SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		5 / 11 ALA B  71
ASP B 102
LEU B 161
GLY B 103
ALA B 168
 None
 1.11A 1b02A-5nfiB:
undetectable		 1b02A-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		4 / 8 ARG B 175
ASN B  47
PHE B  48
ASN B 177
 None
 1.26A 1rs6B-5nfiB:
undetectable		 1rs6B-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		4 / 8 ARG B 175
ASN B  47
PHE B  48
ASN B 177
 None
 1.29A 1rs7B-5nfiB:
undetectable		 1rs7B-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		4 / 8 ARG B 175
ASN B  47
PHE B  48
ASN B 177
 None
 1.28A 1zzqB-5nfiB:
undetectable		 1zzqB-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		5 / 8 HIS B 248
SER B 204
ASN B 250
TYR B 209
ARG B 284
 None
 1.50A 2v57A-5nfiB:
undetectable		 2v57A-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		5 / 8 HIS B 248
SER B 204
ASN B 250
TYR B 209
ARG B 284
 None
 1.49A 2v57C-5nfiB:
undetectable		 2v57C-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		5 / 12 PHE B  48
ALA B 176
THR B 174
VAL B  44
GLY B  43
 None
 1.12A 2ve3B-5nfiB:
undetectable		 2ve3B-5nfiB:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		4 / 7 PHE B 239
LEU B 202
LEU B 268
LEU B 252
 None
 0.88A 3bgdB-5nfiB:
undetectable		 3bgdB-5nfiB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		5 / 12 THR B 240
THR B 241
THR B 182
GLU B 180
LEU B 136
 None
 1.47A 3gwxB-5nfiB:
undetectable		 3gwxB-5nfiB:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		4 / 4 LEU B 273
ILE B 281
GLY B 270
ILE B 312
 None
 0.83A 5dzk3-5nfiB:
undetectable
5dzkm-5nfiB:
undetectable		 5dzk3-5nfiB:
undetectable
5dzkm-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		4 / 5 ILE B 281
GLY B 270
ILE B 312
LEU B 273
 None
 0.83A 5dzki-5nfiB:
undetectable
5dzkj-5nfiB:
undetectable
5dzkx-5nfiB:
undetectable		 5dzki-5nfiB:
undetectable
5dzkj-5nfiB:
undetectable
5dzkx-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		4 / 4 ILE B 281
GLY B 270
ILE B 312
LEU B 273
 None
 0.78A 5dzkl-5nfiB:
undetectable
5dzkz-5nfiB:
undetectable		 5dzkl-5nfiB:
undetectable
5dzkz-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4J_A_DMEA608_1
(ACETYLCHOLINESTERASE)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		5 / 9 TYR B 153
TYR B 181
TRP B 110
HIS B 248
GLY B 247
 None
 1.28A 5e4jA-5nfiB:
undetectable		 5e4jA-5nfiB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2
(Porphyromonas
gingivalis) 		5 / 10 VAL B 187
ALA B 237
LEU B 293
THR B 227
LEU B 252
 None
 0.68A 6f5uA-5nfiB:
undetectable
6f5uB-5nfiB:
undetectable		 6f5uA-5nfiB:
27.84
6f5uB-5nfiB:
18.39