable		 4mf6A-5nfhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 585
HIS A 545
TYR A 593
ILE A 257
 None
 0.83A 4ms4A-5nfhA:
3.2		 4ms4A-5nfhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 9 VAL A 499
LEU A 498
SER A 497
GLY A 484
LEU A 505
 None
 0.96A 4rs0A-5nfhA:
undetectable		 4rs0A-5nfhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 258
HIS A 259
VAL A 473
GLY A 516
ASP A 518
 None
 1.09A 5hg0B-5nfhA:
7.6		 5hg0B-5nfhA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 HIS A 256
GLY A 258
HIS A 259
VAL A 473
ASP A 518
 None
 1.00A 5hg0B-5nfhA:
7.6		 5hg0B-5nfhA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 5 CYH A 470
ILE A 461
LEU A 456
HIS A 289
 None
 1.21A 5hrqC-5nfhA:
undetectable
5hrqD-5nfhA:
undetectable
5hrqL-5nfhA:
undetectable		 5hrqC-5nfhA:
2.99
5hrqD-5nfhA:
4.90
5hrqL-5nfhA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 THR A 332
ASP A 287
ASP A 476
GLY A 290
 None
MET  A 807 (-3.6A)
None
None
 0.82A 5hwaA-5nfhA:
undetectable		 5hwaA-5nfhA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 269
ILE A 661
SER A 246
VAL A 514
HIS A 545
 None
 1.17A 5km9B-5nfhA:
undetectable		 5km9B-5nfhA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ILE A 437
ALA A 439
ALA A 524
ILE A 525
ILE A 542
 None
DMS  A 805 ( 4.2A)
None
None
None
 0.95A 5mvmD-5nfhA:
5.5
5mvmE-5nfhA:
5.5		 5mvmD-5nfhA:
9.30
5mvmE-5nfhA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 ALA A 544
PRO A 429
PHE A 431
GLU A 435
 None
 1.16A 5odqA-5nfhA:
2.8		 5odqA-5nfhA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 TYR A 250
ASP A 287
THR A 332
VAL A 471
 MET  A 807 (-3.2A)
MET  A 807 (-3.6A)
None
None
 1.00A 5ov9A-5nfhA:
3.2		 5ov9A-5nfhA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A 250
ASP A 287
THR A 332
VAL A 471
 MET  A 807 (-3.2A)
MET  A 807 (-3.6A)
None
None
 1.02A 5ov9B-5nfhA:
undetectable		 5ov9B-5nfhA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 611
VAL A 723
ILE A 599
GLY A 604
ALA A 576
 None
 1.11A 6c2mA-5nfhA:
undetectable		 6c2mA-5nfhA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 611
VAL A 723
ILE A 599
GLY A 604
ALA A 576
 None
 1.12A 6c2mB-5nfhA:
undetectable		 6c2mB-5nfhA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 LEU A 532
ALA A 529
LEU A 416
ILE A 542
HIS A 523
 None
None
None
None
MET  A 807 ( 4.7A)
 1.28A 6cbzB-5nfhA:
undetectable		 6cbzB-5nfhA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ARG A 434
ALA A 524
ILE A 515
PRO A 429
ILE A 427
 None
 1.04A 6difA-5nfhA:
undetectable		 6difA-5nfhA:
8.97