SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 10 LEU A 168
VAL A 128
LEU A 146
LEU A 142
VAL A  76
 None
 1.19A 1cqpA-5nfnA:
undetectable
1cqpB-5nfnA:
undetectable		 1cqpA-5nfnA:
15.17
1cqpB-5nfnA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 LEU A 168
VAL A 288
VAL A 189
TYR A  71
 None
 0.76A 1epbB-5nfnA:
undetectable		 1epbB-5nfnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 4 THR A  79
LEU A 109
VAL A 112
LEU A 116
 None
 0.85A 1fbmB-5nfnA:
undetectable		 1fbmB-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 7 PHE A 166
VAL A  76
GLY A  77
VAL A  81
 None
 0.81A 1p2yA-5nfnA:
undetectable		 1p2yA-5nfnA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 MET A 101
GLU A 104
THR A 215
VAL A 227
 None
 0.83A 1sn5C-5nfnA:
undetectable		 1sn5C-5nfnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 4 VAL A 235
TYR A 211
VAL A  94
SER A 176
 None
 1.43A 2x45B-5nfnA:
undetectable		 2x45B-5nfnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		7 / 10 TYR A 127
THR A 175
HIS A 178
ASP A 180
LYS A 193
HIS A 277
TRP A 291
 None
AKG  A 502 (-3.3A)
MN  A 501 ( 3.2A)
MN  A 501 ( 2.5A)
AKG  A 502 (-3.3A)
MN  A 501 ( 3.3A)
AKG  A 502 (-4.5A)
 0.74A 3kcxA-5nfnA:
21.7		 3kcxA-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 SER A 254
SER A 252
HIS A 198
 None
 0.85A 3mzeA-5nfnA:
undetectable		 3mzeA-5nfnA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 TYR A 208
PHE A 303
ARG A 203
 None
 1.04A 4g19D-5nfnA:
undetectable		 4g19D-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 HIS A 278
ALA A 258
TYR A 253
ASP A 241
 None
 0.95A 4k0bB-5nfnA:
undetectable		 4k0bB-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 HIS A 278
ALA A 258
TYR A 253
ASP A 241
 None
 0.92A 4l7iB-5nfnA:
undetectable		 4l7iB-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 7 PRO A 199
VAL A  25
ALA A  20
PHE A  16
 None
 1.08A 4lb2A-5nfnA:
undetectable		 4lb2A-5nfnA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 TYR A 253
SER A 252
ILE A 238
LEU A 177
ALA A 256
 None
 1.39A 5zwrB-5nfnA:
undetectable		 5zwrB-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 LEU A 109
LEU A  69
PRO A  70
ILE A 286
VAL A 189
 None
 1.27A 6debB-5nfnA:
undetectable		 6debB-5nfnA:
20.73