SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
3 / 3 PHE A 245
LEU A 254
SER A 311
None
0.71A 1e7aA-5nfjA:
undetectable
1e7aA-5nfjA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
4 / 7 LEU A 271
LEU A 227
MET A 209
LEU A 248
None
1.10A 1kt3A-5nfjA:
undetectable
1kt3A-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
5 / 11 LEU A 290
ILE A 309
GLY A 310
LEU A 336
LEU A 351
SAM  A 501 (-4.2A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.0A)
0.76A 2qmmA-5nfjA:
7.1
2qmmB-5nfjA:
6.8
2qmmA-5nfjA:
undetectable
2qmmB-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
5 / 9 LEU A 290
ILE A 309
GLY A 310
LEU A 336
LEU A 351
SAM  A 501 (-4.2A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.0A)
0.72A 3ai9X-5nfjA:
7.4
3ai9X-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
4 / 5 PRO A 319
SER A 316
LEU A 323
SER A 322
None
None
None
SAM  A 501 (-2.7A)
1.41A 3iluH-5nfjA:
undetectable
3iluH-5nfjA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
3 / 3 LYS A 284
VAL A 279
HIS A 278
None
1.22A 3tj7A-5nfjA:
undetectable
3tj7A-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
4 / 6 LEU A 360
ILE A 357
LYS A 364
LEU A 205
None
0.95A 4w5nA-5nfjA:
undetectable
4w5nA-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
4 / 7 PHE A 282
SER A 277
THR A 274
PHE A 207
None
0.75A 4wnvD-5nfjA:
undetectable
4wnvD-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
12 / 12 LEU A 290
ALA A 292
ILE A 309
GLY A 310
ASP A 314
THR A 321
SER A 322
LEU A 336
LEU A 338
ASN A 350
LEU A 351
MET A 356
SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.7A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.0A)
SAM  A 501 (-3.5A)
0.17A 5nfjB-5nfjA:
32.3
5nfjB-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
12 / 12 LEU A 290
ALA A 292
ILE A 309
GLY A 310
ASP A 314
THR A 321
SER A 322
LEU A 336
LEU A 338
ASN A 350
LEU A 351
MET A 356
SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.7A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.0A)
SAM  A 501 (-3.5A)
0.19A 5nfjC-5nfjA:
33.2
5nfjC-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
5 / 9 LEU A 290
ILE A 309
GLY A 310
LEU A 336
LEU A 351
SAM  A 501 (-4.2A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.0A)
0.75A 5o96A-5nfjA:
6.5
5o96B-5nfjA:
9.4
5o96A-5nfjA:
undetectable
5o96B-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
5 / 12 LEU A 290
ILE A 309
GLY A 310
LEU A 336
LEU A 351
SAM  A 501 (-4.2A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.0A)
0.61A 5twjA-5nfjA:
5.2
5twjA-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
5 / 10 LEU A 290
ILE A 309
GLY A 310
LEU A 336
LEU A 351
SAM  A 501 (-4.2A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.0A)
0.64A 5twjB-5nfjA:
5.6
5twjB-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo
sapiens)
5 / 12 LEU A 290
ILE A 309
GLY A 310
LEU A 336
LEU A 351
SAM  A 501 (-4.2A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.0A)
0.61A 5twjC-5nfjA:
5.7
5twjC-5nfjA:
undetectable